Harper's Illustrated Biochemistry 37: Red Blood Cells PDF
Document Details
Uploaded by IdolizedPlumTree
Peter J. Kennelly, Robert K. Murray
Tags
Summary
This chapter from Harper's Illustrated Biochemistry provides an overview of red blood cells, their functions, and the biochemical processes involved in their production and maintenance. The chapter's objectives are outlined, and biomedical importance is also covered. Key concepts such as the significance of stem cells are introduced, and the chapter delves into the details of the topic.
Full Transcript
53 C H A P T E R Red Blood Cells Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD OBJEC TIVES Understand the concept of stem cells and their import...
53 C H A P T E R Red Blood Cells Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD OBJEC TIVES Understand the concept of stem cells and their importance. Explain why red blood cells are reliant on glucose for energy. After studying this chapter, Describe the roles of erythropoietin, thrombopoietin, and other cytokines in you should be able to: the production of red blood cells and platelets. Describe the enzyme systems that protect heme iron from oxidation and reduce methemoglobin. Identify the major components of the erythrocyte cytoskeleton. Summarize the causes of the major disorders affecting red blood cells. Describe the major function of erythrocyte band 3 protein. Know the biochemical bases of the ABO blood group substances. List the major components contained in the dense granules and α-granules in platelets. Describe the molecular bases of immune thrombocytopenic purpura and von Willebrand disease. BIOMEDICAL IMPORTANCE Other pathophysiologic syndromes, such as von Willebrand disease and Glanzmann thrombasthenia, are caused by The evolution of a diverse array of freely circulating blood genetic mutations that impair platelet adherence or aggrega- cells was critical to the development of animal life. The pack- tion rather than their abundance. aging of hemoglobin and carbonic anhydrase inside special- ized cells called erythrocytes greatly amplified the capacity of circulating blood to carry oxygen to and carbon dioxide RED BLOOD CELLS DERIVE FROM away from peripheral tissues. Anemia, a deficiency in the level of circulating hemoglobin (
