RxPrep Drug Compatibility Guidelines PDF

Summary

This document provides guidelines on the compatibility of various drugs, particularly for intravenous (IV) administration. It details which medications can be mixed with dextrose or saline solutions. It also highlights the need for light protection for certain drugs.

Full Transcript

. RxPrep Course Book | RxPrep © 2019 RxPrep © 2020 SPECIAL REQUIREMENTS TAKE WITH / WITHOUT FOOD Most antibiotics can be taken with food to decrease Gl upset; except these drugs, which are different. Take within one hour of finishing a meal: amoxicillin ER Take on an empty stomach: ampicillin ora...

. RxPrep Course Book | RxPrep © 2019 RxPrep © 2020 SPECIAL REQUIREMENTS TAKE WITH / WITHOUT FOOD Most antibiotics can be taken with food to decrease Gl upset; except these drugs, which are different. Take within one hour of finishing a meal: amoxicillin ER Take on an empty stomach: ampicillin oral capsules and suspension, ceftibuten suspension, levofloxacin oral solution, penicillin VK, rifampin*, isoniazid’, itraconazole solution’, voriconazole’ 1:1 IV TO ORAL DOSING For these drugs, the oral and IV dose is the same. Levofloxacin, moxifloxacin Doxycycline, minocycline Sulfamethoxazole/ Trimethoprim Linezolid, tedizolid Metronidazole Fluconazole*, isavuconazonium’, posaconazole’ (oral tablets and IV), voriconazole’ LIGHT PROTECTION DURING ADMINISTRATION See the Learning IV Medications chapter for a complete list of drugs (including antibiotics and other drugs) that require specific light protection. Doxycycline Micafungin’ Pentamidine’ DILUENT COMPATIBILITY REQUIREMENTS See the Learning IV Medications chapter for a complete list of drugs (including antibiotics and other drugs) that require specific diluents. Compatible with dextrose only Dalbavancin, oritavancin Pentamidine* Quinupristin/ Dalfopristin Sulfamethoxazole/Trimethoprim Amphotericin B * (conventional, Abelcet , Ambisome) Compatible with saline only Ampicillin Ampicillin/Sulbactam Ertapenem Daptomycin (Cubicin RF - see the daptomycin drug table for reconstitution requirements prior to dilution) Compatible with NS/ LR only Caspofungin* Daptomycin (Cubicin ) * These drugs are discussed in the ID ll - IV chapters. . Lactatad Klng*r

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