Inorganic Chemistry Group 2A PDF

INORGANIC CHEMISTRY M5: GROUP 2A – ALKALINE EARTH METALS GROUP 2A - Alkaline Earth Metals Allyl groups – aromatic; in rings - Be MgCa Sr BaRa (Be Magca Senior Bara)...

INORGANIC CHEMISTRY M5: GROUP 2A – ALKALINE EARTH METALS GROUP 2A - Alkaline Earth Metals Allyl groups – aromatic; in rings - Be MgCa Sr BaRa (Be Magca Senior Bara) Alkyl groups – non-ring; branch/straight chains Beryllium - Beryllos Identification Test: - Characteristics: - Biphosphate test Glucinum white crystalline ppt of magnesium ➔ Sweet taste ammonium phosphate hexahydrate ➔ “Glu” – “Glucose” – sugar (MgNH4PO4) ➔ Its compounds are sweet - Hydroxide test (NaOH) MOST toxic metal white ppt. of magnesium hydroxide which ➔ Can cause Lung Granuloma has the capacity of adsorbing color of dyes (inflammation of cell at the sight of w/ Titan yellow(produce a red lake) while tissue infection; in response to with p-nitrobenzene azo-resorcinol (blue beryllium) lake) Tends to replace Ca and Mg in the body Element and compound have no medicinal uses Magnesium - Characteristics: Second most abundant intracellular cation Mineral which magnesium is found: PISO – Most abundant intracellular cation: Potassium “in”, Most abundant extracellular cation: Sodium “out” - Talc, asbestos (stops fire in construction; can MICO – Second most abundant intracellular cation: Magnesium cause lung cancer because of the gas released), “in”, Second most abundant extracellular cation: Calcium “out” meerschaum - Magnesite, Dolomite PhiClo – Most abundant intracellular anion: Phosphate “in”, - Kieserite (MgSO4) Most abundant extracellular anion: Chloride “out” Uses: Used in research involving photosynthesis for it is present in plants specifically in - Laxative chlorophyll. - Depressant Metal present in Grignard Reagent ➔ & Sedative/Sedation (?) ➔ Used in the production/synthesis of ➔ Toxicity Tx is Calcium Gluconate alcohol - Natural Ca-channel blocker (CCB) ➔ R-Mg-X (R = Alkyl/Allyl group; Mg = ➔ Lowers BP Magnesium; X = Halogens) – chemical ➔ Meaning Magnesium can naturally formula lower BP as a CCB ☀︎ | Page 1 of 3 INORGANIC CHEMISTRY M5: GROUP 2A – ALKALINE EARTH METALS Types of Hypotensive/Antihypertensive drugs (Lowers Magnesium Hydroxide, USP BP): - Milk of Magnesia, Magnesia Magma - All have different target in heart - Mg(OH)2 - Mg(OH)2 suspension in water (7-8.5%) Angiotensin-receptor blocker (ARB) ---------------- Losartan - Uses: Ca-channel blocker ---------------------------------- Amiodipine Non systemic antacid ➔ EX: Kremil-S (Simeticone, AlOH, MgOH), Beta blocker ------------------------------------------- Metoprolol Kremil-S advance (Famotidine, Calcium Carbonate, MgOH), Maalox (AlOH, Angiotensin-converting enzyme (ACE) ------------ Captopril MgOH) Aluminum Hydroxide and Magnesium Hydroxide: Hydrated Magnesium Trisilicate, USP - Always together - Talc, talcum, purified talc, French chalk, - Why? They cancel each other’s side effects soapstone, steatite AlOH – constipation (Ala tae) - Native hydrous magnesium silicate MgOH – diarrhea (Mag tae) - Softest mineral - Smooth unctuous feel, free from grittiness (not greasy) Magnesium Oxide, USP - Use: clarifying agent (pampaclear) - Calcined magnesia - MgO - Undergone calcination Magnesium Carbonate, USP ➔ removal of CO2 from MgCO3 to produce MgO - Magnesia - Component of Universal Antidote - MgCO3 ➔ 2 activated charcoal: 1 Tannic acid: 1 - Forms: MgO Light - insoluble in water. fire extinguisher, ➔ Activated charcoal – first line of cosmetics, dusting powder, fireproofing and antidote for toxicity toothpaste. - Uses: Heavy - smoke suppressant and drying Non-Systemic Antacid agent. Saline Laxative - Uses: Antacid – kontra-acid Saline laxative Magnesium Sulfate, USP - Epsom salt - Antidote (Tx) for Magnesium Sulfate toxicity: Magnesium Citrate Calcium gluconate - Lemonada purgante, purgative lemon - Uses: - Sour in taste with a lemon flavor Saline laxative - PO - Uses: Anticonvulsant – IM Saline laxative ➔ Antiseizure ➔ Common in OB kit because seizures are common for pregnant women in labor/delivery. Fatal. ➔ DOC (10-20 ampules in kit) for: ☀︎ | Page 2 of 3 INORGANIC CHEMISTRY M5: GROUP 2A – ALKALINE EARTH METALS o Pre-eclampsia – Hypertension (HTN) + proteinuria (protein in urine) o Eclampsia – HTN + proteinuria + seizure. Deathly Anti-inflammatory Antidote (Tx) for Barium toxicity ☀︎ | Page 3 of 3