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Exam 1 IMMUNE Antiinflammatory Agents - Salicylates (Aspirin) Mild-moderate pain , inflammating...

Exam 1 IMMUNE Antiinflammatory Agents - Salicylates (Aspirin) Mild-moderate pain , inflammating conditions , Stroke ↓ risk fo MI risk , Caution : Bleeding disorders Reye's , syndrome, impaired renal func. NIV , heartburn , tinnitus , Reye's syndrome, acidosis - NSAIDS (Ibuprofen) Relieves/s of rheumatoid arthritise Osteoporosis , mild-moderate pain relief, fever reducer Caution : CV dysfunc , HAN , renal/ hepatic dysfunc Headache , dizzy MI stroke BMS, constipation , , , - NSAIDS (Acetaminophen) Mild-moderate symp , musculoskeletal pain cold/fl , pain Caution : Chronic Alcoholism Rash fever , , liver tox/failure , BMS Antiarthritis - Gold compound (Auranofin) Adults w/ rheumatoid arthritis Caution : Diabetes CHF , HTN , renal/ hepatic dysfunc , BMS renal, tox dermatitis , , N/V , stomatitis  - INF blockers (Entanercept) ↓ S/S rheumatoid arthritis juvenille , arthritis psoriatic , arthritis , ankylosing spondylitis plaque psoriasis , Caution : Acute infection , cancer sepsis , MI , Failure , HAN A Made from Chinese hamster or any products * Teratogenic Antigout - Colchine Gout flares Caution : Renal/hepatic dysfunc , Gl upset rhabdomyolosis blood dyscrasias , , Immune Stimulants - Interferous (Interferon Alfa-2b) Haing cell Leukemia , malignant melanoma AIDS , sarcoma, chronic hep B+ C Caution : CV disease, myelo supression CNS anorexia duy Skin , BMS , flu-like symp. , , - Interleukins (Aldesleukin) Metastatic renal cell carcinoma, metastatic melanoma Caution : E Coli. products pregnancy renal/liver / CV dysfunc , , CNS BMS , , Sinus tachy arrythmmia hypotension,dizzy GI bleed , , , - Colony Stimulating Factors (Filgrastim) V Infection risk for chemo pt , Bone marrow transplants Caution : E Coli. products Headache ,fatigue, alopecia , N/V , bone pain Immune Suppresants - T B Cell + Suppressors (Cyclosporine) Prophylactic for organ transplant , organ rejection, rheumatoid arthritis Caution : Teratogenic , Cancer Tremors HAN , , gingeral hyperplasig BMS , , acne - Monal Clonal Antibodies (Bevacizumab) Metastatic Colorectal cancer , lung can cer glioblastoma , , renal cell carcinoma , cervical/ovarian cancer Caution : Fever, teratogenic G perf., headache , hemmorhage VACCINES Active immunity : Immune system protects you from a pathogen Passive Immunity Body gets immunity : from another source (breastmilk, meds) - MMR Vaccine Immunization against MMR Fever rash , , injection site irritation , high fever  - Immune Globulin Prophylaxis against Hep. A , MMR Tenderness angioedema N/V , , , chills Fever , CHEMOTHERAPUTIC Antibiotics - Aminoglycosides (Gentamicin) Serious infections /+ suceptible bacteria Caution Nephrotoxic : , renal disease , preexisting hearing loss Hypersensitivity , Sinusitis , dizzy fever , nephrotoxicity ototoxicity , , - Carbapenems (Ertapenem) Community acquired pneumonia , Gl infections skin infections , Caution : Poor renal function Headache , dizzy N/V pseudo membranous , , colitis Cephalosporins (Cefactor) - Respiratory, dermatologic , urinary tract , and middle ear infections Caution : Allergy to penicillin , hepatic/renal impairment N/V , superinfection , BMS, rash - Fluoroquioones (Ciprofloxacin) Respiratory , dermatologic , UM , ear , eye , bone/joint infections, fever anthrax exposures , typhoid , plague Caution : Boxed warning- tendonitis , tendon rupture CNs effects , Headache hypotension , , N/V , fever  - Penicillins (Amoxicillin) Infections from susceptible bacteria heliobacter infection , Caution : Penicillin allergy NIV glossitis , , BMS , superinfection lethargy , - Sulfonamides (Trimethoprim-sulfamethoxazole/Cotrimoxazole) UTI , acute otitis media chronic bronchitis , , traveller's diarrhea Caution : Older adults Kidney stones, teratogenic, N/V hepatocellular necrosis nematuria hyperkalemia , , , , BMS SJS , - Tetracyclines (Tetracycline) Susecptible bacteria infections , acne , penicillin contradiction N/V , glossitis discoloring teeth , in kids less than 8 BMS , , superinfection - Leprostatic drugs (Isoniazid) TB treatment prevention , in family members Caution Severe renal / hepatic disease : Peripheral neuropathy, N/V BMS, hepatitis, gynecomastia , - Lincosamides (Clindamycin) Serious infections Caution : Hepatic impairment N/V BMS, pseudomembranous colitis , - Lipoglycopeptides (Vancomycin) Septicemia , infective endocarditis skin infections bone infections, , , lower RT infections C-diff , Nephrotoxicity,ototoxicity, hypokalemia  - Macrolides (Erythromycin) Respiratory dermatologic , , UT , G) infections Caution Hepatic dysfunc: NIV superinfection hearing loss pseudo membranous , , , colitis - Oxazolidinones (Linezolid) Resistant bacterial infections pneumonia , , skin infections, diabetic foot infections Caution : Hepatic impairment, HTN hyperthyroidism,BMS , NIV pseudomembranous , colitis * Avoid tyramine foods - Monobactams (Aztreonam) Lower RT derm UTI , , , abdominal , gynecological infections Caution : Penicillin/cephalosporin allergy hepatic dysfunc , N/V superinfection , , anaphylaxis Antivirals - Influenza A agent (Oseltamivir) Influenza A-B treatment Headache N/V , , rash - Herpes& Cytomegalovirus agent (Acyclovir ( Herpes 1 2 severe genital herpes chicken pox cold sores + , , , Caution Teratogenic renal disease : , NIV vertigo ,rash, nephrotoxicity , - Nonnucleoside Reverse Transcriptase Inhibitor (Nevirapine) HIV treatment N/V , liver dysfunc , chills , fever - Nucleoside ReverseTranscriptase Inhibitor (Zidovudine) Symptomatic HIV Caution Renal dysfunc: N/V , BMS , insomnia fever , - Protease Inhibitors (Fosamprenavir) Symptomatic HIV Caution Hepatic dysfunc : Mood changes , N/V , SJS redistribution of , body fat - Fusion Inhibitor (Enfuvirtide) HIV treatmentr/f immunological detirioration Caution : Lung disease, teratogenic N/V , anorexia , pneumonia , chills - CCR5 Coreceptor (Maraviroc) CCR5-tropic HIV - evidence of replication Caution : Liver disease , hep. B , CV disease Paresthesia, hepatotoxicity, upper respiratory infection musculoskeletal , Symptoms , fever - Integrase Strand Transfer Inhibitor (Raltegravir) Resistant HIV Rhabdomyolosis , SJS , N/V , fever  Anti-hepB agent (Adefovir ( - Chronic HBV Caution Renal/ hepatic disease : Hepatomegaly nephrotoxicity , , lactic acidosis , weakness Antifungals - Azoles (Fluconazole) Oropharyngeal esophageal , , vaginal candidas , cryptococcal meningitis systemic fungal , infections Caution : / Liver renal disease Headache , N/V , abdominal pain , rash - Topical Antifungal (Clotrimazole) Oral candidas, vulvovaginal candidas athlete's foot , Stinging burning Birritation , , in sexual partner * Cream spray , , lollipop forms avalible Antiprotozoal - Antimalarial (Chloroquine Treatment/prophylaxis of malaria Caution Renal/ hepatic impairment eye : , issues Visual/auditory disturbances , hypotension , N/V  - Other (Metronidazole) Intestinal parasite trichomoniasis , Caution : Teratogenic , compromised CNS , hepatic disease N/V , metallic taste atazia seizures darkened , , , urine Charmless Antihelmintics - Antihelminitic (Mebendazole) Whipworm pinworm , , roundwor hookworm , Caution Teratogenic, hepaticdisease : Abdominal pain , diarrhea Fever ,  Pharm Exam 2 Diuretics - Thiazide/Thiazide like (Hydrochlorothiazide) - Osmotic Diuretics (Mannitol) * First line hypertension treatment Pulls H20 into renal tubule Hypovolemia ,venal disease , Gl upset, Prevent/treat renal failure , fintracranial pressure hypotension , orthostatic hypotension Dry mouth , thirst , hypotension - Loop diuretics (Furosemide Rapide extensive diuresis & failure , , - Potassium Sparing (Spironolactone pulmonary edema Patients of risk for hypokalemia , in combo Gout hypokalemia, alkalosis hypokalcemia , wother drugs for edema , improve survival , , Vertigo, for HF Caution : hyperkalemia - Carbonic Anhydrase Inhibitors (Acetazolamide) Deepening voice , gynecomastia, irregular In combo wother diuretics , glaucoma period Caution : Pregnancy , renal/hepatic failure, COPD , respiratory acidosis Metabolic acidosis bone , marrow supression, hypokalemia , tinnitus  Urinary - UTI Anti-infective (Fostomycin) Uncomplicated UTI Vaginitis , dizziness - Anti-Spasmodics (Oxybutin) Neurogenic bladder, over active bladder Blurred vision , urinary hesitancy dry , mouth , I sweating - Urinary Analgesic Pain relief for UTI Red/orange urine , Gl upset - Bladder Protectant (Pentosan Polysulfate Sodium) Bladder pain w/cystitis (Kidney infection) Bleeding, alopecia Gl upset , - Benign-Prostatic Hyperplasia (Doxazosin) Treat BPH Sexual dysfunc palpatations, Vertigo , - Finasteride  Eyes - Prostaglandin Analogs (Lantanaprost) ↓ IOP by ↑ aqueous humor outflow = Glaucoma treatment Harmless brown pigmentation - Beta-Adrengenic Blockers (Timolo) Open angle glaucoma Minamal adverse effects - Alpha Adrenergic Agonists (Apraclonidine a Brimonide) Apra : short term glaucoma treatment ↳ ; Brim : long-term decrease IOP by aqueous humor production Minimal side effects - Cholenergic Agonists (Pilocarpine) Emergency treatment for angle closure glaucoma Retinal detatchment, I visual acuity Cycloplegics Mydriatics - - Paralyze + dialate eye muscles Blurred vision, photophobia  Upper Respiratory - Antitussives (Dextromethorphan) Reduce cough symptoms - Caution :pregnant head injury Pts that , , need to cough to clear airway CNS (no driving!)) respiratory depression , Take w/water ! - Topical Nasal Decongestant (Tetrahydrozoline) Relieve uncomfortable nasal congestion Caution : Leisons in mouth /nose , pregnancy Local stinging/burning (will go away) , rebound congestion (don't take for more than 3 days! ) , disorientation (fall risk ! ) - Oral Decongestants (Pseudophedrine/Phenylephrine Nasal congestion relief + otitis media relief Caution : Polypharmacy (kids) Seizures, hypertension arrthymmias urinary , retention , used to make meth ! - Steroid Nasal Decongestant (Fluisolide) Rhinitis or pain relief following nasal polyp removal Caution : Active infection pregnancy , Local burning/stinging (will go away) ↑ risk of infection (monitor) ! , - Antihistamines Diphenhydramine Allergies allergic rhinitis prophylactic for blood , , transfusions Caution : renal/hepatic impairment Drowsiness (take@ night) Opposite drug reaction possible! - Expectorants (Guaifenesin) ↑ Respiratory Fluid output (NOT for unproductive cough) Caution : Persistant cough GI upset - Mucolytics (Acetylcysteine) Liquify/clear secretions Caution : Asthma (can cause bronchospasms) COPD , Stomatitis bronchospasm , Lower Respiratory Bronchodilators - Xanthines (Theophylline) Relieve/prevent asthma COPD bronchospasm , , Caution : pts with Gl issues , respiratory dysfunction renal/hepatic , disease, alcoholism, hyperthyroidism Smokers have I risk for toxicity palpatations arrythmmias , , Question an order for pt w/tachycardia !  