Endothelial-Leukocyte Adhesion Molecules PDF
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This table details Endothelial-Leukocyte Adhesion Molecules, and their roles in the binding of circulating T-lymphocytes to the high endothelial venules in lymph nodes and mucosal lymphoid tissues, and subsequent "homing" of lymphocytes to these tissues. The table categorizes molecules based on their role in rolling, adhesion, transmigration, and leukocyte migration.
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## TABLE 2-1 Endothelial-Leukocyte Adhesion Molecules | Endothelial Molecule | Leukocyte Molecule | Major Role | |---|---|---| | P-selectin | Sialyl-Lewis X-modified proteins | Rolling (neutrophils, monocytes, T lymphocytes) | | E-selectin | Sialyl-Lewis X-modified proteins | Rolling and adhesion (...
## TABLE 2-1 Endothelial-Leukocyte Adhesion Molecules | Endothelial Molecule | Leukocyte Molecule | Major Role | |---|---|---| | P-selectin | Sialyl-Lewis X-modified proteins | Rolling (neutrophils, monocytes, T lymphocytes) | | E-selectin | Sialyl-Lewis X-modified proteins | Rolling and adhesion (neutrophils, monocytes, T lymphocytes) | | GlyCam-1, CD34 | L-selectin* | Rolling (neutrophils, monocytes) | | ICAM-1 (immunoglobulin family) | CD11/CD18 (B2) integrins (LFA-1, Mac-1) | Adhesion, arrest, transmigration (neutrophils, monocytes, lymphocytes) | | VCAM-1 (immunoglobulin family) | VLA-4 (B1) integrin | Adhesion (eosinophils, monocytes, lymphocytes) | | CD31 (PECAM) | CD31 | Leukocyte migration through endothelium | *L-selectin is expressed weakly on neutrophils. It is involved in the binding of circulating T-lymphocytes to the high endothelial venules in lymph nodes and mucosal lymphoid tissues, and subsequent "homing" of lymphocytes to these tissues.
