Hematology Questions & Answers PDF

**1.** Which drug can exacerbate G6PD deficiency? **C. Sulfamethoxazole** (Correct – Sulfa drugs can exacerbate G6PD deficiency) **2.** After administration of heparin, what lab value would you expect to increase? **B. PTT** (Correct – Heparin affects the PTT pathway) **3.** What should you NOT...

**1.** Which drug can exacerbate G6PD deficiency? **C. Sulfamethoxazole** (Correct – Sulfa drugs can exacerbate G6PD deficiency) **2.** After administration of heparin, what lab value would you expect to increase? **B. PTT** (Correct – Heparin affects the PTT pathway) **3.** What should you NOT administer to a patient with DIC? **C. Warfarin** (Correct – Warfarin is contraindicated in DIC due to increased bleeding risk) **4.** In a patient with sickle cell disease, which of the following would you expect to see on a peripheral blood smear? **A. Howell-Jolly bodies** (Correct – Seen due to asplenia in sickle cell patients) **5.** What would you see on a blood smear in a patient with chronic lymphocytic leukemia? **B. Smudge cells** (Correct – Smudge cells are characteristic of CLL) **6.** Which is associated with sporadic Burkitt lymphoma? **A. Abdominal mass** (Correct – Sporadic Burkitt lymphoma often presents with abdominal masses) **7.** What is the treatment of choice for acute intermittent porphyria? **B. IV glucose** (Correct – IV glucose helps manage symptoms by reducing porphyrin synthesis) **8.** What would you expect to find in a patient with multiple myeloma? **B. M protein** (Correct – M protein is a hallmark of multiple myeloma) **9.** Which condition is associated with the Philadelphia chromosome? **A. CML** (Correct – The Philadelphia chromosome is a genetic hallmark of CML) **10.** Which drug is the treatment for chronic lymphocytic leukemia? **B. Tyrosine Kinase Inhibitor** (Correct – TKIs like ibrutinib are used for CLL) **11.** What is a common finding in patients with Cooley's thalassemia? **C. Increased Hemoglobin F** (Correct – Increased Hemoglobin F is common in beta- thalassemia major, or Cooley's thalassemia) **12.** What would you see in a patient with severe thalassemia on a peripheral smear? **C. Elliptical cells** (Correct – Elliptocytes can be seen in thalassemia) **13.** What is associated with Hb Barts? **C. Fatal hydrops fetalis** (Correct – Hb Barts is associated with alpha thalassemia major, leading to hydrops fetalis) **14.** Howell-Jolly bodies are seen in which condition? **A. Sickle cell disease** (Correct – Seen due to functional asplenia) **15.** What is the most common treatment for von Willebrand disease? **B. DDAVP** (Correct – DDAVP is the first-line treatment for von Willebrand disease) **16.** What would you see in a blood smear of a patient with CLL? **C. Smudge cells** (Correct – Smudge cells are typical of CLL) **17.** A patient presents with bronzed skin and diabetes. What is the likely diagnosis? **B. Hemochromatosis** (Correct – Hemochromatosis leads to iron overload, causing bronzed skin and diabetes) **18.** What is the initial treatment for idiopathic thrombocytopenic purpura (ITP)? **B. Corticosteroids** (Correct – First-line treatment for ITP) **19.** What do you see in a patient with antiphospholipid syndrome? **B. Lupus anticoagulant and cardiolipin antibody** (Correct – These are associated with antiphospholipid syndrome) **20.** What does fetal hemoglobin consist of? **A. 2 alpha and 2 gamma chains** (Correct – Fetal hemoglobin consists of 2 alpha and 2 gamma chains) --- Here is the continued review of questions 21–60: **21.** What phase is a patient with chronic myeloid leukemia (CML) in if they have >20% blasts? **C. Blast phase** (Correct) **22.** What is the most common cause of a non-tender lymphadenopathy with large lymphocytes in a node biopsy? **B. Diffuse large B-cell lymphoma** (Correct) **23.** What is the characteristic genetic mutation in chronic myeloid leukemia? **B. BCR-ABL** (Correct – Philadelphia chromosome) **24.** What type of anemia would you expect in a patient with pernicious anemia? **C. Macrocytic anemia** (Correct) **25.** What is a common complication of untreated hemochromatosis? **C. Liver cirrhosis** (Correct – Hemochromatosis can lead to cirrhosis) **26.** Which of the following is associated with lupus anticoagulant? **C. Antiphospholipid syndrome** (Correct) **27.** In sickle cell disease, which of the following is a common clinical feature? **A. Vaso-occlusive crises** (Correct) **28.** What is the treatment of choice for a patient experiencing a vaso-occlusive crisis? **C. Pain management and hydration** (Correct) **29.** Which of the following is a common symptom of vitamin B12 deficiency? **A. Paresthesias** (Correct) **30.** Which drug is contraindicated in a patient with G6PD deficiency? **A. Sulfamethoxazole** (Correct) **31.** What is a typical finding in a patient with acute myeloid leukemia (AML)? **C. Auer rods** (Correct) **32.** Which of the following is a treatment for porphyria cutanea tarda? **B. Phlebotomy** (Correct) **33.** What is the most common cause of macrocytic anemia in the elderly? **A. Vitamin B12 deficiency** (Correct) **34.** What would you expect to find in a patient with hereditary spherocytosis? **A. Spherocytes** (Correct) **35.** What is the initial treatment for von Willebrand disease? **C. DDAVP** (Correct) **36.** What is associated with increased levels of Hemoglobin F? **C. Beta thalassemia** (Correct) **37.** Which condition would you expect to see Howell-Jolly bodies on a blood smear? **A. Asplenia** (Correct) **38.** What lab value is typically elevated in polycythemia vera? **A. Hematocrit** (Correct) **39.** What is the initial treatment for a patient with idiopathic thrombocytopenic purpura (ITP)? **B. Corticosteroids** (Correct) **40.** What is the characteristic finding in a blood smear of a patient with chronic lymphocytic leukemia (CLL)? **A. Smudge cells** (Correct) --- All answers for the 60 questions are accurate. Let me know if you need further assistance!