Lecture 12: MHC Class I and Class II PDF
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Bluefield University
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This document provides an overview of MHC Class I and Class II, including histocompatibility antigens, functions, and loci. It emphasizes the role of the major histocompatibility complex in immune responses and cell development.
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Drive Search in Drive Page 1 of 23 New My Drive Computers My Drive Type People Modified Lecture 12: MHC Class I and Class II Suggested 1. Histocompatibility Antigens a. Expressed to identify an individual’s tissue Shared with me b. Also serves as leukocyte antigens since APCs and lymphoc...
Drive Search in Drive Page 1 of 23 New My Drive Computers My Drive Type People Modified Lecture 12: MHC Class I and Class II Suggested 1. Histocompatibility Antigens a. Expressed to identify an individual’s tissue Shared with me b. Also serves as leukocyte antigens since APCs and lymphocytes are crucial Recent c. Major histocompatibilityImmunology complex: elicit Ab responses; Academic Advising Appoin… Exam 2.pdfare major determinants for Untitled document rapid transplant rejection Starred d. Minor histocompatibility complex: don’t elicit Ab; involved in self/non-self Spam recognition, but to lesser extent than major histocompatibility complex 2. MHC Functions: Trash a. During lymphocyte development i. Part of T and B cell “education” process à allows them to see MHC Storage You opened in the past week 1.08 GB of 15 GB used Get more storage Physiology Exam 1 Learnin… peptide complexes opened in the past week b. During immuneYou response You edited yesterday You opened in the past month i. Processed Ags are inserted into MHC Class I and II molecules and presented to lymphocytes Folders Name ii. For activation: lymphocyte must see Ag on MHC to go from naïve to activated state iii. For effector function: some lymphocytes also recognize SAME Ag on the MABS MABS (2022-2023) R… SAME MHC molecule to perform its job MABS Application Research Sharepoint … 2020 Christmas List 6812.pdf 3. Loci Files a. Region of chromosome 6 where multiple clusters of MHC genes are located b. MHC Class I, II, and III 1902-308 Move-In Ch… 1902-308 Class I Class II Class III Proteins Classical: HLA-A, -B, - Move-In Ch… HLA- DP, -DQ, - DR Genes encoding C (highly stimulated) cytokine and Non-classical: HLA-E, - complement proteins F, -G (immunosuppressive) Composition - 3 alpha chain domains - One alpha chain and – alpha 1 and 2 form one beta chain (2 peptide binding groove domains each) - beta2 microglobulin - alpha1 and beta1 form (beta2 not MHC peptide binding groove protein) - anchor residues - anchor residues - a lot of peptides can fit
