Unit 4 Pharmaceutics (Imperfect Pharmacy) PDF

PHARMACEUTICS UNIT4 NOTES SUPPOSITORIES TYPES OF SUPPOSITORY -" SUPPOSITORY BASES METHOD OF PREPARATION EVALUATION f PHARMACEUTICAL INCOMPATIBILITY IMPERFECT PHYSICAL INC...

PHARMACEUTICS UNIT4 NOTES SUPPOSITORIES TYPES OF SUPPOSITORY -" SUPPOSITORY BASES METHOD OF PREPARATION EVALUATION f PHARMACEUTICAL INCOMPATIBILITY IMPERFECT PHYSICAL INCOMPATIBILITY PHARMACY CHEMICAL INCOMPATIBILITY THERAPEUTIC INCOMPATIBILITY CONNECT WITH US ON : [c;)] @IMPERFECTPHARMACV 0 IMPERFECT PHARMACY  SupPos1ToR1es S_oppasi~omes ore semi so\id, d06a3e forms of vano~~ shapes ~.stus Meant +01> inse6"-h'on th½o bod~ cau,hes like. rechlm, VQ,9ina nose , eao e\-c except mouth. Supposfto-m es comes und('6" E£mi ~ solid prsepo.rah'ons be~ it r's ~epClffd bV melHng ·all -the i'ngredtenl-s. A\\ t~pes of sup?Ositmsies are mell oJ nomvtol t:xxJy -kmperahns-e. Types of Suppos\ tcmies There are moi'n'v 5 hf~ ·Of 6uppasitom'es : © Redal Suppositcrn-ies ® Vogtna.\ SupPosO-oiies @ U1ethro.l Supposiromes ® Nosol Suppcsitmst'es ® ~~ Cone ( Redal SupfX)sHmsies ( fdo.\ suppcs1'tomes bu+ nof StJitabt t f~ pessanes , nasn\ and ureth~ suprosirOcS1es. Emu\slhed -\-heotnromQ Oi\ F-rou\sif,ed theo~orna oil are used as o base when \ar3e quonHhf of aqueous fll\vHon nos to be USed. The~ are \ess sh·ckV t'n noJ-ure COmr1feq -\o theob'lmma oil. ]- rn01h\~ cons;s~ of : - 5 1 8\~ cery I rnonosteara\-e - to 1. \one~~e wax - 091TORtES' I Tue fonowin~ lest are rFoismed fao evalualfon of supp;sirom'e.s : CD Test of appearance ® Tes~ of Ph'ftco.l Slrenfath @ Tes~ of disso\u ~'o n rote ® Test of melHng ron9e ® Tes~ of softening @ Test ~ unif'o"lllllity of drug Cbnlen~ Test of Appearance A\I -ttle supposHo~ies snout~ be unifomneQ t'n size and 6hape. Th~ must ha\Je 900d appearance. Tod,·v,·duol f>uppositm1es should be examined fb~ cracks and pits. Accm-din8 to 8-P· when supp:,st'tomes cu~ lon3itud1'na.ny , -I-hen H-s ex~emal and inteimat surfa~s should be unifbmn t'n a~ce. T~~ of Ph~sicaj Stre'!,qth The fest t's a:miied out to check -the bmHf.eness and ~\ashdtlf of supposito,nes. In -thfs +~ SJpfs. T€5~ ~ So~ening r~ \S ,also lq)own as Iiquefachon test-. The -\-es\ is perfotm1ed to cherk \he roAness of SUflX)S1'to,r,es. In -\his we rnrosure the ~'me reqo,red fens- 6\JffOSHcrm'es ~ comptaely gets -\,qui~. Test ~ Unifonnihf of Drug Confen~ Tue \-esl 1's ~ e d lo ·chef< -\he unifO'ITTYlltl( of df\J~ prewi!- in sup~ t¼nm, ooses 4 A\I \he.suppooitom'es snould contoi'n ~e some labelled o{ dru;!.  I DISPLACEMENT VAWE I Tue quanh"( of -!he dru3 -that d1Sp1aces one pru~ or supposilory base fs known as displacement vaJue. When Q suwosi~Dm/ mould ,·s ~lied bl( suppasito~y I -\hen VOIUM1e 01f ,·n~ensi~ of -the O(hon Foduced is diWe1fen\ fu:>m -thoJ 1'n~end~ bV ~saibe?r Causes of Thero~uh'c Tncompo.tabi\ih'es TI- fn