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Questions and Answers

Which of the following properties is NOT exhibited by an enhancer element?

  • Is functional when located upstream or downstream of the transcription initiation site
  • Promotes the assembly of RNA polymerase and general transcription factors
  • Acts as the binding site for a gene regulatory protein
  • Is functional when located in an intron (correct)
  • What is the main characteristic of gene regulatory proteins?

  • Characteristic enzymatic properties
  • Protease cleavage site
  • A DNA binding domain and an activation domain (correct)
  • A domain necessary for membrane integration
  • What is the main mediator of X-chromosome inactivation?

  • Random recombination
  • Spontaneous genetic mutation
  • Xist RNA-mediated heterochromatin formation (correct)
  • Global translational inhibition during puberty
  • What does the leucine zipper motif of proteins mediate?

    <p>Interaction between two β-sheet structures</p> Signup and view all the answers

    How do gene regulatory proteins recognize DNA sequences?

    <p>From both inside and outside of the double strand</p> Signup and view all the answers

    True or False: Specialized cells can be created from pluripotent stem cells by expressing different gene regulatory proteins or transcription factors.

    <p>True</p> Signup and view all the answers

    Which of the following is NOT caused by methylation of C at CG islands of the genome?

    <p>Gene activation</p> Signup and view all the answers

    Why are CG islands gradually disappearing from the genome?

    <p>They are being deleted during replication</p> Signup and view all the answers

    Which of the following is the correct conversion of unmethylated C due to accidental deamination?

    <p>U</p> Signup and view all the answers

    What is the nucleotide sequence in DNA where RNA polymerase binds and starts transcription called?

    <p>Promoter</p> Signup and view all the answers

    In the case of sickle cell disease, which chain synthesis is likely to be increased in the red blood cells of an individual who shows no symptoms but is homozygous for the HbS gene?

    <p>Gamma chain synthesis</p> Signup and view all the answers

    A human genetic condition where too much of a gene is routinely expressed has been mapped to a locus on a different chromosome from where the gene is located. What is a potential explanation for this condition?

    <p>The locus control region for the gene is deleted</p> Signup and view all the answers

    In a specific syndrome involving p53, which is a transcription factor and tumor suppressor protein, what is the primary cause of multiple cancers resulting from the inherited mutation?

    <p>Impaired gene transcription</p> Signup and view all the answers

    Which of the following is the correct conversion of methylated C due to accidental deamination?

    <p>G</p> Signup and view all the answers

    What is the nucleotide sequence in DNA where RNA polymerase binds and starts transcription called?

    <p>Promoter</p> Signup and view all the answers

    In the case of sickle cell disease, which chain synthesis is likely to be increased in the red blood cells of an individual who shows no symptoms but is homozygous for the HbS gene?

    <p>Gamma chain synthesis</p> Signup and view all the answers

    A human genetic condition where too much of a gene is routinely expressed has been mapped to a locus on a different chromosome from where the gene is located. What is a potential explanation for this condition?

    <p>The locus control region for the gene is deleted</p> Signup and view all the answers

    In a specific syndrome involving p53, which is a transcription factor and tumor suppressor protein, what is the primary cause of multiple cancers resulting from the inherited mutation?

    <p>Impaired gene transcription</p> Signup and view all the answers

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