OTC Drugs (CEE 1) PDF

CEE 1 OTC Drugs  ___________ A Drug - an agent intended for use in diagnosis, mitigation, cure, treatment, or prophylaxis Affects the structure or any function of the body cosmetic is applied in external or mucus membrane  RA 10918 (Philippine Pharmacy Law)...

CEE 1 OTC Drugs  ___________ A Drug - an agent intended for use in diagnosis, mitigation, cure, treatment, or prophylaxis Affects the structure or any function of the body cosmetic is applied in external or mucus membrane  RA 10918 (Philippine Pharmacy Law) 2016 ____________________ Prescription drugs refer to medicines which can only be dispensed by a pharmacist to a patient, upon the presentation of a valid prescription. ____________________ refer to medicines used for Over the Counter Drug symptomatic relief of minor ailments and which may be dispensed without a prescription.  presrbers info Prescription patient info ________________________ date a written order and instruction for use prescription of specific drug for specific patient inscription medication subcription prescription instruction physician sig. and info. Summary RX DRUGS OTC DRUGS Prescribed by a Doctor drugs that do not require a doctors preciption Bought at a pharmacy Also available in pharmacy outlets Prescribed for and intended to be used regulated by FDA through OTC by one person drugs monograph Regulated by FDA through the New Drug Application (NDA) process  Brand Ø____________________ refers to the proprietary name given by the manufacturer to distinguish its product from those of competitors Ø____________________ Generic refers to the scientifically and internationally recognized name of the active ingredients, as approved by the FDA “Generic act of 1988”  normal temp 37+- 0.5 degrees C used for pain management reduces fever A. Analgesic, Anti-inflammatory, and Antipyretic Drugs reduces inflammation in the body  greater effect anti pyretic 1. Paracetamol, BP and analgesic MOA: weak COX inhibitor /blocks COX What is the advantage of Paracetamol? ü safe to use by the special populations Pregnant/children no anti-inflammatory effect Toxic effects: Hepatotoxicity NAPQI(toxic metabolites) N-acetyl-p-benzoquinone-imine - high accumulation of _____________________ Treatment: N-acetylcysteine Risk factors: 150mg/kg/day pre-existing liver disease N greater than 4g/day Biogesic tablets 500mg Oral suspension: 120mg/5mg, 250/5mg Biogesic for kids Oral Drops: 100mg/ml Oral suspension: 120mg/5mg, 250/5mg calpol Oral Drops: 100mg/ml Tab: 325 mg tempra Forte Tab: 500 mg Syrup: 120mg/5mg, 250/5mg Oral Drops: 100mg/ml kiddilets Chewable Tablet: 120mg  lol im not going to faillllll Alaxan FR CAP PARACETAMOL 325mg, Ibuprofen 200mg Phenylephrine 10 mg, Chlorphenamine 2mg, PARACETAMOL 500MG Bioflu tab HNBB 10mg, PARACETAMOL 500mg Buscopan Venus Dolo neurobion PARACETAMOL 500mg, Vit. B1 50mg, Vit. B6 100mg, Vit. B12 100mcg Decolgen Forte tab: PARACETAMOL 500mg, PPA 25mg, Chlorphenamine 2mg Per Forte capsule: Chlorphenamine 1mg, Dextromethorphan 10mg, PPA 12.5mg, mucotuss PARACETAMOL 325mg  per Forte tab: Phenylephrine 10 mg, Chlorphenamine 2mg, Neozep PARACETAMOL 500mg Per Non-Drowsy tab: Phenylephrine 10mg, PARACETAMOL 500 mg Nasatapp No-DrowseTab: Paracetamol 500mg, Phenylephrine 25mg Rexidolforte Tab: PARACETAMOL 500mg, Caffeine 65mg (enchance analgesic effect of Tab: PARACETAMOL 250mg, Prophynazonepara150mg, Caffeine 50mg Seridon Tab: PPA 25mg, Chlorphenamine 2mg, PARACETAMOL 