Diploma in Healthcare Drugs Affecting Autonomic Nervous System PDF

Diploma in Healthcare Drugs that act on Autonomic Nervous System Please do not reproduce, redistribute or share without the prior express permission of the author. UNIT 8 DRUGS THAT ACT ON AUTONOMIC NERVOUS SYSTEM Please do not reproduce, redistribute or share without the prior express permission of...

Diploma in Healthcare Drugs that act on Autonomic Nervous System Please do not reproduce, redistribute or share without the prior express permission of the author. UNIT 8 DRUGS THAT ACT ON AUTONOMIC NERVOUS SYSTEM Please do not reproduce, redistribute or share without the prior express permission of the author. Topic/ Chapter Learning Outcome 1. Identify 2 primary division of nervous system. 2. Compare and contrast the action of the sympathetic and parasympathetic nervous system. 3. Define Cholinergic drug and their effect on ANS. 4. Define Cholinergic blocking drug and their effect on ANS. 5. Define Adrenergic drug and their effect on ANS. 6. Define Adrenergic blocking drug and their effect on ANS. Please do not reproduce, redistribute or share without the prior express permission of the author. Nervous System Please do not reproduce, redistribute or share without the prior express permission of the author. The Autonomic Division Parasympathetic Slow down the body activity when the body is not under stress. Helps conserve body energy. Rest and digest Slowing heart rate, digesting food, elimination of body waste. Sympathetic Increase overall body activity during times of stress, excitement or danger. Regulate the expenditure of energy. Fight or flight response. Operative in danger, intense emotion or severe illness. Please do not reproduce, redistribute or share without the prior express permission of the author. Please do not reproduce, redistribute or share without the prior express permission of the author. What information that we can get from Autonomic Pharmacology ? Drug A blocks receptors for neurotransmitter X + Nerves to organ Y release neurotransmitter X, and X increases the activity of organ Y Drug A decreases activity of organ Y Please do not reproduce, redistribute or share without the prior express permission of the author. Drugs Act on Sympathetic Nervous System Adrenergic Drugs Please do not reproduce, redistribute or share without the prior express permission of the author. Adrenergic Agonist Drugs that mimic the activity of sympathetic nervous system. Also known as sympathomimetic drugs. MOA: Stimulates the sympathetic nervous system. Thus will Increase the body activities. Examples: Epinephrine Amphetamine Please do not reproduce, redistribute or share without the prior express permission of the author. Therapeutic Uses Used to treat Hypotension Bronchial asthma Cardiac arrest Nasal congestion Adverse Reactions Hypertension (dangerous level) Tachycardia Headache Insomnia Nervousness Please do not reproduce, redistribute or share without the prior express permission of the author. Adrenergic Blockers Also called sympathomimetic blocking drugs. MOA: Drugs that inhibit the activity of sympathetic nervous system. Thus will Decrease the body activities. Consist of 4 groups: Alpha (α) adrenergic blocking drugs Beta (ß) adrenergic blocking drugs α/ß adrenergic blocking drugs Anti-adrenergic drugs Please do not reproduce, redistribute or share without the prior express permission of the author. Therapeutic Uses Adverse Reactions Used to treat Hypertension Cardiac arrhythmias Migraine Angina pectoris Hypotension Bradycardia Orthostatic pressure Sedation Weakness Please do not reproduce, redistribute or share without the prior express permission of the author. Drugs Act on Parasympathetic Nervous System Cholinergic Drugs Please do not reproduce, redistribute or share without the prior express permission of the author. Cholinergic Agonist Cholinergic Drugs mimics the activity of the parasympathetic nervous system. Also called parasympathomimitic drugs. MOA: Drugs that stimulate the parasympathetic nervous system. Thus will Decrease the body activities. Examples: Muscarinic agonist Cholinesterase inhibitors Please do not reproduce, redistribute or share without the prior express permission of the author. Cholinergic Agonist (DD) ACh: Acetylcholine AChE: Acetylcholine Esterase DD: Cholinergic agonist Please do not reproduce, redistribute or share without the prior express permission of the author. Therapeutic Uses Used to treat Glaucoma (high pressure in eyes) Myasthenia Gravis (Skeletal muscle cramp) Urinary retension (impaired urination) Adverse Reactions Nausea & diarrhea Cardiac arrhythmias Muscle weakness. Temporary reduction of visual acuity (sharpness) Please do not reproduce, redistribute or share without the prior express permission of the author. Cholinergic Blockers Also called parasympathomimetic blocking drugs. MOA: Drug that inhibit the activity of the parasympathetic nerve system. Thus will Increase the body activities. Examples: Muscarinic receptor antagonist Nicotinic receptor antagonist Please do not reproduce, redistribute or share without the prior express permission of the author. Cholinergic Blockers (D) ACh: Acetylcholine D: Cholinergic blockers Please do not reproduce, redistribute or share without the prior express permission of the author. Therapeutic Uses Adverse Reactions Used to treat Parkinsonism Peptic ulcer Vagal-induced bradycardia Dry mouth & throat Blurred vision Photophobia Constipation Drowsiness Please do not reproduce, redistribute or share without the prior express permission of the author. Reference Holland, LM and Adams MP. 2007. Core Concepts in Pharmacology. 2nd edition.Pearson. Hitner H and Nagle B. 2002. Basic Pharmacology. 4th edition. McGraw-Hill. Please do not reproduce, redistribute or share without the prior express permission of the author. Next Topic Drugs that affect the Endocrine System Please do not reproduce, redistribute or share without the prior express permission of the author. Thank you Address Lot 33-40, Blok C, Plaza Juta, KM 7.2 Off Jalan Tuaran, 88400 Likas, Kota Kinabalu, Sabah, Malaysia Telephone +6088 431 025/35 Website kk.cyberjaya.edu.my Email [email protected] Please do not reproduce, redistribute or share without the prior express permission of the author.