Endocrine Disorders PDF

Endocrine Disorders Dr Nithya Sukumar Associate Clinical Professor, Warwick Medical School Consultant Physician in Diabetes and Endocrinology, George Eliot Hospital NHS Trust August 2024 n.sukumar@warwick...

Endocrine Disorders Dr Nithya Sukumar Associate Clinical Professor, Warwick Medical School Consultant Physician in Diabetes and Endocrinology, George Eliot Hospital NHS Trust August 2024 [email protected] Learning outcomes To revise the hormones synthesised by pituitary gland and their downstream effectors To understand the endocrine causes and management of unintentional weight loss To understand the endocrine causes and management of unintentional weight gain To gain an overview into the pathophysiology and pharmacotherapy of obesity Learning outcomes To revise the hormones synthesised by pituitary gland and their downstream effectors To understand the endocrine causes and management of unintentional weight loss To understand the endocrine causes and management of unintentional weight gain To gain an overview into the pathophysiology and pharmacotherapy of obesity Overview of pituitary hormones and downstream targets Learning outcomes To revise the hormones synthesised by pituitary gland and their downstream effectors To understand the endocrine causes and management of unintentional weight loss To understand the endocrine causes and management of unintentional weight gain To gain an overview into the pathophysiology and pharmacotherapy of obesity Case 1: History A 62-year-old female is evaluated in the emergency department for severe abdominal pain and recent weight loss (9kg in last 3 months) Also history of anxiety, frequent palpitations, difficulty concentrating, dyspnoea and diarrhoea An abdominal CT scan obtained several weeks ago when she first experienced abdominal pain was normal Case 1: Examination Anxious and agitated Observations: temperature 36.9 °C, BP 160/90 mm Hg, pulse rate is 130/min and regular, respiratory rate is 22/min. Skin warm and moist Cardiac examination shows a grade 2/6 holosystolic murmur, crackles heard on lung examination. Abdominal examination reveals a palpable liver 2 cm below the right costal margin. Differential diagnosis?? Causes of unintentional weight loss Malignan GI Psychiatri Endocrine Infectious Neurolog Advanced Chronic Medicatio cy disorders c diseases y chronic vigorous ns / disease exercise substanc es GI Peptic Depressio Hyperthyr HIV Stroke End- Distance Alcohol ulcer n -oidism stage running disease heart failure Lung Celiac Eating Adrenal Viral Parkinson COPD Ballet Cocaine disorders insufficie- hepatitis ’s dancing ncy Lymphom IBD Diabetes TB Renal Gymnasti Ampheta- a (uncontro failure cs mines l-led) Prostate Chronic Prescribe helminthi d drugs c for DM / infections hypothyr o-idism / Case 1: Investigations Bedside: ECG shows NSR 144bpm, BM 5.9 Bloods: Result Normal range Thyroid stimulating