Dr. Shade's Bitters No.9 Tech Sheet PDF

DR. SHADE’S BITTERS NO.9 ® THIS INFORMATION IS PROVIDED AS A MEDICAL AND SCIENTIFIC EDUCATIONAL RESOURCE FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS (“PRACTITION...

DR. SHADE’S BITTERS NO.9 ® THIS INFORMATION IS PROVIDED AS A MEDICAL AND SCIENTIFIC EDUCATIONAL RESOURCE FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS (“PRACTITIONERS”). THIS INFORMATION IS INTENDED FOR PRACTITIONERS TO USE AS A BASIS FOR DETERMINING WHETHER TO RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. ALL RECOMMENDATIONS REGARDING PROTOCOLS, DOSING, PRESCRIBING AND/OR USAGE INSTRUCTIONS SHOULD BE TAILORED TO THE INDIVIDUAL NEEDS OF THE PATIENT CONSIDERING THEIR MEDICAL HISTORY AND CONCOMITANT THERAPIES. THIS INFORMATION IS NOT INTENDED FOR USE BY CONSUMERS. Dr. Shade’s Bitters® No. 9 is a blend of nine bitter herbs and essential oils that helps orchestrate optimal digestion and detoxification via the liver, gallbladder, and kidneys. Our formula features a proprietary blend of classic bitter botanicals, including dandelion, milk thistle, gentian, burdock root, and Solidago (goldenrod). The suite of bitter botanicals is rounded out by essential oils of sweet orange, myrrh, juniper, and clove. EDUCATION BILE FLOW: THE MISSING LINK IN DETOXIFICATION Detoxification is a complex, multi-step process that moves toxins out of cells, into the liver and gallbladder and out of the body via the digestive tract and kidneys. For decades, detoxification protocols have primarily addressed the intestine and kidneys, overlooking the critical role of the gallbladder and bile flow in facilitating detoxification. Bile is a fluid produced in the liver and secreted by the gallbladder that both aids in the digestion of dietary fats and transports toxins into the intestine so they can be excreted from the body. Bile is comprised of bile acids, salts, phospholipids, cholesterol, and water. Fascinating research indicates that the cellular transporters that move bile acids and salts in and out of the intestine also transport toxins.1,2 Therefore, sluggish bile flow, also known as cholestasis, slows toxin efflux and impedes successful detoxification. Various factors contribute to cholestasis, including gallstones, biliary disease, chronic liver disease, certain medications, excess estrogen, and endotoxin, also known as lipopolysaccharide or LPS.3,4 In addition to having a direct negative impact on detoxification, poor bile flow contributes to gastrointestinal dysbiosis and conditions such as small intestinal bacterial overgrowth (SIBO).5 Insufficient bile flow may also promote the formation of intestinal biofilm, a consortium of microorganisms embedded in a sticky matrix that allows pathogens to evade antibiotics and the immune system, enhancing their infectivity.6 Dysbiosis, SIBO, and intestinal biofilm exert negative feedback on detoxification by increasing LPS and inflammatory cytokines, creating a vicious cycle of bile stagnation and GI distress.7 BITTER BOTANICALS SUPPORT GENTLE DETOXIFICATION An array of bitter botanicals have been found to activate the cellular transporters necessary to move bile and toxins from the liver and gallbladder into the intestine. Dandelion, milk thistle, gentian, burdock root, Solidago, and myrrh essential oil have long been used in traditional herbalism to support the detoxification and cleansing functions of the body. Emerging scientific research corroborates the effects of these botanicals on an assortment of detoxification enzymes and systems. Juniper, clove, and sweet orange essential oils offer antimicrobial and anti-inflammatory effects that complement the effects of bitter botanicals on digestion and detoxification.29,30,31 Dandelion supports diuresis, enhancing urinary elimination of toxins. It also protects the liver, enhances bile flow, inhibits LPS-induced inflammation, and upregulates antioxidant pathways such as Nrf2.8,9,10 Milk thistle is a time-honored botanical in traditional Western herbalism. Silymarin, the primary bioactive constituent of milk thistle, increases bile flow.11 It supports phase II detoxification by activating the Nrf2 pathway, which ultimately enhances glutathione production.12 A true multi-purpose detoxification promoter, silymarin and its sister compound, silychristin, also stabilize MRP2 and BSEP transporters, bile acid transporters involved in phase III detox that usher bile and xenobiotics, such as mercury and mycotoxins, out of the body.13,14 Last but not least, milk thistle alleviates hepatic inflammation induced by exogenous and endogenous toxins.15,16 Gentian, a full-bodied bitter botanical, also promotes healthy bile flow. Two of its bioactive compounds, gentiopicroside and gentiolactone, have been found to protect the liver from cholestasis-induced liver damage, inhibit LPS-induced toxicity, and upregulate antioxidant enzyme activity.17,18,19 Solidago, a flowering plant with tiny, bright yellow blossoms, has a long history of use in traditional herbalism for supporting the urinary tract. It promotes diuresis and toxin elimination while simultaneously increasing the activity of glutathione S-transferase, a critical enzyme in phase II detoxification.20,21 The bioactive polyphenols in Solidago also have antimicrobial activities against Staphylococcus aureus and Candida albicans, common infectious organisms in humans.22 Burdock root is a hearty root vegetable that has been used for thousands of years in Traditional Chinese Medicine and Western folk herbalism. It is revered for its cooling, decongesting effects on the liver and digestive system, mediated by its bitter principles. Modern-day science indicates that burdock root has potent anti-inflammatory properties, while also protecting against xenobiotic-induced liver injury.23,24,25 The essential oil of myrrh, a resinous substance derived from the Commiphora mukul tree native to India, supports healthy bile flow by increasing the expression of the human bile salt export pump and promotes a healthy microbial balance.26,27 Juniper essential oil has anti-inflammatory and antimicrobial properties28,29 Clove essential oil contains eugenol, a potent antimicrobial agent with a pleasant, spicy scent. Sweet orange essential oil offers antioxidant and antimicrobial properties.30,31,32 Quicksilver Delivery Systems® improve upon liposomal and emulsification technology with smaller, more stable particles made from the highest-grade ingredients available. In addition to exceptional absorption rates, these tiny liposomal and nanoemulsified particles increase diffusion across mucous membranes, enhance lymphatic circulation of nutrients and support cellular delivery.* TS220002 References available at quicksilverscientific.com/bittersno9references Rev.01 WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. DO NOT USE IF PREGNANT, BREAST-FEEDING, OR PLANNING TO BECOME PREGNANT. KEEP OUT OF REACH OF CHILDREN. Consult a healthcare professional before use if you have any medical condition or are taking any other supplements or medications. Do not exceed recommended dosage. See www.quicksilverscientific.com for additional safety information. This information is for the use of licensed healthcare practitioners only and is intended to use as a basis for ® determining whether or not to recommend these products to their patients. This medical and scientific information is not for use by consumers.