N5463 Oncology Paraneoplastic Syndromes Chart PDF

N5463 Oncology Paraneoplastic Syndromes Type Endocrine Syndrome SIADH* Hypercalcemia* Cushing Syndrome* Hypoglycemia* Hematologic Eosinophilia* Granulocytosis* Clinical Manifestations Associated Cancers Gait instabilities, falls, headaches, nausea, fatigue, mental status changes, muscle cramps Low s...

N5463 Oncology Paraneoplastic Syndromes Type Endocrine Syndrome SIADH* Hypercalcemia* Cushing Syndrome* Hypoglycemia* Hematologic Eosinophilia* Granulocytosis* Clinical Manifestations Associated Cancers Gait instabilities, falls, headaches, nausea, fatigue, mental status changes, muscle cramps Low serum sodium Increased urine osmolality Altered mental status, weakness, hypertonic, N/V, hypertension, bradycardia, renal failure Low calcium levels, low or normal PTH Edema, hypertension, muscle weakness, weight gain, central obesity, hypokalemia, elevated baseline cortisol > 39.0 mcg/dL, elevated midnight ACTH not suppressed by dexamethasone Sweating, anxiety, tremors, palpitations, hunger, weakness, seizures, confusion, coma. Low glucose level, low C-peptide level Lung, bladder, ureteral, endometrial, prostate, GI, Brain, breast, adrenal, Ewing Sarcoma, oropharyngeal, thyoma Dyspnea, wheezing Elevated eosinophil levels Elevated IL-2, IL-3, IL-5 Elevated neutrophil count, otherwise no symptoms Hodgkin Lymphoma, non-Hodgkin lymphoma, leukemia, lung, thyroid, GI, renal, breast and gynecologic GI, lung, breast, gynecologic, GU, brain, Hodgkin lymphoma, sarcoma Breast, multiple myeloma, renal cell carcinoma, lung squamous cell cancers, ovarian, endometrial, lymphoma Lung cancers, thyoma, thyroid cancer, GI, pancreatic, adrenal ovarian Lung, sarcoma, GI Dermatologic Pure Red Cell Aplasia* Dyspnea, pallor, fatigue, syncope Thrombocytosis* Elevated platelet count Acanthosis Nigricans* Velvety, hyperpigmented skin, usual in the skin folds Rugose changes of the palm and dorsal surface of large joints Heliotrope rash (violaceous, edematous rash of the upper eyelids), erythematous rash which may be photosensitive on face, neck, chest, back. Dysphagia, dyspnea, muscle weakness, muscle pain. Erythematous, exfoliating, diffuse rash. May be pruritic. New bone formation on phalangeal shafts. Synovial effusions. Pain, swelling of affected bones. Ulceration & cyanosis and pain over the affected areas (digits mainly). Palpable purpura, renal impairment, peripheral purpura. Severe cutaneous blisters and erosions. Mucosal erosions, stomatitis Limb girdle pain and stiffness Elevated SED rate and CRP Dermatomyositis (DM)* Erythroderma* Hypertrophic osteoarthropathy Leukocytoclastic vasculitis Paraneoplastic pemphigus Polymyalgia rheumatica* (PMR) Leukemia, lymphoma, myelodysplastic syndrome, Thymoma GI, lung, breast, gynecologic, lymphoma, renal cell, prostate, glioblastoma, head and neck GI adenocarcinoma, most common gastric. Gynecologic Ovarian, breast, prostate, lung, colorectal, non-Hodgkin lymphoma, nasopharyngeal Leukemia, Lymphoma, GI, myeloproliferative disorders Intrathoracic tumor, metastases to lung, metastases to bone, nasopharyngeal carcinoma, rhabdomyosarcoma Leukemia, lymphoma, myelodysplastic syndromes, colon, lung, urologic, multiple myeloma, rhabdomyosarcoma Non-Hodgkin Lymphoma, leukemia, thymoma, castleman disease, follicular dendritic cell sarcoma Leukemia, lymphoma, myelodysplastic syndromes, colon, lung, renal, prosate, breast Sweet Syndrome Neurologic Limbic encephalitis Lambert-Eaton Myasthenic Syndrome (LEMS) Myasthenia Gravis (MG) Acute onset of tender, erythematous nodules, plaques, or pustules on extremities, face, or upper trunkc Neutrophilia with fever Malaise Mood changes, memory loss, seizures Lower extremity proximal muscle weakness, fatigue, weakness of the diaphragm Fatigable weakness of the skeletal muscles *These are the syndrome you should know. The others are for FYI purposes. Leukemia, Non-Hodgkin Lymphoma, myelodysplastic syndrome, GU, breast, GI, multiple myeloma, gynecologic, testicular, melanoma Lung, testicular, breast, thymoma, Hodgkin lymphoma Lung, prostate, cervical, lymphomas, adenocarcinomas Thymoma