NPB010 Lecture 21 PDF

* NPBolo Lecture 21 "li8 (we discussed granilocytes) 2 group : macrophages -w big...

* NPBolo Lecture 21 "li8 (we discussed granilocytes) 2 group : macrophages -w big eat other cells like · neutrophilic granulocytes > - they phagocytose · Help clean up old/dead cells (Red blood cells) Materia · virus. , Le present small fragments of bacterial viruses on MHC proteins > - talk to T cells but then settle in Initially mobile , a small area of your body  ② Group 3 - lymphocytes ↳ types B cells T cells ⑤&NK all natural killera all cytoplasm B cells produce antibodies H large proteins , we make these , they bind tightly (high affinity to antigens.  ③ Antibody protein of : 4 units Y / This is variable domain => where we bind pathogen. I Can look millions of different ways Constant domain Here cells of immune system will connect & destroy what is bound on variable domain Soluble protein => secreted into blood after B all is activated -  ④ How are antibodies useful 8 - I NK cells * ↑ recognize constant -- macrophages antibody domain aboknow how to bind # toxin Y / body prote I now toxin can not in bind to our protein I This is used somebad cellular to treat response tetanus.  ⑤ When we vaccinate one objective is to activate B cells have them produce antibodiess. ↳ to be fully active Balls need T cells # cells) and type of lymphocyte Can only recognize pathogen when chunks (antigen) are presented to them by cells of b ody our.  ⑥ = pa C MH macrophage ⑭ - * & Several 1) Helper ↳ · T cells , they recognize they organize the adaptive response , by sending to other immune Eytones cell 2 ↳ "Kinetics" makes Cells other cells do something HIV cause AIDS by attacking & killing chacquired immuno-deficiency O these syndrome  ⑰ 2) cytotoxic T cells these kill body cells. · cancer cells (these have mutations in several proteins) · virus-infectedalls in both cases we see "non-self" proteins on MHC of the body cells. T 3) regulatory all & end of infection , these will stop the response  ⑳ 3)Third lymphocyte : NK cells natural killer all act like inmate immune cells (macrophages & granulocytes) because antibodies to bind they rely on PAMPs-receptors m not have Innate response granulocytes] Patterncognise macrophages -tag9 NK cell 3) Cross ala Adaptive responses Bull , T cells lets build an adaptive immune response * 3 future antibody ⑮al B ceil receptor - naive ->> hasn't bound with its receptor anything To activate 1) something binds B cell receptor 2) Helper T cells sends cytokines Once active ) copy itself a lot ↳ some make antibody  ⑩ cells" "Plasma they produce a lot of antibody & die after a few day s. ↳ others become dormant, wait for second they a infection with same B pathogen "Memory celly"