Osteoarthritis lecture 2024 (1).pdf

PHM 101: General Medicine Osteoarthritis (OA) Mar 8 2024 Amita Woods PharmD Pharmacy Clinical Manager UHN Acknowledgement: Sameera Toenjes  Osteoarthritis Learning Objectives To understand the pathophysiology of osteoarthritis for the purposes of - Identifyin...

PHM 101: General Medicine Osteoarthritis (OA) Mar 8 2024 Amita Woods PharmD Pharmacy Clinical Manager UHN Acknowledgement: Sameera Toenjes  Osteoarthritis Learning Objectives To understand the pathophysiology of osteoarthritis for the purposes of - Identifying drug therapy problems Assessing therapeutic alternatives in different patients – Developing a care plan – Goals/ endpoints of therapy – Providing patient education Detailed discussion of drug therapy will happen in workshops  What is Osteo “arth” r ”itis”? The most common form of arthritis A disease of diarthrodial joints Involves the entire joint; articular cartilage, synovium, capsule, subchondral bone  Epidemiology One of the leading causes of disability and loss of productivity (and on the rise) Effects 1/10 Canadian adults Prevalence increases with age, with 65% of those over age 80 affected Prevalence varies with – gender (Cdn data 11.6 (men) vs 16.7(women)/ 1000) – genetics – ethnicity (hip OA white> indian, asian or black What is the most preventable risk factor?  A 1 kg increase in weight increases your risk of developing osteoarthritis by ___%  Risk Factors Obesity Advancing age – symptomatic knee OA 4.9% for all>25yo vs 12.1% for those over 60yo Female vs men – Hip, knee & hand OA more prevalent in women >50yo – Men