Practice Quiz-5 PDF

Practice Quiz-5 1. An enhancer element shows all of the following properties EXCEPT A. promote the assembly of RNA polymerase and general transcription factors B. is functional when located upstream or downstream of the transcription initiation site C. is functional when located in an intron D. act...

Practice Quiz-5 1. An enhancer element shows all of the following properties EXCEPT A. promote the assembly of RNA polymerase and general transcription factors B. is functional when located upstream or downstream of the transcription initiation site C. is functional when located in an intron D. acts as the binding site for a gene regulatory protein E. acts as a binding site for DNA polymerase 2. Gene regulatory proteins possess A. a domain necessary for membrane integration B. protease cleavage site C. a DNA binding domain and an activation domain D. characteristic enzymatic properties E. none of the above 3. X-chromosome inactivation is mediated by A. Spontaneous genetic mutation B. Random recombination C. Global translational inhibition during puberty D. Xist RNA-mediated heterochromatin formation E. Defective replication 4. The leucine zipper motif of the proteins mediates A. interaction between two β-sheet structures B. interaction between protein and RNA C. assembly of multisubunit protein complex D. interaction between different genes E. both DNA binding and protein dimerization 5. Gene regulatory proteins recognize DNA sequence A. from inside after separation of the double strand B. From outside of the double strand C. by forming hydrogen bonds with bases D. A and C only E. B and C only 6. Specialized cells can be created from the pluripotent stem cells by expressing different gene regulatory proteins or transcription factors A. True B. Fals 7. Methylation of C at CG islands of the genome may cause the following, except A. gene activation B. gene silencing C. heterochromatin formation D. Chromatin condensation E. epigenetic inheritance 8. CG islands are gradually disappearing from the genome except at the promoter site of the active gene because A. unmethylated C is converted to U due to accidental deamination B. methylated C is converted to U due to accidental deamination C. methylated C is converted to T due to accidental deamination D. All of the above E. None of the above 9. Nucleotide of a sequence in DNA where RNA polymerase binds and starts transcription is called A. Shine-Dalgarno sequence B. Operator C. Promoter D. Enhancer E. None of the above 10. A hematologist is studying an African American family as one of the children was recently diagnosed with sickle cell disease. His brother shows no symptoms of the disease, although genetic test showed homozygosity for the HbS gene. An analysis of his red blood cells is likely to show which of the following? A. Reduced alpha chain synthesis. B. Reduced sickle chain synthesis. C. Increased gamma chain synthesis. D. Increased zeta chain synthesis. E. Increased delta chain synthesis. 11. A human genetic condition in which too much of a gene is routinely expressed has been mapped to a locus on a different chromosome from where the gene in question is located. Which one of the following is a potential explanation for the condition? A. The activated gene has a TATA box mutation. B. The locus control region for the gene is deleted. C. A gene encoding a transcriptional repressor has been mutated. D. A transcriptional activator sustained a missense mutation, which rewduces its affinity for DNA E. A variant promoter region is formed owing to a splice site mutation. 12. A long standing patient of yours has developed multiple tumor types during his life (41 yrs old). You have diagnosed him as having a specific syndrome involving p53, which is a transcription factor and tumor suppressor protein. The multiple cancers that result from this syndrome are primarily due to which of the following initial direct effects of the inherited mutation? A. Impaired gene transcription B. Enhanced gene transcription C. Impaired protein synthesis D. enhanced protein synthesis E. altered chromosomal structure.