Biorisk Management MT-MLS 101A PDF

BATCH 2028 TRANS A.Y. 2024-2025 No. 011-092024 College of Medical Laboratory Science (CMLS) MT-MLS 101A: Principles of Medical Laboratory Science I LEC/LAB: Biorisk Management...

BATCH 2028 TRANS A.Y. 2024-2025 No. 011-092024 College of Medical Laboratory Science (CMLS) MT-MLS 101A: Principles of Medical Laboratory Science I LEC/LAB: Biorisk Management Transcribed by: Nigella B. Rivera NOTE: This trans is STRICTLY PROHIBITED from unauthorized distribution and photocopying for other purposes solely than the recipient’s personal use. A unique tracking number has been incorporated for all the batches of transes distributed by the CMLS-SC Academics Committee. Thus, should we have been notified that this trans has undergone unwarranted distribution, even beyond the 4 course of this PRELIM – FIRST SEMESTER of the A.Y. 2024-2025, the CMLS-SC Academics Committee has the right to terminate 02 this project for the said respective batch. -2 OUTLINE ○ Microorganism: Parasites, Bacteria, Fungi, & Viruses 23 I. Introduction to Biorisk Management A. Biorisk Exposure + Hazard = Risk 1. Likelihood 20 Exposure is very + Hazard = Minimal Risk 2. Consequences limited/controlled 3. Sources of Risks NO HAZARD → NO EXPOSURE → NO RISK II. Biorisk Management and the AMP model Y. A. Biorisk Management A. B. Biosafety Risk C. Biosecurity Risk LIKELIHOOD D. Why do we need BRM? E. Goal of BRM E Probability of a risk from happening TE F. Biorisk Management Strategy Level Descriptor Likelihood-Description G. AMP Model 1 Rare May occur only in exceptional 1. Assessment IT circumstances 2. Mitigation 2 Unlikely Could occur at some time 3. Performance MM III. Risk Management Key Components 3 Possible Might occur at some time A. Risk response 4 Likely Will probably occur in most B. Steps of risk assessment circumstances CO C. Risk mitigation 5 Almost Certain Is expected to occur in most D. Hierarchy of controls circumstances E. Mitigation F. Performance evaluation CONSEQUENCES S IC BIORISK Probable outcomes should risk really occur EM Level Descriptor Likelihood-Description Refers to the potential harm caused by the biological 1 Insignificant No injuries, low financial loss agent and the likelihood of such harm from happening. 2 Minor First aid treatment, on site release AD Effect of uncertainty expressed by the combination of the immediately contained consequences of an event (including changes in 3 Moderate Medical treatment required, onsite circumstances) and the associated likelihood of release contained with outside AC occurrence, where biological material is the source of assistance, high financial loss 4 Major Extensive injuries, loss of production harm capability, off site release with no Biological Toxins: certain plants, animals, & microbes detrimental effects, major financial loss Infectious Agents: 5 Catastrophic Death, toxic release off site with detrimental effect, huge financial loss CMLSSC Academics Committee A.Y. 2023-2024 Page 1 of 2  Biorisk Management MT-MLS 101A: Principles of Medical Laboratory Science I Safeguard sensitive biological materials & preventing their SOURCES OF RISKS use for harmful purposes. Unintentional Exposure WHY DO WE NEED BRM? ○ Accidental contact with hazard ○ Happens when there is misuse To conform to prudence biosafety/biosecurity practices; 4 Accidental Release To prevent contamination of the environment and promote 02 ○ Unintended release such as: spills, leaks, equipment environmental quality; failure Prevent loss, theft, or misuse of microorganisms, -2 Theft biological materials, and research-related information; 23 ○ Unauthorized taking/use Protect proprietary materials and information Misuse 20 ○ Improper or irresponsible use of biological agents GOAL OF BRM? Diversion ○ Re-routing of biological materials from their intended To identify and reduce risks before they evolve into near Y. use to unauthorized purposes posing security risk misses or incidents. A. Intentional Release ○ Deliberate release of harmful biological agents E ○ Often for malicious intent posing significant public health threat TE BIORISK MANAGEMENT IT A system or process to control safety and security risks MM associated with the handling or storage and disposal of