Pharmaceutical Calculation Lab 4 PDF

Pharmaceutical calculation Simple solution Lab. 4 Assist. Lec : Alhasan Ali Jabbar Solutions are liquid pharmaceutical preparations. Which contain one or more soluble chemical substance dissolved in one or more suitable solvent and produce Single p...

Pharmaceutical calculation Simple solution Lab. 4 Assist. Lec : Alhasan Ali Jabbar Solutions are liquid pharmaceutical preparations. Which contain one or more soluble chemical substance dissolved in one or more suitable solvent and produce Single phase system. We have two types of solution : General procedure of preparation of simple solution 1 Weigh the solid ingredient and put it in a beaker. 2 Subtract the volume of liquid ingredient (in the formula) from ¾ of the final volume of the prescription. 3 Dissolve the solid ingredients in the remaining amount of the vehicle. 4 Add the liquid ingredient. 5 Convert the content of the beaker into the measuring cylinder and complete the volume up to the required amount by the addition of the vehicle. 6 Transfer the content of the measuring cylinder to a wide mouth bottle and put the suitable label. Rx name Rx date Name of patient Name of physician Uses White label for internal use, purple or red for external use.  Examples 1: NaCl 25 mg Water q.s. 200 ml Calculation : 200 ml x 3/4 = 150 ml of water will be used to dissolve NaCl initially. Procedure : 1. Weigh 25 mg of NaCl 2. Measure 150 ml of water and place it in a beaker 3. Dissolve the NaCl in the beaker with stirring 4. Transfer to the graduated cylinder and complete the volume with water to 200 ml 5. Transfer to the suitable container and label it.  Examples 2 : NaCl. 50mg Coloring agent. 10ml Water q.s. 100ml Calculations: 100 x 3/4 =75ml 75ml -10ml =65ml of water will be used to dissolve NaCl initially. Procedure: 1. Weigh 50 mg of NaCI 2. Measure 65 ml of water and place it in a beaker 3. Dissolve the NaCl in the beaker with stirring 4. Add 10 ml of the coloring agent and mix 5. Transfer to the graduated cylinder and complete the volume with water to 100 ml 6. Transfer to the suitable container and label it.  Procedure: 1. Weigh 0.45gm of NaCl and put it in a beaker. 2. Dissolve the NaCl in 36.5ml of D.W. 3. Add 1ml of amaranth solution to the mixure. 4. Convert the content of the beaker into measuring cylinder and complete the volume to 50ml by D.W. 5. Transfer the content of the measuring cylinder into a wide mouth bottle and put the suitable label. Percent Means by hundred or in a hundred. It may be expressed as a ratio, represented as a common or decimal fraction.The ratio usually changes to decimal by dividing the number by 100.Example: 30% = 30/100 =0.3  Percentagemeans rate per hundred so 50% and percentage of 50 are equivalent expressions. There are three types of percentage: 1. Weight/Weight: it expresses the number of grams of the active ingredient in 100 gram of solution. 2. Weight/Volume: it expresses the number of grams of active ingredient in 100 milliliter of solution. 3. Volume/Volume: it expresses the number of milliliter of active ingredient in 100ml of solution.  Procedure 1. Weigh 3gm of glucose and 0.9 g of NaCl and 0.6 g of KCI by using balance then put it in a beaker. 2. Dissolve the active ingredient in 22.5mL of D.W. 3. Convert the content of the beaker into a measuring cylinder and complete the volume to 30ml by D.W. 4. Transfer the content of the measuring cylinder into wide mouth bottle and put a suitable label.  Homework How many grams of glycerin should be used to prepare 250g of 5% w/w solution ?  Reducing and Enlarging Formulas In pharmaceutical preparation, pharmacist may have to reduce or enlargethe formula and maintain the right proportion of each ingredient in theprescription. Quantity of formula desired / Quantity of formula given = F The quantity of each ingredient then multiplied by the factor F to get therequired quantity.  Rx Calamine 150gm Zine oxide 50gm Bentonite 30gm Liquefied phenol. 5ml Glycerin 50 ml D.W. q.s. to 1000 ml Ft. mitte 250 ml Calculation : = 0.25 Calamine 150 gm x 0.25 = 37.5 gm Zine oxide 50 gm x 0.25 = 12.5 gm Bentonite 30 gm x 0.25 = 7.5 gm Liquefied phenol 5 ml x 0.25 = 1.25 ml Glycerin 50 ml x 0.25 = 12.5 ml 250ml X 3/4 - (1.25+12.5) = 187.5 -13.75 = 173.75  Procedure: 1. Weigh each solid ingredient alone and put in a beaker 2. Measure 174 ml of water and place it in a beaker to dissolve the solid substances with stirring 3. Add 1.25 ml of liquefied phenol and 12.5 ml of glycerin to a beaker with stirring 4. Transfer to the graduated cylinder and complete the volume with water to 250 ml 5. Transfer to the suitable container and label it.  Procedure: 1. Weigh 1 gm of sodium bicarbonate and put in a beaker 2. Measure 44.5 ml of water and place it in a beaker to dissolve the sodium bicarbonate with stirring 3. Add 0.5 ml from Tr. Of cardamom to a beaker with stirring 4. Transfer to the graduated cylinder and complete the volume with water to 60 ml 5. Transfer to the reagent bottle and put label. Thank you