Paraneoplastic Syndrome PDF
Document Details
Uploaded by Deleted User
Fatima Alhaddad
Tags
Summary
This presentation details paraneoplastic syndrome, encompassing its definition, clinical presentation, associated tumors, and diagnostic methods. The presentation also touches upon the relationship between cancer (Hodgkin's lymphoma) and paraneoplastic syndromes, while concluding with references and a quiz.
Full Transcript
Paraneoplastic Syndrome Fatima Alhaddad Definition Complex of Symptoms that cannot be explained by spread or hormones production 10% to 15% of cancer patients Clinical presentatio n Cachexia Weakness Anorexia Anemia Tumors Most common: Hypercalcemia: ○ Lung, brea...
Paraneoplastic Syndrome Fatima Alhaddad Definition Complex of Symptoms that cannot be explained by spread or hormones production 10% to 15% of cancer patients Clinical presentatio n Cachexia Weakness Anorexia Anemia Tumors Most common: Hypercalcemia: ○ Lung, breast, renal and hematologic ○ PTHrP Cushing syndrome ○ Lung, pancreatic and neural ○ ACTH or ACTH-like polypeptides Nonbacterial thrombotic endocarditis ○ Advanced ○ Hypercoagulability Investigations and 1. diagnosis Morphologic Methods: a. Biopsy b. Fine needle aspiration c. Cytology smears 2. Molecular Diagnosis a. PCR or FISH b. Diagnosis and Prognosis 3. Tumor Markers a. Eg.PSA b. Screening and Monitoring 4. Molecular Profiling of Tumors (The Future of Cancer Diagnostics) a. RNA expression profiling b. DNA sequencing c. DNA copy number arrays Relation to our triggers History of cancer (Hodgkin’s Lymphoma) = Paraneoplastic cerebellar degeneration syndrome Quiz References: Robbins Basic Pathology 10th edition Thank you for listening Any Questions?
