L6 - Types of Normal and Abnormal Haemoglobin PDF
Document Details
Uploaded by SportyBlessing
Tags
Summary
This document covers the different types of hemoglobin, including normal and abnormal forms. It details their structures, functions, and clinical implications. It also briefly mentions methemoglobinemia, sickle cell anemia, and thalassemia.
Full Transcript
6 Types of normal and abnormal haemoglobin ILOs By the end of this lecture, students will be able to 1. Differentiate normal types of haemoglobin in terms of structure and the impact on function 2. Describe structural abnormalities in abnormal types of haemoglobin (Methaemoglobinemia, sickle cell an...
6 Types of normal and abnormal haemoglobin ILOs By the end of this lecture, students will be able to 1. Differentiate normal types of haemoglobin in terms of structure and the impact on function 2. Describe structural abnormalities in abnormal types of haemoglobin (Methaemoglobinemia, sickle cell anemia, thalassemia) 3. Deduce the clinical picture of abnormal types of haemoglobin Types of normal haemoglobin As you have learned earlier, adult haemoglobin (HbA) is formed of heme and globin (2 alpha chains and 2 beta chains). However, other types of normal haemoglobin exist such as: Name of Hb type Chain composition Fraction of total Hb HbA α2 β 2 90% HbA2 α2 δ 2 2%-3% HbF
