Lecture 5_020824 PDF

 GENERAL CHARACTERISTICS OF VIRUSES Viruses contain a single type of nucleic acid (DNA or RNA) and a protein coat, sometimes enclosed by an envelope composed of lipids, proteins, and carbohydrates. They multiply by using the host cell's synthesizing machinery to cause the synthesis of spe...

 GENERAL CHARACTERISTICS OF VIRUSES Viruses contain a single type of nucleic acid (DNA or RNA) and a protein coat, sometimes enclosed by an envelope composed of lipids, proteins, and carbohydrates. They multiply by using the host cell's synthesizing machinery to cause the synthesis of specialized elements that can transfer the viral nucleic acid to other cells  Uses: Genital Herpes simplex Primary disease Recurrent disease Mucocutaneous H. simplex H. simplex encephalitis (type-1 virus) H. simplex keratitis Herpes zoster Chickenpox  Uses CMV- induced retinitis in patients with AIDS Amantadine Uses: Prophylaxis of influenza A2 during an epidemic or seasonal influenza Treatment of influenzal (A2) illness Reduction in fever, congestion, cough and quicker recovery Parkinsonism  Uses: Zidovudine is used in HIV infected patients only in combination with at least 2 other ARV drugs Used for prevention of perinatal HIV-1 infection. TENOFOVIR Is the only nucleotide analogue, relatively newer Due to good tolerability profile, it is included in first line regimens Tenofovir containing regimens have been found as effective and less toxic as other first line regimens  INTEGRASE INHIBITORS Dolutegravir Raltegravir Bictegravir Elvitegravir ANTIMICROBIAL RESISTANCE (AMR)