Pharmacology Final Review Questions PDF

Pharmacology Final Review Questions with answers Q1&2 , F 1) Which of the following drug is eliminated in alkaline urine? A) Paracetamol B) Amphetamine C) Diclofenac D) Sulfonamide 2) Which of the following is an enzyme inhibitor? A) Testosterone B) Tobacco smoking C) Ethyl alcohol D) Estrogen 3) Wh...

Pharmacology Final Review Questions with answers Q1&2 , F 1) Which of the following drug is eliminated in alkaline urine? A) Paracetamol B) Amphetamine C) Diclofenac D) Sulfonamide 2) Which of the following is an enzyme inhibitor? A) Testosterone B) Tobacco smoking C) Ethyl alcohol D) Estrogen 3) What phenomenon can occur in the case of using a combination of drugs? A) Accumulation B) Synergism C) Tachyphylaxis D) Tolerance 4) Which receptor could be activated by noradrenaline? A) Dopaminergic receptors B) Alfa receptor C) Both alfa and beta receptors D) Beta receptor 5) Which of the following statements is correct about Isoproterenol? A) Parasympathomimetic directly acting on the nicotinic receptor. B) Parasympathomimetic directly acting on the muscarinic receptor. C) Sympathomimetic directly acting on the alfa-adrenergic receptor. D) Sympathomimetic directly acting on the beta-adrenergic receptor. 6) Which of the following drug is eliminated in acidic urine? A) Phenobarbitone B) Paracetamol C) Amphetamine D) Diclofenac 7) Which of the following is a local hemostatic, Nasal decongestant direct- acting catecholamine? A) Adrenaline B) Phentolamine C) Amphetamine D) Ephedrine 8) What does the term "bioavailability" mean? A) Amount of a substance in urine relative to the initial dose B) Plasma protein binding degree of substance C) Fraction of an uncharged drug reaching the systemic circulation following any route administration D) Permeability through the brain-blood barrier 9) What type of drug-drug interaction relates to absorption, biotransformation, distribution, and excretion processes? A) Pharmacodynamic interaction B) Physical and chemical interaction C) Pharmaceutical interaction D) Pharmacokinetic interaction 10) Which of the following route of drug administration is preferred for administering a drug directly into the spinal cord? A) Intra-arterial route B) Intravenous route C) Subcutaneous route D) Intra-thecal route 11) What type of drug-drug interaction results from interaction at the receptor, cell, enzyme, or organ level? A) Pharmacodynamic interaction B) Physical and chemical interaction C) Pharmaceutical interaction D) Pharmacokinetic interaction 12) Which of the following could better define "Conjugation"? A) Process of drug hydrolysis by hydrolytic enzymes B) Process of drug oxidation by special oxidases (CYP450) C) Coupling of a drug with an endogenous substrate as glucuronic acid D) Process of drug reduction by special enzymes 13) Which of the following could define the drug's half-life (t ½)? A) The time required to metabolize half of an introduced drug into the active metabolite B) The time required to absorb half of an administered drug C) The time required to bind half of an administered drug to plasma proteins D The time required to reduce the amount of a drug in plasma by half during the elimination 14) Which of the following best refers to the bioavailability of a drug? A) Percentage of the administered dose that reaches the systemic circulation in the unchanged form B) The ratio of drugs excreted unchanged in urine to eliminated as metabolites C) The ratio of oral to parenteral dose D) The ratio of the orally administered drug to that eliminated in the feces 15) Which of the following statement could define an agonist? A) A drug interacts with the receptor and initiates changes in cell function, producing various effects. B) A drug increases the concentration of another substance to produce an effect. C) A drug interacts with the receptor without producing any effect. D) A drug interacts with plasma proteins and doesn't produce any effect. 