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Endothelial-Leukocyte Adhesion Molecules Quiz

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Endothelial-Leukocyte Adhesion Molecules Quiz

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Questions and Answers

What is the primary function of P-selectin in endothelial-leukocyte interaction?

Adhesion of leukocytes
Transmigration of leukocytes
Activation of leukocytes
Rolling of leukocytes (correct)

Which endothelial molecule is specifically associated with E-selectin?

ICAM-1
CD31
Sialyl-Lewis X-modified proteins (correct)
VLA-4 integrin

What role does ICAM-1 play in the interaction between endothelial cells and leukocytes?

Activation of eosinophils
Homing of T-lymphocytes
Adhesion and transmigration of leukocytes (correct)
Rolling of neutrophils

Which leukocyte molecule interacts with VCAM-1?

<p>VLA-4 integrin (B)</p> Signup and view all the answers

Which of the following is true regarding L-selectin?

<p>It plays a role in the rolling of neutrophils and monocytes. (A)</p> Signup and view all the answers

Flashcards

P-selectin

P-selectin is an endothelial molecule that binds to sialyl-Lewis X modified proteins on leukocytes, leading to rolling.

E-selectin

E-selectin is an endothelial molecule that binds to sialyl-Lewis X modified proteins on leukocytes, leading to both rolling and adhesion.

ICAM-1

ICAM-1 is an immunoglobulin family member expressed on endothelial cells. It binds to CD11/CD18 integrins on leukocytes, leading to firm adhesion and transmigration.

VCAM-1

VCAM-1 is an immunoglobulin family member expressed on endothelial cells. It binds to VLA-4 integrins on leukocytes, leading to adhesion.

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CD31 (PECAM)

CD31 (PECAM) is an endothelial molecule that binds to itself on leukocytes, facilitating leukocyte migration through the endothelium.

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Study Notes

Endothelial-Leukocyte Adhesion Molecules

P-selectin: Bound to Sialyl-Lewis X-modified proteins, involved in rolling of neutrophils, monocytes, and T lymphocytes.
E-selectin: Bound to Sialyl-Lewis X-modified proteins, involved in rolling and adhesion of neutrophils, monocytes, and T lymphocytes.
GlyCam-1, CD34: Bound to L-selectin, involved in rolling of neutrophils and monocytes.
ICAM-1 (immunoglobulin family): Bound to CD11/CD18 (β2) integrins (LFA-1, Mac-1), involved in adhesion, arrest, and transmigration of neutrophils, monocytes, and lymphocytes.
VCAM-1 (immunoglobulin family): Bound to VLA-4 (β1) integrin, involved in adhesion of eosinophils, monocytes, and lymphocytes.
CD31 (PECAM): Involved in leukocyte migration through endothelium.
L-selectin: Expressed weakly on neutrophils, plays a role in binding circulating T-lymphocytes to high endothelial venules in lymph nodes and mucosal lymphoid tissues, facilitating lymphocyte "homing" to these tissues.

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Description

Test your knowledge on the key adhesion molecules involved in the interaction between endothelial cells and leukocytes. This quiz covers important molecules like P-selectin, E-selectin, ICAM-1, and VCAM-1, focusing on their roles in immune responses and cell migration. Perfect for students of immunology or vascular biology.