problem 3 Lactic Acidosis Sameh 2024-2025.pdf

Mechanisms of Lactic Acidosis bloodstream lactate in · high - lactate produced by glycolysis...

Mechanisms of Lactic Acidosis bloodstream lactate in · high - lactate produced by glycolysis becomes lactate ↳ pyruvate - lactate produced by our body when becomes pathologic between theres imbalance excretion production and of lactate -buildup Dr. Sameh Sarray, PhD Department of Medical Biochemistry  acid. lactate is a hydrocarboxylic · · made of 2 stereolsomers 1. 2. L-lactate D-lactate (Predominant) How lactate is produced? The structure : ❑ Hydrocarboxylic acid: 2 stereoisomers: L-lactate (predominant) and D-lactate ❑ The main sources of intracellular L-lactate are glucose and alanine (by transamination reaction catalyzed by ALT). The pyruvate produced will be reduced into lactate: ❑ in anaerobic conditions catalyzed by LDH when pyruvate oxidation in citric cycle is overwhelmed Sources : glucose Balanine lactate will become - pyruvate inanaerobcons en in citric  What happens to the lactate? lactate metabolizes by I liver. 2 Kidney liver : converted toglucose by giuceogenesis by cori cycle uses 6 ATP Kidney : gets rid of It in 3 ways I giuceogenesis > urine. excretion - 2 · 3 Oxidation The lactate is metabolized predominantly in the liver and kidney: Liver: Lactate is converted to glucose by gluconeogenesis through Cori cycle. It uses 6 ATP molecules Kidneys: contribute to lactate removal approximately 10 to 20% of the total lactate metabolized. The kidneys dispose of lactate in three ways: excretion, gluconeogenesis, and oxidation Other tissues can use lactate as a substrate and oxidise it to CO2 and water; It is ONLY the liver and kidney have the enzymes that convert lactate to glucose - other tissues can convert lactate to water and CO2 and can convert lactate Kidney to glucose - only liver ↳ have the enzymes for. they it  Lactic Acidosis 4