Psychosis Pathophysiology PDF

DA WHAT IS THE PATHOPHYSIOLOGY OF PSYCHOSIS? Multifactorial and not clearly defined • There are 4 key dopaminergic tracts in the body however tracts 2 and 3 are implicated in schizophrenia 1. Nigrostriatal: dopamine receptor blockade → EPS 2. Mesolimbic: ↑dopamine → positive symptoms • Mesocor...

DA WHAT IS THE PATHOPHYSIOLOGY OF PSYCHOSIS? Multifactorial and not clearly defined • There are 4 key dopaminergic tracts in the body however tracts 2 and 3 are implicated in schizophrenia 1. Nigrostriatal: dopamine receptor blockade → EPS 2. Mesolimbic: ↑dopamine → positive symptoms • Mesocortical: ↓dopamine → negative symptoms Negative symptoms: decrease/absence of normal function associated with dopamine receptor hypofunction (mesocorticol) dddDA & mesocortical path i( ID Tuberoinfundibular: dopamine blockade → increased prolactin :1 • 4. at mesclimbic path Positive symptoms: excess/distortion of normal function associated with dopamine receptor hyperactivity (mesolimbic) exaggerated /hallncination) ↑DA = PleasureT Za hr av 3. 01 41 0) • Copyright © 2023 PharmAchieve Corporation Ltd. Private and Confidential. except clozapine (resistant) and generation preferred 1st line , la 3 All Antipsychotics are Le y WHAT ARE THE TYPES OF SYMPTOMS AND WHAT IS THE DIFFERENCE BETWEEN POSITIVE AND NEGATIVE SYMPTOMS? to Positive symptoms: distortion of normal mental functioning and reality ns ed • Hallucinations, delusions, disorganized thinking, disorganized or catatonic behaviour ce Negative symptoms: decreased or absence in normal mental functioning Li • Affective flattening (lack of emotion), alogia (inability to carry a logical conversation, anhedonia (inability to feel pleasure), avolition (lack of motivation), social withdrawal Impaired cognitive functioning • Reduced concentration, impaired memory, impaired functioning Copyright © 2023 PharmAchieve Corporation Ltd. Private and Confidential. 4 Copyright © 2023 PharmAchieve Corporation Ltd. Private and Confidential. 2