Pathogenesis of Common Childhood Viral Diseases PDF

**[Pathogenesis of common childhood viral diseases - 2.3 ]** Viral taxonomy - - - - -  From 2021, viruses need binomial nomenclature **Baltimore classification** I. II. III. IV. V. VI. VII. Virus = broader term, infectious entity in all its stages, taxonomic...

**[Pathogenesis of common childhood viral diseases - 2.3 ]** Viral taxonomy - - - - -  From 2021, viruses need binomial nomenclature **Baltimore classification** I. II. III. IV. V. VI. VII. Virus = broader term, infectious entity in all its stages, taxonomic classification Virion = most complex and complete physical manifestation, viral genome + capsid + envelope, extracellular infective form, transmitted Pleomorphism - - - - Characteristics - - - Structure  Life cycle - - If no host: - - - - Pathogenesis Implantation → local replication → spread to target organs → shedding to environment Entering the host - - - - - - - - - - Cellular response to viral infection - - - - **Innate Immunity** **Adaptive Immunity** --------------------- ----------------------- Complement Antibodies Interferons T cells NK cells Immunological memory APOBEC3 proteins Tetherin RNA silencing Apoptosis Outcome of viral disease in host - - - - - - - - - - Spores and prions cannot be killed Mouthwash may deactivate viruses but not enough evidence **[Childhood viral diseases ]** HPV - viral warts - Human Papillomavirus - - - - - - - - - - - - Common cold - Rhinovirus - - - - - - - Paramyxoviridae = consists of 3 genera: 1. 2. 3. Adenoviruses = common viruses that cause cold symptoms, fever, sore throat, bronchitis, pneumonia, diarrhea, conjunctivitis Orthomyxoviruses = included influenza viruses divided into types A, B, C  Influenza - Orthomyxovirus type A, B, C - - - - Human seasonal influenza virus Types A and B undergo genetic variation - basis for emergence of new strains, type C is antigenically stable Genomic reassortment  Cold and flu - SARS-CoV-2 - - - - - Oral symptoms - - - - - - - - - -  Hand foot and mouth - Picornavirus family of viruses eg: Coxsackie group A virus - - Measles - Paramyxovirus of genus Morbillivirus - - Mumps - Paramyxovirus of genus Rubulavirus - - Rubella / German measles - caused by only member of genus Rubivirus or the family Togaviridae - - Chicken pox - Herpes Zoster (Varicella) - -