Pharma 1 Section 2 PDF

SUB DATE phalma 1 Sec tion2 g J nervoussystem Le Sst cwgS mouseJlCauSo heartLe Ls> (2 Male lFemal...

SUB DATE phalma 1 Sec tion2 g J nervoussystem Le Sst cwgS mouseJlCauSo heartLe Ls> (2 Male lFemale os animal co gis (L Route ae administratiugosmost Commonij dose e mouSe,I.p  DATE mVitality 21Heart rate Yange 4,Resciratsrrates normal a animal ane 5\Gait The wa the animcll moVe. EJe hall (mousej Dupilsize(Froq) heFlexeSs )Dain eflex 2 RishtngYeglex 3) Colneal efleh&sl mauselc o l laSS rod Nile  SUB DATE 6)Fcketon waste praluct SccletinagoonSalva Jlsj s Laclb animal anias Jcll bSosle cLl Ne vous system CNS PNS Brain Sena) Somatic Cord Autonomtc Parasympthetic yma thetic Perleheal nervous S9stemgS9ne lnetvesLjoasgas bainJi Seingl Jlo otherargansJ seinalJlg brain úo Cord Somatic nervousSystemgSteletalmuscle morenentci Skin JIJSjoSensatiohJl Aotonomc nefvous systemginvoluntar Jl,espiratory Peristalsis rate , hestttate sli (aut o fatient Conscious  SUB DATE AutonomicnerVous system N.S Datasyfathetic Syafthetics d Sacal s (=thotaco-lumbefi (= ctanio = Rest and digest -Fightand Flight LThe A.S Ptedominatesin Lerelorni natesoverthe rest condítions. body in Fedr Condtion S + Alloragansin the body have dual sueeg of Potasym QarthetiCand symPathetiCEXc Pte 1)Sueatena) land 2)Sw eat aland 3)Rloodvessels bssolsatSu ylefl cac notnac state Prafasnothetic SUmathetic HeatYate decleaSe \ncrease Respitatory decrease fate ncreage (broncho Consttiction)(brochodíaloc Secretions Incease Peristalsls dhecreaSe increase decrease EXcfetion incease dechease  SUB DATE Somatic nerve OMyleinatedl No 9ang lia Parasyrpathetic genore S9mPathetic Ge Iarionic fiber gangla +ermnals S39acetl Chaine (AChese re nerveJ signat LLa Lobo Lo NegictesJ recePtor&gangiaJ bguss elinehrine snoreplnehine nicotinicacetylCholine t line (adrenalinenorcerena Chariael Lotaeceetorsll cmt intothe nerve of Nat Cell sf:rirg (asde,BsBeG) of deQolarization, tgan jos, Signal he slo signaJ1Jaa terminals JleAch release ass 9 Ach S nerve tefrino t aryanl, Guasalal ály dalsllaleSsynae recetor ogan  SUB DATE ParasymPathetic SymPatheticeit near tothe ot9an nearto therecteA Siteop Jangha column (vertebtal gana|38 neurotansmittert Ach Ach Sangrionic syhapse nicotinic nicotinic(nAch) (nfch receptoingargla Ach gnoelnephr ePinehr'ne at neulotansmitter Sweat qland (exceptjn synaps Pstgaronic Ach) inthetisuMuscorinic receftor Adceneroc (MinMzgMa) J dePolarization Preganglisnic Fiber alo S,3i9nalJL S(actisnPstential) of neutonS. Gan9lia Colectian M, receptorstimlated by Ach(eataSSemPathoti + Heart has B, recepto "Smpathetic hugsaysthree classescs I Paasymfathetic drhgs aS 2bu9s acton autonokaicganglia.  SUB DATE dtagszoRalasymCsthomimeticdrugs xalaSymfAthetic QParasyaPathaytic dregs OPalasympathoimeticdtugs. bDlags Stimulatethe n.s efFect Palasym@ath etic ditect1y inditrectly b9 jncleqsing Sectetion -preventdegadationofAeh 5 f Ach Pom netvetelminals. eceptoJ[daAch 5-dugs to Ach. Similar 6dsoias ot@jbiic lectUI Slenzyme Jlaiaisssagl.acetylcholine eStofase 9l h JI DilectDarasymathuimetic ahgsa QcholineeStel - Ach DCholinomimetic dhugs 2- CarbaCo| Plocarpin 3-Methacoline 2-(Muscarne (natural alKaloids Indirect Paosyo@atho mimeticdhgs: Articholine esterase: I-ReVersible eAFeCtye9:PhSostßmine 2-Irreversible effecter Or9ano ChosPhotous 3 Choline esterase lfalaealsL