Practice Quiz 6 PDF

Practice quiz 6 1. ‘One gene one protein’ hypothesis does not hold true because A. gene expression can be regulated by multiple transcription factor B. pre-mRNA can be spliced alternatively C. protein can be degraded at different rate D. mRNA stability are different for different transcripts E. None...

Practice quiz 6 1. ‘One gene one protein’ hypothesis does not hold true because A. gene expression can be regulated by multiple transcription factor B. pre-mRNA can be spliced alternatively C. protein can be degraded at different rate D. mRNA stability are different for different transcripts E. None of the above. 2. IgG is membrane bound in non-activated B-cells. However, upon activation, B-cells secrete soluble IgG. The membrane bound and secretory IgG are A. produced from the same gene B. synthesized from different start sites C. produced from transcripts that are polyadenylated at different sites D. A and C are correct E. A and B are correct 3. C to U conversion in Apolipoprotein B transcript generates two isoforms of Apo B. A longer form (ApoB-100) is expressed in liver and a shorter isoform (ApoB-48) is expressed in intestine. Which of the following is critical for this conversion? A. APOBEC B. ADAR C. HDAC D. A and B only E. A and C only 4. Regulation of translation initiation can be caused by a hairpin structure at the A. gene promoter site B. transcription termination site C. 5’ or 3’ untranslated regions of the transcript D. ribosomal RNA E. tRNA gene 5. Under starvation, cells halt their protein synthesis globally by A. degradation of ribosomes B. degradation of all mRNAs C. phosphorylation of RNA polymerase D. Phosphorylation of the translation initiation factor 2 E. None of the above 6. The 5’ cap and cap-binding protein is not needed for viral protein synthesis because A. it occurs in the nucleus B. ribosomes are different C. codon usage are different D. it uses long repeat region E. it starts from internal ribosome entry site 7. Poly-A binding proteins are critical for transcript stability, because A. it protects the length of the poly-A tail. B. it adds As to broken tail. C. it recruits deadenylase enzyme. D. it inhibits translation initiation. E. it helps to keep the transcript linearized. 8. Eukaryotic cells produce many non-coding RNAs. These include A. snRNA B. miRNA or siRNA C. piRNA D. lncRNA E. all of the above 9. Expression of a single gene can be regulated by multiple miRNAs and one miRNA can target multiple transcripts A. True B. Falls 10. Many plants use small interfering RNAs to protect themselves from viral attack. Which enzyme is critical for this process? A. RNA polymerase B. RNA helicase C. RNA-dependent RNA polymerase D. Poly-A polymerase E. All of the above 11. miRNAs can be regulated in cells by A. lncRNA sponging B. snoRNAs C. snRNAs D. crRNAs E. siRNAs 12. Some bacteria develops immunity to future viral attack by A. producing crRNAs from CRISPR cluster B. degrading viral RNA by endonuclease C. toxin secretion D. all of the above E. none of the above