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Endothelial-Leukocyte Adhesion Molecules Quiz

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Endothelial-Leukocyte Adhesion Molecules Quiz

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Questions and Answers

What is the primary function of P-selectin in endothelial-leukocyte interaction?

Adhesion of leukocytes

Transmigration of leukocytes

Activation of leukocytes

Rolling of leukocytes (correct)

Which endothelial molecule is specifically associated with E-selectin?

ICAM-1

CD31

Sialyl-Lewis X-modified proteins (correct)

VLA-4 integrin

What role does ICAM-1 play in the interaction between endothelial cells and leukocytes?

Activation of eosinophils

Homing of T-lymphocytes

Adhesion and transmigration of leukocytes (correct)

Rolling of neutrophils

Which leukocyte molecule interacts with VCAM-1?

<p>VLA-4 integrin</p> Signup and view all the answers

Which of the following is true regarding L-selectin?

<p>It plays a role in the rolling of neutrophils and monocytes.</p> Signup and view all the answers

Study Notes

Endothelial-Leukocyte Adhesion Molecules

P-selectin: Bound to Sialyl-Lewis X-modified proteins, involved in rolling of neutrophils, monocytes, and T lymphocytes.
E-selectin: Bound to Sialyl-Lewis X-modified proteins, involved in rolling and adhesion of neutrophils, monocytes, and T lymphocytes.
GlyCam-1, CD34: Bound to L-selectin, involved in rolling of neutrophils and monocytes.
ICAM-1 (immunoglobulin family): Bound to CD11/CD18 (β2) integrins (LFA-1, Mac-1), involved in adhesion, arrest, and transmigration of neutrophils, monocytes, and lymphocytes.
VCAM-1 (immunoglobulin family): Bound to VLA-4 (β1) integrin, involved in adhesion of eosinophils, monocytes, and lymphocytes.
CD31 (PECAM): Involved in leukocyte migration through endothelium.
L-selectin: Expressed weakly on neutrophils, plays a role in binding circulating T-lymphocytes to high endothelial venules in lymph nodes and mucosal lymphoid tissues, facilitating lymphocyte "homing" to these tissues.

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Description

Test your knowledge on the key adhesion molecules involved in the interaction between endothelial cells and leukocytes. This quiz covers important molecules like P-selectin, E-selectin, ICAM-1, and VCAM-1, focusing on their roles in immune responses and cell migration. Perfect for students of immunology or vascular biology.