Sympathomimetics (Albuterol) - Rescue drug for asthma + COPD - works quick! Restless/jittery , paradoxical bronchospasm (spasms when discontinued) - respiratory arrest - Anticholenergics(/pratropium) Maintainence of bronchospasms w/ COPD (relaxes smooth muscle) Caution : Can develop a tolerance if on it too long Palpatations , paradoxical bronchospasm urinary , retention monitor output) - Inhaled Steroids (Budesonide ↓ Swelling = prevents treat asthma (not rescuea Caution : Can worsen an infection Irritability, local infection - Leukotriene Receptor Antagonists (Zafirlukast) Prophylactic/long-term asthma treatment Caution : alcoholics , interferes w/ warfarina theophylline aspirin Upper respiratory infection pharyngitis elevated , , liver enzymes s suicidal ideation ↓ ↓ ↓ monitor WBC , temp. monitor for monitor BUN - redness irritation AST-ALT - Immune Modulators (Omalizumab) Severe asthma treatment Caution : Not for acute asthma , not for children under 6 Upper respiratory infection , ana phylaxis Lung Surfactant (Beractant) - Treatment for preemies at risk for RDS Bradycardia , hypotension pneumothorax sepsis , ,  Gastric Motility don't * you t - Chemical Stimulants (Senna Bisacodyl) , * Dulcolax have ! Short-termConstipation treatment everyday poop Caution : CAD , &block , N/V Palpatations , Cathartic dependance , CNS (older adulte fall riskl)) Bulk-forming laxatives (Psyllium) - Constipation ? start w/lubricant Treat constipation (pulls Hzoin) VIBS-P , Caution : Do not take w/antacid! Careful of hypovolemia w/HF pts bulk-form. then Gl upset CNS (older adults) , palpatations fainting perional irritation J , , LOTS of water ! 802 wand 802 after 64 02 per day - Osmotic Laxatives (Mag Citrate). Pulls HO in > - treat constipation Caution : Do not take if pt had abdominal surgery. Dehydration , CNS , palpatations , cathartic dependance - Lubricants (Docusate) Patients that shouldn't strain Cramps Oil leakage/staining , Opioid Antagonists (Methylnaltrexone Bromide - Opioid induced constipation GI upset muscle spasms not flash , ,  - GI Stimulant (Metoclopromide) GERD antiemetic , Gl movement , Caution : Do not take while on antipsycotics N/V , tardive dyskinesia , Parkinson-like symptoms - Antidiarrheals (Loperamide) Slow GI tract down , Villeostang discharge Distention, toxic megacolon , - IBS-D drug (Alosetron) Severe IBS-D treatment Ischemic colitis Gastric Enzymes - Histamine Antagonists (Cimetidine) Short term for ulcers + GERD CNS (fall risk older adults) , arrythmias , Cardiac arrest gynecomastia , impotence - Antacids (Sodium Bicarb.) Upset stomach d/ + acid , prophylactic for G) bleeding ulcers + Caution : Post op pts. Gastric rupture systemic, alkalosis hypokalemia acid rebound , , - Proton-pump Inhibitors (Protonix Omeprazole) + Short term active ulcer , burn , GERD C-Diff upper respiratoryinfection symptoms bone loss hypertension , , , - GI protectant (Sucralfate) Treatment/maintainence ulcers Caution Don't take wantacid : nothing to eat/drink 30 min after , 6) upset , sleeplessness dizziness , - Prostaglandins (Misoprostol) Prevent NSAID ulcers , off-label abortion N/V miscarrige , - Digestive Enzymes (Pancrelipase) Replace deficient pancreatic secretions N/V , proteinuria (risk for Kidney stones) Antiemetics - Phenothiazines (Prochlorperazine) Severe NV Pink/brown urine , extrapyramidal fever , neuroleptic , malignant syndrome - Non phenothiazines (Metoclopramide) GERD prevent N/V with chemo or post op , Extrapyramidal parkinson-like symptoms , , seizures  - 5 HT3 Receptor Blocker (Ondansetron) First line for N/ Prolonged &T interval , Urinary retention , Gl upset, * seratonin syndrome - Neurokinin Receptor Antagonist (Aprepitant) In combo wother drugs to prevent NJV w/chemo ↑ liver enzymes - Misc · Dexamethasone : antiemetic (unknown why) , steroid · Dronabino: Marijuana based treat , N/V ↑ , appetite · scopolmine : anticholinergic , transdermal paten (behind ear)  Pharm Exam 3 CARDI-C Heart Failure - Cardiac glycosides (Digoxin) Treats & failure - AFib dysrhythmia mental > death stupor seizures - , , Taper down ! can take a while to work  - MAOI (Phenelzine) Depression that doesn't respond to other antidepressants (not first line) Caution : Boxed warning-suicidal ideation bipolar , , contraindicated wf lots of meds Tachycardia dysrrhythmia, thostatic hypotension, headache ,nausea, mania , hypertension , Or Interacts w/tyramine foods! aged cheese, fermented food alcohol, soy , curred meats, chocolate coffee hypertensive - , sauce , Crisis - SSRI (Fluoxetine) Venlataxine ? Depression , OCD anxiety panic disorder , , Caution : Can take up to 4 weeks to work! Gl bleed hyponatremia, insomnia , sexual dysfunc , Seratonin , syndrome neuroleptic malignant syndrome ** withdrawl ! (taper ) Medication Holiday * Seratonin Syndrome - Confusion, agitation , NIV diaphoresis , , disorientation ** Neuroleptic Malignant Syndrome high fever slowed reflexes, ridgidity ↑HR - Seizures C , , , SNRI Duloxetine) - Major depressive disorderr anxiety, chronic pain Caution : Suicidal, bipolar , pregnant pts. Serotonin Syndrome , NMS , hypertension , N/ - Other (Bupropion Depression smoking cessation , Caution : Suicidal ideation Suicidal thoughts, arrythmias NIV , , tachychypo , erectile dysfunc  Anti-Psycotics - Typical Antipsycotic (Haloperidol) * Haldol Schizophrenia Caution : Dementia pt., older adults , Parkinson's Agitation extrapyramidal N/V , , , or tho hypotension , prolonged QT , NMS - Atypical Antipsycotics (Clozapine) Schizophrenia (unresponsive to typical Caution : Boxed warning neutropenia - myocarditis /cardiomyopathy Leukopenia, neutropenial seizures , ortho hypotension bradycardia , , cardiac arrest , hyperglycemia , NMS * Less side effects than typical - Bipolar (Lithium) Bipolar manic episodes+ management All related to Serum level (1 5 less) CNS polyuria , G). or = , toxicity (1 5-2) Above ECG changes (2-2 5). = +. = more CNS CV , , dilute unine (2 5e above) Multiorgan toxicity, death. = risk - ADHD -Narcolepsy (Methylphenidate) Narcolepsy+ ADHD Caution : Stimulant = addictive Hypersensitivity , Seizures , bradycardia , arrythmmia , MI , leukopenia, thrombocytopenia, anemia , insomnia & Everything goes fast  Anti-Seizure Hydantoins (Phenytoin) - Tonic-clonic Seizures , epilepsy prevention , Caution : Liver toxicity , sinus brady AV block , CNS , leukopenia , thrombocytopenia , brady , cardiac arrest , liver failure, dermatitis swollen nodes , over grown gums , , nystagmus Not used as much d/t side effects - Benzos + Barbituates Long term Seizure treatment Same as above , peds-hyper/irritable , adults = zonked out Addictive - Succinimides (Ethosuximide Absence seizures NIV , CNS , SJS , irritability - Other (Valproic Acid) Myoclonic Seizures, absence seizures focal seizures , Caution : Hepatotoxic! DRESS Crash fewer swollen nodes , , , organ failure) , CNS birth defects , a Check cmp! can happen 2-6 weeks after starting - Other (Carbamazepine) Generalized focal seizures + Caution : Boxed warning dermatological - reactions Staggering gate , hystagmus double vision , pancytopenia ,  Carbidope/Levidope - NO By or protein Anti-Parkinsonism ↓ Levidopa everyday (Carbidopa-Levidopa) me Dopaminergics take - Parkinsons relief about ask pt. ! diet TD , Ortho hypotension tachycardia , , hallucinations /night terrors /Psycosis, Vitamins malignant melanoma, red/brown /black wrine/Sweat , Levidopa= severe nausea * Given together Y effectiveness - Carbidopa