Tech Sheet_Glutathione_RB00-v11web.pdf

LIPOSOMAL GLUTATHIONE THIS INFORMATION IS PROVIDED AS A MEDICAL AND SCIENTIFIC EDUCATIONAL RESOURCE FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS (“PRACTITIONERS”). THIS INFORMATION IS INTENDED FOR PRACTITIONERS TO USE AS A BASIS FOR DETERMINING WHETHER TO RECOMMEND THESE PR...

LIPOSOMAL GLUTATHIONE THIS INFORMATION IS PROVIDED AS A MEDICAL AND SCIENTIFIC EDUCATIONAL RESOURCE FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS (“PRACTITIONERS”). THIS INFORMATION IS INTENDED FOR PRACTITIONERS TO USE AS A BASIS FOR DETERMINING WHETHER TO RECOMMEND THESE PRODCUTS TO THEIR PATIENTS. ALL RECOMMENDATIONS REGARDING PROTOCOLS, DOSING, PRESCRIBING AND/ OR USAGE INSTRUCTIONS SHOULD BE TAILORED TO INDIVIDUAL NEEDS OF THE PATIENT CONSIDERING THEIR MEDICAL HISTORY AND CONCOMITANT THERAPIES. THE DIETARY SUPPLEMENTS OFFERED BY QUICKSILVER SCIENTIFIC ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT, DIAGNOSE, OR MITIGATE ANY DISEASE OR OTHER MEDICAL CONDITION. Liposomal Glutathione is reduced L-Glutathione (GSH), a tripeptide consisting of glutamic acid, cysteine, and glycine. Known as our body’s master antioxidant, Liposomal Glutathione is an ally in detoxification, healthy aging, and immunity. EDUCATION SUPPORTS ALL THREE PHASES OF DETOXIFICATION Glutathione is the body’s master detoxifier and most potent endogenous antioxidant.1 Glutathione offers comprehensive antioxidant protection, binding to a wide array of damaging molecules, including reactive oxygen species (ROS), lipid peroxides, xenobiotics, pesticides, mycotoxins, oxidized vitamin E, oxidized vitamin C, methylmercury, medications, heavy metals, and other harmful substances. Glutathione serves as an essential cofactor for critical and powerful antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR) and glutathione-s-transferase (GST).2 Glutathione also helps regenerate the antioxidants vitamin C and vitamin E.3 Glutathione offers potent protection inside the mitochondria, our cells’ energy powerhouses; is critical to our immune system function, helps dampen inflammation; is a key player in autoimmunity; and may confer protection against multiple disease states.4,5,6,7,8,9 Glutathione is present in every single cell of our bodies—at surprisingly high levels equal to that of glucose, potassium or cholesterol.10 Concentrations are five to ten times higher in hepatocytes than other cells as the liver is constantly processing and removing toxins.11 Strengthening the glutathione system supports all three phases of detoxification, but in particular phases II and III.12 Phase I—Oxidation: The liver converts a lipid-soluble toxin into a less harmful compound, preparing it for phase II detoxification. This occurs through oxidation, reduction and hydrolysis of substances via cytochrome P450 enzymes. Phase II—Conjugation: Glutathione binds to the toxin, rendering it water-soluble. This occurs through sulfation, glucuronidation, and glutathione conjugation of toxins. Phase III—Elimination: Cellular transport and elimination of the conjugated toxin through bile or urine. Optimal phase II and III detoxification requires the activation of the cellular master switch Nrf2.13 Nrf2 regulates over 500 genes involved in detoxification. POTENT ANTI-INFLAMMATORY ACTION AND AUTOIMMUNE SUPPORT Glutathione is integral to the proper function of our immune system. In autoimmune diseases, activated neutrophils and chronic inflammation lead to continual production of ROS and oxidative stress.6 Altered intracellular levels of reduced glutathione (GSH) have been seen in infections and autoimmune disease, along with immune activation and inflammation.14 The two arms of the immune system, TH1 and TH2, are regulated by intracellular glutathione levels, and even a modest increase in intracellular glutathione (GSH) and glutathione disulfide (GSSG) levels potentiates the immune action of lymphocytes.15,16 Reduced levels of GSH have been linked with lupus, rheumatoid arthritis, autoimmune thyroiditis, cataracts, and aging.17,18,19,20,21 CONJUGATES AND ELIMINATES MYCOTOXINS, METHYLMERCURY AND OTHER NEUROTOXINS Glutathione plays an essential role in defending us from mercury toxicity. Mercury is a potent biological toxin that is present in auto pollution, fish, dental amalgam, vaccines, and contaminated air and water. Glutathione targets and binds methylmercury and prevents it from penetrating the cell, thereby reducing inflammation and protecting against oxidative damage.22 Glutathione is also critical in conjugating and eliminating other heavy metals, such as arsenic.23 PROTECTS THE HEART AND BRAIN Glutathione is the most abundant antioxidant in the heart. Lowered levels play an important role in the development of cardiovascular diseases, and have been found in patients with coronary artery disease.24 Depressed glutathione synthesis can lead to atherogenesis (fatty plaques) and is also associated with hypertension.25 In contrast, an increased level of intracellular glutathione is correlated with lower blood pressure and a decreased incidence of diabetes.26 In addition, glutathione is a key antioxidant for the mitochondria, which are more abundant in heart muscle than any other tissue in the body.4 Just as glutathione protects the heart, it can be neuroprotective and help support brain function.27 Neurodegenerative diseases are linked to increased mitochondrial oxidative stress, and lowered levels of mitochondrial glutathione.28 The increased oxidative stress noted in Alzheimer’s disease and mild cognitive impairment has been attributed to lowered levels of glutathione in the brain.9 Quicksilver Delivery Systems® improve upon liposomal and emulsification technology with smaller, more stable particles made from the highest-grade ingredients available. In addition to exceptional absorption rates, these tiny liposomal and nanoemulsified particles increase diffusion across mucus membranes, enhance lymphatic circulation of nutrients and support cellular delivery. ® References available at quicksilverscientific.com/glutathionereferences TS210013 Rev. 01