16) Which drug activates Dopaminergic (D1 and D2) and adrenergic (alfa and beta) receptors? A) Dobutamine B) Phenylephrine C) Dopamine D) Methoxamine 17) Which of the following could refer to the term "chemical antagonism"? A) One drug combines with one another to form an inactive compound B) One drug combines with one another to form a more fat-soluble compound C) One drug combines with one another to form a more water-soluble compound D) One drug combines with one another to form a more active compound 18) Which of the following is more likely to be used as a nasal decongestant? A) Dobutamine B) Clonidine C) Isoprenaline D) Adrenaline 19) Which of the following statements could define "Pharmacodynamics"? A) Absorption and distribution of the drug B) The effect of the body on the drug C) The effect of the drug on the body D) Biotransformation and execration of the drug 20) Which of the following is noncatecholamine dual-acting adrenergic drugs which induce tachyphylaxis? A) Propranolol B) Amphetamine C) Phentolamine D) Ephedrine 21) What are the reasons for determining bioavailability? A) The oral dose and frequency of the drug B) Physiological parameters of blood C) The extent of absorption and hepatic first- pass effect D) Glomerular filtration rate 22) Which of the following acts by enhancing the release of noradrenaline? A) Cocaine B) Ephedrine C) Guanethidine D) Amphetamine 23) Which receptor could be activated by isoprenaline? A) Alfa receptor B) Dopaminergic receptors C) Beta receptor D) Both alfa and beta receptors 24) Which type of drugs could be rapidly excreted by the alkalinization of urine? A) Weakly basic drugs B) Weakly acidic drugs C) Nonpolar drugs D) Strong electrolytes 25) Which effect may lead to toxic reactions when a drug is taken continuously or repeatedly? A) Tolerance B) Idiosyncrasy C) Tachyphylaxis D) Cumulative effect 26) Which among the given drugs is metabolized by MAO and COMT? A) Acetylcholine B) Amphetamine C) Adrenaline D) Ephedrine 27) Which of the following drugs is used for the prolongation of action of local anesthetics? A) Adrenaline B) Tubocurarine C) Acetylcholine D) Muscarine 28) Which of the following results from the drug biotransformation? A) High binding affinity to cellular membranes B) Faster urinary excretion C) Slower urinary excretion D) High binding affinity to plasma protein 29) Which type of drug interaction will occur If two drugs with the same effect, taken together, produce an effect equal in magnitude to the sum of the effects of the medications given individually? A) Additive effect B) Accumulation C) Antagonism D) Potentiation 30) Which of the following is an enzyme inducer? A) Chloramphenicol B) Cimetidine C) Grape juice D) Testosterone 31) Which of the following agents is a less lipophilic, more potent histamine receptor subtype-1 blocker with no central action and no atropine-like activity? A) Cimetidine B) Cetirizine C) Cyproheptadine D) Diphenhydramine 32) Which of the following agents acts as an ecbolic drug used to induce parturition or abortion and control postpartum hemorrhage? A) Zileuton B) Zafirlukast C) Celecoxib D) Prostaglandin F2-alpha 33) Which of the following could treat both atropine and curare toxicity? A) Acetylcholine B) Muscarine C) Neostigmine D) Noradrenaline 34) Which of the following agents is of insignificant value in for treatment of peptic ulcer? A) Hydrocortisone B) Betamethasone C) Zileuton D) Diphenhydramine 35) Which of the following analgesic agents is safe to be used during pregnancy? A) Diclofenac B) Paracetamol C) Celecoxib D) Ketoprofen 36) Which of the following agents is a 5-HT agonist with antianxiety activities? A) Olanzapine B) Cyproheptadine C) Ondansetron D) Buspirone 37) Which of the following drugs is recommended for the treatment of carcinoid tumor in a 72-old lady and acts by blocking 5- HT receptors? A) Dexamethasone B) Diphenhydramine C) Misoprostol D) Cyproheptadine 38) Which of the following antispasmodic agents with muscarinic-blocking activities? A) Hyoscine butyl bromide B) Physostigmine C) Benztropine D) Homatropine 39) Which of the following agents is considered physiological antagonist histamine? A) Cimetidine B) Diphenhydramine C) Glucocorticoids D) Adrenaline 40) Which of the following drugs is considered a parasympatholytic agent and could be used for examining the eye fundus due to its mydriatic effects? A) Atropine B) Adrenaline C) Ephedrine D) Amphetamin