prevents levidopa breakdown = - Entacopone : Given w/C L helps levidopa last longer + , = lower dose levidopa taken if Parkinson's is > - getting worse - Anticholenergic (Benztropine) mission ↓ neuve Added to drug therapy, Y Extra pyramidal symptoms Sedation, dry mouth, urinary hesitancy disorientation , constipation , USC S Muscle Relaxants - Centrally Acting (Baclofen) Musculoskeletal acute pain conditions - spinal cord injury Caution : Boxed Warning - Do not discontinue abruptly - high fever, altered mental muscle , ridgidity a rhabdomyolysis epilepsy Cardiac dysfunc. , , Seizures , coma , CNS depression hypotension , , N/V , death , sleep disturbances urinary frequency , Assess RR: ↓ reflexes , off label for alcohol withdrawl Alert? Oriented?  - Direct acting (Dantrolene) Spasticity r/ + peripheral muscles , management, neuromuscular disease (MS) Caution Interacts w/opioids liver damage (high dose) female pt : ,. over 35 , Seizures , CNS depression, Gl upset hepatitis anaphylaxis , aplastic , , anemia , HF Assess liver enzymes NMJ Blocking Agents Depolarizing NMS blocker (Succinylcholine) - Paralytic - Intubation, surgery Caution : Malignant hyperthermia,NOT for pediatric use Hypotension , skin breakdown , rhabdomyolysis malignant hyperthermia , , broncho constriction  P Opioids - Opioids Agonist (Morphine Moderate to severe pain s end of life Caution : Respiratory dysfunc recent G surgery alcohol abuse , , , head injury pregnancy addiction, neonatal , , withdrawl syndrome , benzos/barbs, diphenhydramine (drugs that cause respiratory depression) Respiratory depression , or tho hypotension , Gl upset , neurologic effects, overdose constipation NIV , , Assess RR! and HR/BP ! (Naloxone) * - Opioid Antagonists Narcan Emergency reversal opioid induced respiratory depression alcohol dependance , Caution : Pregnancy CNS excitement Acute , Opioid abstinence syndrome ↑ Pul Anti-Migraine - Ergot Derivatives[Ergotamine Contraindicated ! Prevention/treatment of vascular headache CAD ↓ BF periphery anaphylaxis ↓HR - , , , Chest pain - HTN M1 Triptans (Sumatriptan) history - - Acute migrane treatment , cluster headache * NOT prevention Caution : Pregnancy , CAD , older adults , renal/hepatic CNS G1 , CV ( , palpatations Older drug  US & General Local Anasthetics + - Nonbarbituate General Anasthetic (Midazolam) Preop sedation general anesthetiq I CU intubation , , Caution Respiratory distress : - arrest CNS depression respiratory , depression - NB General Anasthetic (Propofol) Short procedure sedation localized & injection site burning , bradycardia hypotension pulmonary , , edema - Anasthetic Gas (Nitrous Oxide Rapid potent anasthetic s dental surgery Caution : Hypoxia Sinus/middle ear pain , bowel obstruction , pneumothorax Highly flammable Antianxiety > - analgesic > - Sedate -> paralyze (succino choline * Atomodate (  Antihypercalcemic Bisphosphonates (Alendronate - Prevention of Osteoporosis Caution : Contraindicated w/hypocalcemia GI upset abdominal pain bone pain esophageal , , , erosion BLOOD GLUCOSE contraindicated Insulin A Insulinhypokalemia ! - Rapid acting (Lispro) + aspart BolusInsulin : Short/rapid before meals before bed , · Right before a meal Basal Insulin (Backround) : · "Bolus Insulin" Intermediate/long acting between meals - Onset : 15-30 min overnight Peak : 0 5-3hr. (most likely to get hypoglycemic Basal-Bolus : Rapid & meals Duration : 3-5hr long acting 1-2 times a day Hypoglycemia hypokalemia, , nausea headache , - Short acting (Regular). 