Practice Questions and Key Suppository PDF

**[Review Questions]** 1\. List ***three*** potential dosing/administration ***advantages*** of suppositories as compared to oral capsules and tablets: 2\. Which of the following is an ***advantage*** of rectal administration? a. Administration is comfortable and convenient b. Provides consist...

**[Review Questions]** 1\. List ***three*** potential dosing/administration ***advantages*** of suppositories as compared to oral capsules and tablets: 2\. Which of the following is an ***advantage*** of rectal administration? a. Administration is comfortable and convenient b. Provides consistent systemic drug absorption c. ***Generally avoids first pass metabolism*** d. b & c e. All of the above 3\. Which of the following may be used to facilitate the disintegration of suppositories after administration? b. Polysorbate 80 c. Ascorbyl palmitate d. Clindamycin 4\. Which of the following statements regarding the preparation of suppositories by molding/fusion is ***true***? a. Always requires the use of density factor calculations b. May be used when dealing with large quantities of powder ingredients c. Should be used when working with heat sensitive drugs d. ***Typically results in pharmaceutically elegant suppositories*** e. Utilizes compression techniques 5\. Which of the following statements regarding the double-casting method for preparing suppositories is ***true***? b. The drug is initially blended with \~1/3 of the melted base c. During the first casting, the drug/base mixture should only be poured into the bottom portion of the suppository molds d. b & c e\. All of the above 6\. A pharmacist just completed the following formula using the double-casting method and determined the blank suppository weight to be 2.72 g and the final suppository weight to be 2.76 g. Using this information, calculate the density factor for acetaminophen in the PEG base: a. 0.5 b. 0.7 c. 1.0 d. 1.4 e. None of the above 7\. A pharmacist just prepared the following prescription using the double-casting method. If the blank individual suppository weight was 2 g and the final individual suppository weight was determined to be 1.95 g, calculate the density factor for zinc oxide in the glycerin base: a. 0.08 b. 0.67 c. 1.50 d. 2.00 e. None of the above 8\. How will overheating cocoa butter influence its physical stability and why is this a concern when preparing suppositories? 9\. Which of the following may be used to minimize the oxidation of fatty suppository bases? 10\. Which of the following statements regarding suppository dosage forms is ***false***? a. b. c. d. e. 11\. Fully describe why the salt form of a drug should be used instead of the non-salt form when preparing cocoa butter suppositories: 12\. Determine the amount of active ingredient and suppository base needed to prepare the following prescription using a balance having a LWQ of 50 mg; both atropine and atropine sulfate are available: *(DF for atropine and atropine sulfate in fatty base are 1.1 and 1.25, respectively; MW for atropine and atropine sulfate are 289 and 674, respectively; molar ratio of atropine to atropine sulfate is 2:1 blank suppository weight for fatty base is 1.3 g)* 13\. Determine the amount of morphine hydrochloride and theobroma oil needed to prepare the following prescription: *(the DF for morphine hydrochloride in theobroma oil is 1.6; the blank suppository weight for theobroma oil is 1.5 g; the MW for morphine is 285.33; the MW for morphine hydrochloride is 321.75; the molar ratio of morphine to morphine hydrochloride is 1:1)* **\ ** **[EQUATIONS AND CONVERSIONS]** ### dC / dt = PS(C~1~ -- C~2~) P = Dk / hV dC/dt = K~m~S(C~1~ -- C~2~) **[Review Questions Answer Key]** 1\. List ***three*** potential dosing/administration ***advantages*** of suppositories as compared to oral capsules and tablets: ***-- LO 1*** 2\. Which of the following is an ***advantage*** of rectal administration? ***-- LO 1*** a. Administration is comfortable and convenient ***(administration is uncomfortable and inconvenient)*** b. Provides consistent systemic drug absorption ***(such absorption is erratic and inconsistent)*** c. ***Generally avoids first pass metabolism*** d. b & c e. All of the above 