biological agents and toxins in laboratories and facilities. CO –International Laboratory Biorisk Management Standard CWA 15793:2011 BIORISK MANAGEMENT STRATEGY BIOSAFETY RISK S IC The risk of accidental exposure to or release of a biological hazard. EM Example: Biosafety practice: wearing PPE, containment protocols, sterilization techniques AD BIOSECURITY RISK AC The risk of unintentional removal (theft) of a valuable biological material Focuses on preventing unauthorized access, misuse of theft of biological agents. CMLSSC Academics Committee A.Y. 2023-2024 Page 2 of 5  Biorisk Management MT-MLS 101A: Principles of Medical Laboratory Science I AMP MODEL Transference ○ Transferring the impact of a risk to a third party Assessment Acceptance ○ Hazard identification and risk assessment ○ Where in some problems cant be solved Mitigation ○ Response of doing nothing needs to be a ○ Control measures well-thought response that comes after reviewing all 4 Performance possible options and course of action. 02 ○ Review of process/implementing STEPS OF RISK ASSESSMENT -2 23 Define the situation ○ Identify the hazards and risks of the biological 20 agents to be handled ○ Location, procedures, and equipment Define the risks Y. ○ How individuals may be exposed to the hazard A. ○ Mode of transmission Characterize the risks E ○ Qualitative - descriptive ○ Quantitative - date with numbers TE Accept of reject ○ Assess the risk whether or not acceptable IT MM RISK MITIGATION THREE VITAL QUESTIONS Second fundamental component CO Actions and control measures Assessment Reduce or eliminate the risks ○ What are the risks? Five major areas of control measure Mitigation The most effective way to mitigate risks rely on the S ○ How can i reduce/eliminate the risks combination of the measures and the observance of IC Performance proper utilization. ○ How can i confirm that I have reduced/eliminated the EM risk HIERARCHY OF CONTROLS RISK MANAGEMENT KEY COMPONENTS AD RISK RESPONSE AC Mitigation ○ Reducing impact of the risk Avoidance ○ For risk that can severely impact a project CMLSSC Academics Committee A.Y. 2023-2024 Page 3 of 5  Biorisk Management MT-MLS 101A: Principles of Medical Laboratory Science I Administrative controls and practices and procedures ○ Change the way people work with the hazard ○ Delegating of the tasks and scheduling PPE ○ Nature of th hazard remains the same ○ Only protects the user 4 ○ Uncomfortable to wear 02 ○ Probability of the PPE to fail is high -2 PERFORMANCE EVALUATION 23 Last pillar of the BRM model 20 Involves a systematic process intended to achieve Elimination organizational objectives and goals. ○ Highest degree of risk reduction Regularly assessing the BRM system to ensure that it Y. ○ Eliminate of remove the risk from the environment meets the organizational goals. A. ○ Disadvantages: not always available Substitution E ○ Replacement of procedures or agents with a similar TE entity in order to reduce risks. ○ Example: use of polypropylene instead of glass Engineering IT ○ Eliminate the hazard efficiently MM ○ Most effective but most expensive ○ Example: installation of biosafety cabinets, ventilation systems, negative pressure airlock CO Administrative controls ○ Based on Standard Operating Procedures ○ Examples: standards, policies, training S PPE ○ Least effective IC ○ Devices worn by workers EM ○ Does not eliminate the hazard ○ When PPE fails, exposure happens ○ Gives minimal risk of exposure to the hazard AD ○ Example: mask, lab gown, face shields MITIGATION AC Elimination and Substitution ○ Removes or replaces the hazard Engineering controls ○ Isolate people from the hazard CMLSSC Academics Committee A.Y. 2023-2024 Page 4 of 5  Biorisk Management MT-MLS 101A: Principles of Medical Laboratory Science I References: Benitez, P. Dumaoal, O.S., Estrella, F., Mortel, F. and Nava, M.R. (2019). Principles of Medical Laboratory Science 1. C&E Publishing Inc. 4 02 PPT Presentation Courtesy of Sir Roy Martin Cerrado -2 Principles of Medical Laboratory Science Professors: 23 Sir Roy Martin Cerrado Maam Arianne Rose A. Lim 20 Transcribed by: Y. Nigella B. Rivera A. Counter Checked by: Charla Jen G. Mendez E TE IT MM CO S IC EM AD AC CMLSSC Academics Committee A.Y. 2023-2024 Page 5 of 5