325mg symdex-D Forte tab: PPA 25mg, Chlorphenamine 2mg, PARACETAMOL 500mg Cap: PARACETAMOL 325mg, Dextro 15mg, Phenylpropanolamine 35mg tuseran 2. Non-steroidal anti-inflammatory agents (NSAIDS) MOA: COX inhibition (housekeeping/maintenance) /cytoprotection (Triggered/response to stimuli like physical injury)  Non-selective NSAIDS a. ASPIRIN - ___________ prototype NSAID (Dose dependent) Analgesic: 600mg/day Anti-inflammatory: 3.2-4g/day Antipyretic: 0.3-1.2g/day Antiplatelet: NMT 325 mg/day  Arthritis not given to GOUT patients §Hyperuricemia §Aspirin toxicity - Reye’s syndrome (hepatic failure) §GI effects §Low urine output - all NSAIDs (reversible) §NSAID-induced Bronchial Asthma dont give aspirin to viral infection like chicken pox  fenamates Non-selective NSAIDS Mefenamic Acid -analgesic only 250mg tablet/capsule, 500 ponstan mg capsule/tablet, 50mg/5ml suspension pontein 500mg tab dolfenal 250 mg tab, 500 mg tab Gardan 500mg tab 250mg is OTC 500mg is Rx not ideal for children  Non-selective NSAIDS Ibuprofen safest for children 200 mg soft gel capsule Advil, medicol 400 mg Medicol 100 mg/5ml suspension Dolan FP, Advill suspension for kids 200 mg/5ml suspension Dolan FP Forte Ibuprofen (3 uses) Indications: üFor the relief of mild to moderate aches and pains üFor the relief of other types of pain such as earache üFor fever reduction Non-selective NSAIDS Naproxen flanax 275mg, 550mg sarimax 275mg, 550mg skelan 220mg, 550mg green is OTC Red is Rx  Non-selective NSAIDS Diclofenac (______) Cataflam 25 mg Tablet - preferably taken before meals. swallow as Other OTC Preparations: a whole, do not chew/divide Local symptomatic relief of 14 years old and above: pain and inflammation Spray to affected site tid- Acuflam spray (10mg/g) qid (at least 4 hours interval) Relief of pain, inflammation, Apply tid-qid Voltaren Emulgel (1%) and swelling B. Antihistamines a. 1st Generation Antihistamines § Meclizine § Chlorpheniramine, Brompheniramine ____________ Meclizine (Board exam drug) § Anti-emetic § For motion sickness, nausea, and vomiting § Taken ______ 1 hour before travel BD Bonamine Dizitab § ______________ Bonamine § 12.5 mg Chewable tablet § 25 mg Chewable tablet § ________________ Dizitab § 25 mg Chewable tablet  Phenylephrine 10 mg, Chlorphenamine 2mg, Paracetamol 500mg Bioflu per 5ml syrup: Phenylephrine 2.5mg, Chlorphenamine 0.5mg, Paracetamol Neozep 125mg per ml oral drops: Phenylephrine 1mg, Chlorphenamine 0.8mg Per ml syrup: Phenylephrine 5mg, Chlorphenamine 1mg Disudrin per ml drops: Phenylephrine 2.5 mg, Chlorphenamine 0.5mg Nasatapp PPA, Brompheniramine H1 Blockers b. 2nd Generation Antihistamines §Cetirizine piperazine §Loratadinepiperidine  less sedating Cetirizine - Brand name and formulation available in the market Allerkid Syrup (5mg/5ml), Oral Drops symptomatic relief of allergic conditions (2.5mg/5ml) including rhinits and urticaria 10 mg tablet symptomatic relief of allergic rhinitis and Alnix Tablets skin symptoms of allergy like itch and rash FC tab 10 mg, oral sol’n relief of nasal and ocular symptoms of 1mg/ml, Oral drops 10mg/ml seasonal allergic rhinitis Virlix  non sedating Loratadine Brand name and formualtion available 10mg tab, 5mg/5ml syrup 12 years old and above: 1 tab Allerta tab 2-12 years old: >30kg - 1 tab, 10 years old: 1-2 tab daily at night 4-10 years old: 1 tab daily at night dulcolax Ped supp: 5mg Adult supp: 10mg >10 years old: 1 adult supp daily 4-10 years old: 1 ped supp daily