Cerebral Physiology Lesson 6 and 7 PDF
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Summary
This document provides an overview of cerebral physiology, including cerebral blood flow and the Monroe-Kellie hypothesis. It outlines normal ranges and critical thresholds for blood flow.
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[Cerebral Blood Flow ] - **Monroe-Kellie hypothesis** = the sum of volumes of brain, CSF, and intracranial blood is constant. An increase in one should cause a decrease in one or both of the remaining two - **Cerebral blood flow** - Normal range 50mL/100g - Greater blood...
[Cerebral Blood Flow ] - **Monroe-Kellie hypothesis** = the sum of volumes of brain, CSF, and intracranial blood is constant. An increase in one should cause a decrease in one or both of the remaining two - **Cerebral blood flow** - Normal range 50mL/100g - Greater blood flow in the cortex (gray matter) vs subcortex (white matter) - Takes 15% of cardiac output - Affected by supply, perfusion, and cerebral vascular resistance - Critical thresholds for CBF - Ischemia at 20mL/100g - Cortical suppression \~15mL/100g - Cell death \
