Gluco.pdf

Gluconeogenesis Firstly, Pyruvate is converted to Oxaloacetate in mitchondria Pyruvate + CO2 + ATP + H2O? Oxaloacetate + ADP +Pi +2H+ Activated by Pyruvate carboxylase Acetyl CoA activates the enzymes Pyruvate is transported into mitochondria where its converted Secondly, Oxaloacetate is converted i...

Gluconeogenesis Firstly, Pyruvate is converted to Oxaloacetate in mitchondria Pyruvate + CO2 + ATP + H2O? Oxaloacetate + ADP +Pi +2H+ Activated by Pyruvate carboxylase Acetyl CoA activates the enzymes Pyruvate is transported into mitochondria where its converted Secondly, Oxaloacetate is converted into Malate as mitochondria doesnot have transporter for Oxaloacetate. Oxaloacetate + NADH + H+? Malate + NAD+ Once Malate exits the cytoplasm, its oxidised back into Oxaloacetate Thirdly, Oxaloacetate is converted into Phosphoenolpyruvate, catalysed by phosphoenolpyruvate carboxykinase Oxaloacetate + GTP ? Phosphoenolpyruvate + GDP + CO2 Forthly, Fructose 1,6 -bisphosphate is converted into fructose-6-Phosphate, catalysed by fructose-1,6-bisphosphatase Glucose-6-Phosphate is converted into Glucose, catalysed by glucose-6-phosphatase Overall= Glucose+ 4 ADP+ 2 GDP + 6Pi + 2 NAD+