CormPounds linsectici aao cholineeSteaell Nile  DATE PloCakPinebelongs fo:Class Patasymfinomiangti Subclass Cholinenaimethc Arug System fecePtor heartrate e o ParasymPatheti teseiratory rute (bronchoConStriction) , Secretlon eXcetion feseiratory Failureal lka2 Gzlo Nile  DATE (Qrala SJmfthol9tic dugs: blocKing of muscafinic teceptos o Atopire brady arhythmias 2ScoPolamine ate asiüiantiemet.Blot ics_ýs  SUB DATE ganglaion selective CDugs act on utonomic StStes and Sybafathetic Sypathetic dYascaPPe ct both Pala to be uset) So_not PreferrGd 40GanglionícStimulantS and SynPathetic LincleaSetheefectolboth paasymfathetic. -NiCotine au nerVesge anlonerves losorgans lGas aáss5sli Ga lsGasQarasPathetic nicotires heaftl dy3ias ädL S Lsssi Petstalsis nicotineslb c Syathetl heatejaealg inheattehis inciease rate úans 2- Lobeline blscker blockekr Ganglionic L decreaße the fRecto both PhoSymPothetic and SH mQathetic. egi HeXamethonium Ne  SUB DATE 0Sym fathomimeticdhgs *SymPatheticd g3: l9tíc 0 Symfths orugs OSy dugs: thomimetic -dags Stizulate diecttyor the symRrtheticefpect. inaitect) E9: noadenaline,do amine and ephedrine F)A aperoved For critical hyPotension S3mfatholyic dlagss -Drags decieasethe sympatheticefpect. TpeSe 0Alph- adtenerdicblockers bockers Beta-adreneraic Alphaand beta bloc kers Q Apha- adrenergicblockers inhbitors:Prazosi teazosihand , doXaZoS in yz blocker: yohiabine Beta-adrenergicblockers ; ,atenolo| Praprano\al Carvedí lol ara e ALPh and beta blocker: Labetalol  Drug name;-Pilocarpine Species;Mouse Sex;-male Item Before After adminstrationadminstration vitality normal decrease Excitablity normal decrease Heartrate normal decrease Respiratory rate normal decrease Gait normal normal posture normal normal Eye ball (Mice) normal Miosis Pupilsize(frog) Reflexes "painreflex present present reflexpresent *Righting present *cornealreflex present present reflex *light presentc present *touch reflex present present Excretion Normal increase Secretion Normal increase  Onsettime; 10.min pecularities, o Generalized increase insecretion(salivation&lacrymti and moistendhair o Generalizedincrease inexcretion (urination & defecation o Piloerection sBo40 ears appearonfiter Conclusion:Group Autonomic drug (parasympathetic)Parasympathomimetic Sub Group ;Cholinomimetic alkaloid name of.drug may be pilocarpine  Drug name; Nicotine Species: frog Item Before After adminstration adminstration Vitality normal increase Excistability normal Heartrate normal OCCincrease Increase thendecrease after tremor increase Intial then ratenormal Respiratory decrease Gait normal normal posture normal Abnormal (characteristic)  protrusion of Eye ball(mice) Normal Slight eye ball (miosis then Pupilsize(frog) mydriasisthen miosis Reflexes Painreflex Present Present reflex Present Righting Present(impaired duringtremors Cornealreflex Present Present Lightreflex Present Present Touch reflex Present Present Excretion Increase during tremors Secretion Increase during tremors  ; Onsettime lessthan 1 min pecularities Initial stimulation (indicated by rapidtremorin all extremities )followed by depression Secretion increase especially milky secretion. O Tachycardia OMuscletremors& twichesappearinthe phalangesinofhindlimb Conclusion; Group;Autonomicdrug. (actingon autonomicganglia) Sub Group.Gahoionic simulant may be nicotine Name of he drug: