Model Examination Paper 1 (General Pathology & Haematology) PDF

**Name:** **MODEL EXAMINATION -- PAPER -- 1** **(General Pathology and haematology)** **Time: 3 Hours Total Marks: 100** **Answer all questions.** **Draw labelled diagrams wherever necessary** **Long Essays (2x10=20marks)** 1. A 38-year-old pregnant woman with history of multiple, closely...

**Name:** **MODEL EXAMINATION -- PAPER -- 1** **(General Pathology and haematology)** **Time: 3 Hours Total Marks: 100** **Answer all questions.** **Draw labelled diagrams wherever necessary** **Long Essays (2x10=20marks)** 1. A 38-year-old pregnant woman with history of multiple, closely spaced pregnancies, develops fatigue, pallor, koilonychia, alopecia, and atrophic changes of the tongue of one-month duration (a) What is your provisional diagnosis (b) Describe the peripheral smear and Bone marrow finding (c) Describe the pathogenesis and complications of this condition **(1+4+5=10 marks)** 2. Define acute inflammation and 2 beneficial effects of acute inflammation. Discuss vascular changes and cellular events of acute inflammation What are the the outcomes of acute inflammation (2+4+4) **Short notes (6x6=36 marks)** 3. Type IV hypersensitivity 4. Paraneoplastic syndromes 5. Free radical injury 6. Chemical carcinogenesis 7. Immune Thrombocytopenia Purpura 8. necrosis **Short answers (6x4=24 marks)** 9. Rickets. 10. Tertiary Syphilis 11. Role of P53 in gene in tumor suppression 12. Aetiopathogenesis of Burkitt's lymphoma and its morphology 13. Chemotaxis 14. Differences in CSF in pyogenic and tuberculous meningitis **15. Multiple choice questions (20x1=20marks)** Case Scenario: Question numbers i-v are case scenario based questions i\. An autopsy is performed on a 65-year-old man, who died of congestive heart failure. liver reveal yellow-brown granules in the cytoplasm of most of the hepatocytes. Which of the following stains would be most useful to demonstrate with positive staining that these yellow-brown cytoplasmic granules are in fact composed of hemosiderin (iron)? (a) sudan black (b) Oil red O stain (c) Periodic acid- Schiff stain (d) Prussian blue stain ii\. A 45-year-old poor man Teja has a chronic cough, a cavitary lesion of the lung, and is sputum positive for acid-fast bacilli. Which of the following is the principle form of defense by which the patient's body fights against this infection? (a) Antibody-mediated phagocytosis (b) Cell-mediated immunity (c) IgA-mediated hypersensitivity (d) Neutrophil ingestion of bacteria 3\. A pregnant woman develops deep, boring pain of her left thigh muscles associated with swelling and enhanced warmth of the same leg. The pain is worsened by extending the foot. The superficial veins of the leg are engorged. Her condition puts her at risk for which of the following? (a) Acute renal failure (b) Cerebral hemorrhage (c) Hepatic infarction (d) Pulmonary embolism 4. A nineteen year old female with short stature, wide spread nipples and primary amenorrhea most likely has a karyotype of: (a) 47, XX + 18 (b) 46, XXY (c) 47, XXY ( d) 45 X 5. An undifferentiated malignant tumor on immunohistochemical stain shows cytoplasmic positivity of most of the tumor cells for cytokeratin. The most probable diagnosis of the tumor is: (a) Sarcoma (b) Lymphoma (c) Carcinoma (d) Malignant melanoma **Assertion-Reason type: For questions vi- x there are two statements marked as -- Assertion (A) and (R). Mark your answer as per options provided** **a) A is incorrect R is correct** **b) Both A and R are correct but R is not the reason for A** **c) A is correct, R is incorrect** **d) Both A and R are correct and R is the reason for A** vi\. Assertion: overexpression of bcl2 causes cellular proliferation Reason: bcl2 is antiapoptotic vii\. Assertion: metaplasia associated with increased risk of cancer Reason: metaplasia allows defective cells to survive viii\. Assertion: malignant tumours can metastsize Reason: malignant tumours show nuclear atypia ix\. Assertion: lepromatous leprosy dosent show granuloma. Reason: These patients have low immunity x\. Assertion: Tumour cells are dyscohesive in diffuse gastric carcinoma Reason: They are characterised by beta catenin mutation **Multiple response type questions. Read the questions and mark the answer appropriately** xi\. Correctly matched pairs in amyloidosis are: (a) Multiple myeloma - light chain (b) Chronic inflammation -- AA (c) Cardiac -- ATTR (d) Neural -- Beta-2 microglobulin xii\. Arterial thrombosis is seen in (a) Homocysteinemia (b) Anti-phospholipid syndrome (c) Protein S deficiency (d) Protein C deficiency (e) Antithrombin III deficiency xiii\. True about apoptosis (a) Migration of Leukocytes (b) End products are phagocytosed by macrophage (c) Intranuclear fragmentation of DNA (d) Activation of caspases (e) Annexin V is a marker of apoptotic cell xiv\. Which of the following is true of Klinefelter's syndrome: (a) Chromosome pattern in 47 XXY (b) Mental retardation is present (c) Hypogonadism occurs (d) Increased FSH level (e) Eunuchoid xv\. Cancer cell survival is enhanced by: (a) Suppression of p53 protein (b) Over expression of p53 gene (c) bcl-2 (d) bax **Multiple choice questions- Single response type (xvi-xx)** xviii. The most common secondary malignancy in a patient having retinoblastoma is: (a) Osteosarcoma (b) Renal cell carcinoma (c) Pineoblastoma (d) Osteoblastoma