Vitamin B2 Riboflavin.pdf

HNUT10010 HNUT10020 Human Nutrition 1: Understanding Nutrients Aifric O’Sullivan BSc, MSc, PhD UCD Institute of Food and Health School of Agriculture and Food Science Vitamin B2 (Riboflavin) Component of two co-enzymes: Flavin mononucelotide Flavin adenine dinucleotide The Nutrition Society Text...

HNUT10010 HNUT10020 Human Nutrition 1: Understanding Nutrients Aifric O’Sullivan BSc, MSc, PhD UCD Institute of Food and Health School of Agriculture and Food Science Vitamin B2 (Riboflavin) Component of two co-enzymes: Flavin mononucelotide Flavin adenine dinucleotide The Nutrition Society Textbook Series, Introduction to Human Nutrition, Second Edition © 2009, 2002 Vitamin B2 Foods PRI 1.3-1.6 mg/MJ • Whole grain, enriched grain foods, and fortified cereals • Milk, cheese and other dairy products • Eggs • Almonds • Salmon, halibut, chicken, beef, liver • Broccoli, asparagus, and spinach Vitamin B2 Metabolic Function • Electron carriers in oxidation and reduction reactions, central to metabolic processes – Mitochondrial electron transport chain – Fatty acid oxidation – Amino acid oxidation – TCA cycle • Glutathione reductase (antioxidant enzyme) Riboflavin (B2) and Niacin (B3) Oxidation/Reduction Glycolysis Βeta-oxidation Pyruvate to Acetyl-CoA TCA cycle Flavin adenine dinucleotide Nicotinamide adenine dinucleotide FAD  FADH2 NAD  NADH + H+ ETC Riboflavin Deficiency Inflammatory lesion (mouth) Lower metabolic rate, related to lipid metabolism Reading • Gibney M, Lanham-New S, Cassidy A, Vorster H, eds. Introduction to Human Nutrition. 2nd ed: Wiley-Blackwell, 2009. Chapter 8 • Gropper SS, Smith JL. Advanced Nutrition and Human Metabolism, International Edition 6th ed: Wadsworth Cenage Learning, 2013. Chapter 9/10 • Whitney E, Rolfes SR. Understanding Nutrition, 13th Edition: Wadsworth, Cengage Learning, 2013. Chapter 10/11