Hyperlipidemia Notes PDF
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These notes describe hyperlipidemia, a condition involving high levels of lipids in the blood. The document discusses different types of lipids, diagnosis through labs, treatment options using various medications, and potential side effects. The notes also cover the mechanisms of action of these medications.
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# Hyperlipidemia - **epithelial cells** - food in the small intestine - **interstitial space** - **capillaries/BF** - **Lymph system** ### Su... we eat: - **Prokin** - carbs (glucose) - **Lipids** - **triglyceride** - **cholesterol** - **hydrophobic** - water soluble - **phospholipids...
# Hyperlipidemia - **epithelial cells** - food in the small intestine - **interstitial space** - **capillaries/BF** - **Lymph system** ### Su... we eat: - **Prokin** - carbs (glucose) - **Lipids** - **triglyceride** - **cholesterol** - **hydrophobic** - water soluble - **phospholipids** - + prokin, now hydrophilic ### Superior vena cava - blood stream ### Dx: labs (what we want to see) - **total cholesterol** of 200- - **HDL** 40/50+ - **LDL** 100- - **Triglycerides** 150- ### Tx: yearly lipid levels - **diet** - decrease sat/trans fat - cholesterol - fiber (clean cut) ### HMG COA Reductase Inhibitors - **Statins** so: **atorvastatin** or **rosuvastatin** ### MOA: inhibit cholesterol production in liver - prokchon ### AE: - HA - fatigue, rash, itch - myalgias so: joint pain/muscle ache - **if worsen call doc** -> **rhabdomyolysis**: painful breakdown of muscle fibers - **preg x drug** ### Bile Acid Sequestrants - **cholestyramine + coleserelam** ### MOA: - prevent reabsorption of cholesterol (in diet, effective) - excrete from Gl ### Rouk: - powder in juice, TID ### AE: - poop! - GI so: constipation, nv, bloating, dyspepsia (indigestion) ### Phospholipids - build cell membranes ### Triglycerides - store fat ### Skriods - cholesterol - 80% made in liver - 20% in diet ### High levels cause atherosclerosis - narrows lumen - so ↑SVR, BP - ↑BF (PAD/CAD) ### Collects in arterial walls ### Fibric Acid - **Gemfibrozil** ### Tx: - ↑ triglycerides ### MOA: - activate lipoprotein - breakdown triglycerides ### AE: - so take w food ### Niacin - B3 vitamin ### Rouk: - 4-6 big pills/day ### AE: - hepatotoxicity, gout - ↑ DM (TBG)