30-60 min before meal , IV push for DKA , hyperkalemia N Onset : 30 min-Ihr : insulin IV push Peak : 1-5hr (2-4hr) severe hypo Kalemia! Duration : 6-10hr ↓ ! check potassium Hypokalemia hyperglycemia anaphylaxis , , replace potassium insulin before giving o time IV bolus of regular insulin same DKA = push insulin before IV drip ! as lines) (separate  be mixed ! * Regular NPH can ↳ draw regular up first ! intermediate (clear before cloudy) rapid before - Intermediate acting (NPH) · Half day / overnight coverage ! Onset : 1-2hr * Glucagon Peak : 4-14hr Duration : 14-24hr m Hypoglycemia hypokalemia unconcious , ↓ - Long acting (Glargine/Detemir) DSolv S Geng Full day coverage · Onset : 1-4 hr * Peak : None spiking Duration : 24hr  Oral Antidiabetics increases ediction - Sulfonylureas (Glyburide) production insulin glyburide Combo w/diet to manage Type II DM Combo , w/metformin insulin No Caution : DKA no = Gl upset , anorexia heartburn , , hypoglycemia skin reactions , - Biguanide (Metformin) Combo w/diet- exercise for Type II DM * hold 48 hr ↑N fluids Caution : DO NOT GIVE CONTRAST To Pt. (MRI CT) ,. Hypoglycemia , lactic acidosis GI upset , * Type 11 diabetics need insulin too ! * I unit = ImL  NDOCRINE Pituitary - Posterior Pituitary (Desmopressin) Diabetes Insipidus , von Willibrand , hemophilia Caution : Hyponatremia risk Fluid retention dry mouth , flushing nausea , , Adrenal Cortical Agents - Glucocorticoid (Prednisone) Adrenal cortical insufficiency inflammatory disorders hypercalcemia / + , , cancer , hematological disease ulcerative colitis , , Ms , COP Caution : Infection risk ! Vertigo , hypotension , shock , fluid/sodium retention weight gain , , delenium Thyroid+ Parathyroid Agents - Thyroid Horomones (Levothyroxine) Replacement therapy r/ hypothyroidism pituitary TSH , suppression / thyroid cancer Tremors N/V tachycardig HF arrythmmia , hyperthyroidism * , , , , Antithyroid Agents - Thiomides (Methimazole ↓ Thyroid horomone levelsr/t hyperthyroidism N/V , liver toxicity , nephritis , bone marrow supression, Vertigo  Parathyroid Agents - Antihypocalcemics (Calcitrol) Hypocalcemic management r/t dialysis e hypo parathyroidism Metallic taste , N/V muscle/bone pain , REPRO Female Repro Agents - Estrogens (Estradio) Menopause symptoms , prevent post-menopausal osteoporosis, remempogonadismovarian failure,inoperablebreastprostate cana one Corneal changes changes , in menstural cycle , cholasma stroke , - Progestins (Norethindone Acetate) Amenorrhea abnormal , uterine bleeding , endometriosis , Some horomonal BC's Caution : Epilepsy, migraines , asthma , CV/ renal dysfun Vision loss. ↑ weight , venous thromboembolism , ache , migraines - Estrogen Receptor Modulators (Raloxifene Prevent/treat postmenopausal Osteoporosis, Brest Cancer risk Caution : Pt that. have history of venous thrombosis or smoking Venous thromboembolism not flashes Vaginal , , bleeding pulmonary embolism ,  Fertility Drugs Clomiphene - Ovarian failure off label for , male sterility Caution : Thromboembolic disease , respiratory disease Vasomotor flushing multiple , births , NIV. breast tenderness, Ovarian enlargement - Oxytocin Initiate/improve uterine contractions (induce labor) , second trimester abortion Control PP , bleeding Caution : Mothers that had previous C-section Water intoxication arrythmia uterine rupture , HTW , , , fetal bradycardia - Tocolytics (Hydroxyprogester one caprote) ↓ Preterm birth risk Glucose intolerance , fluid retention breast , cancer , liver disease Male Repro Agents Androgens (Testosterone) - Replacement for hypogonadism delayed puberty, , Caution : Liver func., CV disease Sleep disorders, androgenic effects , hepatitis , hypoestrogenic effects - Erectile Dysfunction (Sildenafil ED , pulmonary arterial HIN Caution : Bleeding disorders , nitroglycerin VTI headache , , hearing loss , hypotension