Hyperlipidemia PDF
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Summary
This document provides information on hyperlipidemia, a condition characterized by high levels of lipids (fats) in the blood. It details various treatment options for patients with the disorder.
Full Transcript
Goals hyperlipidemia ASCVD RISK general...
Goals hyperlipidemia ASCVD RISK general 1. Statin tx. and ezetimibe 2 TC automatic - #x Primary Prevention - wh Ascud events LDLL, age40-75 wh Dm , no risk age 48-75 wh Dm + risk age statin +x Statin Contra · encourage lifestyle mod to↓ ASCVD risk pregnancy ·. ages 20-39 · > Statin +X /n Premature ASCVD o LDL-160 - breastfeeding acute liver disease ages40-75 assessora ↑ LDL = 70 198 - ascua risk - 20% persistant Serum transaminase 51. 5-7 5%. 17 50%. Statin +X lifestyle mod. Statin lifestyle mod Statin (if risk). mod. if risk factor NonStatin Tx Additions 1. ezetimibe contra: combo wi statin if pregnant/ feeding or active liver disease - 2 PCSK9i alirocumab evolocumab ( + X HeFH) -curisk ,.. Bile Acid 3 Sequestrants cholestyramine, colsevelem , colestipol Secondary Prevention - w/prev ASCVD. event store revascularization Stablelunstable M angina high ASCVD not highte risk healthy lifestyle risk 1. high statin & · high statin (mod. If high not tolerate) E75y0 max add add ezetimibe (if max +x + LDL270) Statin t ezetemibe , ↳ PCSK9l. LDL > 78 · reasonable options 7yo statin 1 cont. · high. initiate 2 mod-high statin TG Triglyceride Tx persistent moderate severe fasting 150-499 > 500 > 158 adults w/ ASCVD + fasting TG 158- < 500 1 O 2 "cause.. 2 Optimize diet/life "glycemic Ctrl " 3. 4. max. Statin +X TG150 499- LD(178 LDL 78-99 LDL : 100 V V max Statin speetu. +X 1 0 2° cause. optimize tele V. 2 non statio & icosapent ethyl adults > 40 wIDm, wo ASCVD & Fasting TG 150-500 1. O 2 cause. 2 Optimize diet/life "glycemic Ctrl " 3. 4. max Statin +X. TG 150-499 W - < 50y0W/1 250 or 150 who add age high risk ASCUD Factor ASCVD Factors & ezetimibe 9PCSKAi icosapentul adults 120 wo DM , no ASCUD & TG 150-500 ° 1. ① 2 cause. die+ /life 2 TG 150 - 499740- 75y8 5% 18 yu 220% ASCUK - & W 5 + 220% 1. dietlife high risk L Statin. assess 2 periodically Start/ +X increase Statin +x adults =20 wITG 1500 TG21008 TG 500-999 1. 82 cause 23 3940 OR N 40 75y0 : TG500-999 wI. low 2 fat diet/life TG300-99945/AS - - 40-75 : 20 cause ↳ 5 % risk , ASCVD , or DM Or TG ! 500-999WODMptimizedielect. optimize 3 glycemic ctul TG = 500-999 4. - - Fibrate , Omega 3 FA · low fat diet I. low fat diet. Statin 5 (begin/intensify) fibrates 2 ↑ statin. intensity = mega-3 FA. fibrates 3 = mega-3 FA
