CDC STI Treatment Guidelines 2021 PDF

Summary of CDC STI Treatment Guidelines, 2021 This wall chart reflects recommended regimens found in CDC’s Sexually Transmitted Infections Treatment Guidelines, 2021. This su...

Summary of CDC STI Treatment Guidelines, 2021 This wall chart reflects recommended regimens found in CDC’s Sexually Transmitted Infections Treatment Guidelines, 2021. This summary is intended as a source of clinical guidance. When more than one therapeutic regimen is recommended, the sequence is in alphabetical order unless the choices for therapy are prioritized based on efficacy, cost, or convenience. The recommended regimens should be used primarily; alternative regimens can be considered in instances of substantial drug allergy or other contraindications. An important component of STI treatment is partner management. Providers can arrange for the evaluation and treatment of sex partners either directly or with assistance from state and local health departments. Complete guidelines can be found online at www.cdc.gov/std/treatment. DISEASE RECOMMENDED REGIMEN ALTERNATIVE REGIMEN DISEASE RECOMMENDED REGIMEN ALTERNATIVE REGIMEN Bacterial Vaginosis metronidazole 500 mg orally 2x/day for 7 days clindamycin 300 mg orally 2x/day for 7 days Lymphogranuloma Venereum doxycycline 100 mg orally 2x/day for 21 days azithromycin 1 gm orally 1x/week for 3 weeks 20 OR metronidazole gel 0.75%, one 5 gm applicator OR clindamycin ovules 100 mg intravaginally at bedtime OR erythromycin base 500 mg orally 4x/day for intravaginally, 1x/day for 5 days for 3 days1 21 days OR clindamycin cream 2%, one 5 gm applicator OR secnidazole 2 gm orally in a single dose2 intravaginally, at bedtime for 7 days Nongonococcal Urethritis (NGU) doxycycline 100 mg orally 2x/day for 7 days azithromycin 1 gm orally in a single dose OR tinidazole 2 gm orally 1x/day for 2 days OR azithromycin 500 mg orally in a single dose, THEN OR tinidazole 1 gm orally 1x/day for 5 days 250 mg 1x/day for 4 days Cervicitis3 doxycycline 100 mg orally 2x/day for 7 days azithromycin 1 gm orally in a single dose Persistent or Recurrent NGU: test for Mycoplasma genitalium: Chlamydial Infections If M. genitalium resistance testing is doxycycline 100 mg orally 2x/day for 7 days, For settings without resistance testing and when unavailable but M. genitalium is detected FOLLOWED BY moxifloxacin 400 mg 1x/day for moxifloxacin cannot be used: Adults and adolescents doxycycline 100 mg orally 2x/day for 7 days azithromycin 1 gm orally in a single dose by an FDA-cleared NAAT 7 days doxycycline 100 mg orally 2x/day for 7 days, OR levofloxacin 500 mg orally 1x/day for 7 days FOLLOWED BY azithromycin 1 gm orally on first day, FOLLOWED BY azithromycin 500 mg orally 1x/day Pregnancy azithromycin 1 gm orally in a single dose amoxicillin 500 mg orally 3x/day for 7 days for 3 days and a test-of-cure 21 days after completion of therapy Infant and children