3\. Which of the following may be used to facilitate the disintegration of suppositories after administration? ***-- LO 2*** b. Polysorbate 80 ***(surfactant)*** c. Ascorbyl palmitate ***(preservative)*** d. Clindamycin ***(drug)*** 4\. Which of the following statements regarding the preparation of suppositories by molding/fusion is ***true***? ***-- LO 3*** a. Always requires the use of density factor calculations ***(not necessary for double casting)*** b. May be used when dealing with large quantities of powder ingredients ***(large powder quantities may make the base mixture too viscous to pour and mold)*** c. Should be used when working with heat sensitive drugs ***(molding requires heat)*** d. ***Typically results in pharmaceutically elegant suppositories*** e. Utilizes compression techniques ***(uses molding, not compression)*** 5\. Which of the following statements regarding the double-casting method for preparing suppositories is ***true***? ***-- LO 3*** b. The drug is initially blended with \~1/3 of the melted base c. During the first casting, the drug/base mixture should only be poured into the bottom portion of the suppository molds d. b & c ***e. All of the above*** 6\. A pharmacist just completed the following formula using the double-casting method and determined the blank suppository weight to be 2.72 g and the final suppository weight to be 2.76 g. Using this information, calculate the density factor for acetaminophen in the PEG base: ***-- LO 5*** a. 0.5 b. 0.7 c. 1.0 d. ***1.4*** e. None of the above 7\. A pharmacist just prepared the following prescription using the double-casting method. If the blank individual suppository weight was 2 g and the final individual suppository weight was determined to be 1.95 g, calculate the density factor for zinc oxide in the glycerin base: ***-- LO 5*** a. 0.08 b. ***0.67*** c. 1.50 d. 2.00 e. None of the above 8\. How will overheating cocoa butter influence its physical stability and why is this a concern when preparing suppositories? ***-- LO 6*** 9\. Which of the following may be used to minimize the oxidation of fatty suppository bases? -- ***LO 6*** 10\. Which of the following statements regarding suppository dosage forms is ***false***? ***-- LO 7*** a. Can be prepared using either fusion, hand-rolling, or compression methods b. Could be dipped in water before insertion to help improve performance c. Include little or no water and therefore have a relatively good chemical stability d. May be described as solid bodies of various weights and shapes adapted for introduction into the rectal, vaginal, and urethral orifices of the body e. ***Provide a great deal of dosing flexibility (unit-dose and size limitation restrict dosing flexibility)*** 11\. Fully describe why the salt form of a drug should be used instead of the non-salt form when preparing cocoa butter suppositories: ***-- LO 7*** 12\. Determine the amount of active ingredient and suppository base needed to prepare the following prescription using a balance having a LWQ of 50 mg; both atropine and atropine sulfate are available: *(DF for atropine and atropine sulfate in fatty base are 1.1 and 1.25, respectively; MW for atropine and atropine sulfate are 289 and 674, respectively; molar ratio of atropine to atropine sulfate is 2:1 blank suppository weight for fatty base is 1.3 g) **-- LO 4 & 8*** ***1.75 mg/1 supp x 32 supp (two extra to account for loss) = 56 mg atropine*** ***[674 mg AS] x [1 mmol AS] x [1 mmol A] x 56 mg A = 65 mg AS*** ***1 mmol AS 2 mmol A 289 mg A*** ***[1 g FB]** **x 0.065 g AS = 0.0522 g FB*** ***1.25 g AS*** 13\. Determine the amount of morphine hydrochloride and theobroma oil needed to prepare the following prescription: *(the DF for morphine hydrochloride in theobroma oil is 1.6; the blank suppository weight for theobroma oil is 1.5 g; the MW for morphine is 285.33; the MW for morphine hydrochloride is 321.75; the molar ratio of morphine to morphine hydrochloride is 1:1) **-- LO 4 & 8*** ***125 mg/25 supp x 27 supp (two extra to account for loss) = 135 mg morphine*** ***[321.75 mg MHCl] x [1 mmol MHCl] x [1 mmol M] x 135 mg M = 152 mg MHCl*** ***1 mmol MHCl 1 mmol M 285.33 mg M*** ***[1 g TO]** **x 0.152 g MHCl = 0.095 g TO*** ***1.6 g MHCl***