Magnesium Sulfate Drug Information PDF
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Mesa Community College
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This document provides information on the drug magnesium sulfate, including its mechanisms of action, indications, dosages, and adverse reactions. It is intended for use by medical professionals.
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GENERIC NAME magnesium sulfate CLASSES Electrolyte Anti-inflammatory Tocolytic (labor suppressant) STANDARD SUPPLY Vial MECHANISMS OF ACTION Decreases ventricular irritability Decreases release of acetylcholine that inhibits muscular excitability Causes uterine relaxation Relaxes bronchial smooth mu...
GENERIC NAME magnesium sulfate CLASSES Electrolyte Anti-inflammatory Tocolytic (labor suppressant) STANDARD SUPPLY Vial MECHANISMS OF ACTION Decreases ventricular irritability Decreases release of acetylcholine that inhibits muscular excitability Causes uterine relaxation Relaxes bronchial smooth muscle resulting in bronchodilation Raises the seizure threshold in eclampsia and preeclampsia INDICATIONS Seizures caused by toxicity of pregnancy (toxemia) Pregnancy induced hypertension (pre-eclampsia and eclampsia) Pre-term labor Torsades de pointes (polymorphic ventricular tachycardia) Ventricular fibrillation and pulseless ventricular tachycardia refractory to amiodarone or lidocaine Reactive airway conditions including bronchoconstriction and bronchospasm CONTRAINDICATION Hemodynamically significant heart block ADVERSE REACTIONS/SIDE EFFECTS Central nervous system depression Drowsiness Hypotension Respiratory depression Dysrhythmias ROUTES OF ADMINISTRATION IV IO Infusion 64 ONSET OF ACTION Immediate ADULT DOSAGES Torsades de pointes infusion: 1.0 to 2.0 gm in 50 to 100 mL over 5 minutes May repeat the dosage 1.0 to 2.0 gm over 1 hour Pre-term labor/pre-eclampsia/eclampsia infusion: 3.0 to 6.0 gm in 100 mL over 10 to 20 minutes May repeat the initial dosage Maintenance infusion: 1.0 to 4.0 gm/hour Reactive airway conditions: 2.0 gm in 50 mL over 5 to 10 minutes Cardiac arrest IV/IO: 1.0 to 2.0 gm over 1 to 2 minutes PEDIATRIC DOSAGES Reactive airway conditions infusion: 25 to 50 mg/kg 10% solution infused over 15 to 30 minutes Maximum dosage 2.0 gm SPECIAL CONSIDERATIONS The peak effect of the drug is variable The duration of the drug is 1 hour An infusion pump should be used to administer the drug when possible 65
