Final Immune Senior Exam Paper PDF

Final- Immune senior 1. What is the action mechanism of activation-induced deaminase (AID) in H-chain switching? Select one: a. Induce VDJ recombination b. Ligation c. RNA splicing d. Convert nucleotide C to U and...

Final- Immune senior 1. What is the action mechanism of activation-induced deaminase (AID) in H-chain switching? Select one: a. Induce VDJ recombination b. Ligation c. RNA splicing d. Convert nucleotide C to U and cleavage e. none 2. What is the primary role of CD40 activation in APCs? Select one: a. Full activation b. Secret granules c. Enhance capturing antigen d. Enhance APC migration e. Activate complement system 3. What is the role of ubiquitin in class- MHC pathway? Select one: a. Exchange peptide b. Recycling peptide to membrane c. Direct degrade proteins d. Display antigen peptides e. Tag and transport proteing to proteasome 4. Which cytotoxic molecule secreted by cytotoxic T lymphocytes to kill virus-infected cells? Select one: a. IFN-a b. Lysosomal protease c. Antimicrobial peptides d. Membrane attack complex e. Granzyme Final- Immune senior 1  5. How IgG can survive in longer period comparing to the other lg isotypes? Select one: a. Most abundent b. Affinity maturation c. Having most subset IgG d. Strong Fc domains e. Ingest via endosome & recycling back 6. Which enzyme play key role in the lg H-chain switching? Select one: a. VDJ recombinase b. Protease c. Activated-induced deaminase (AID) d. Dnase e. Ligase 7. During the infection, why antigen-specific clones of CD8+T cells increase higher in number then CD4+T cells? Select one: a. Stimulate other leukocytes b. Prevent from entering of microbes C. Activate B cells d. Sufficient kill the infected cells e. Enhance phagocytosis 8. Among the five lg isotypes, which one does NOT switch its H-chain to be another lg isotype? Select one: a. IgM b. IgD c. IgA d. IgD e. IgE 9. Naive B cells will be differentiated to be lgA-expressing B cells, if they will be activated by Select one: a. IL-1 Final- Immune senior 2  b. IL-2 c. IFNy d. IL-22 e. TGF-ß 10. How IgA could protect itself from being degraded by the protease enzyme in the mucosal fluid? Select one: a. Gain additional hypermutation b. Associated with poly-lg protein c. Increase affinity maturation d. Protected by other complement proteins e. All of them 11. How CD8+T cells recognize the virus-infected cells and mediate their cytotoxicity? Select one: a. Antigen peptide on class-I MHC b. Antigen peptide on class-Il MHC c. Death receptor d. Inhibitory receptor e. Lipopolysaccharide 12. What is the primary role of CD40 activation in APCs? Select one: a. Full activation b. Secret granules 6. Enhance capturing antigen d. Enhance APC migration e. Activate complement system 13. To increase affinity maturation of lg, B cells need to go through Select one: a. Hypersomatic mutation b. T-indepent activation c. Various signaling activation d. Activation of CD28 e. IL-2 autocrine Final- Immune senior 3  14. How Tfh cells migrate toward follicular tissue in order to activate B cells? Select one: a. Express more CD40L b. Downregulate CD28 c. Express adhesion molecule d. Express more CCR7 e. Increase express of CXCR5 15. Which lg isotype that function in the elimination of helminth? Select one: a. IgA b. lgD C. IgE d. IgG e. lgM 16. During the infection, why antigen-specific clones of CD8+T cells increase higher in number then CD4+T cells? Select one: a. Stimulate other leukocytes b. Prevent from entering of microbes c. Activate B cells d. Sufficient kill the infected cells e. Enhance phagocytosis 17. Which enzyme play key role in the lg H-chain switching? Select one: a. VDJ recombinase b. Protease C. Activated-induced deaminase (AID) d. Dnase e. Ligase 18. What is the action mechanism of activation-induced deaminase (AID) in H-chain switching? Select one: a. Induce VDJ recombination b. Ligation Final- Immune senior 4  c. RNA splicing d. Convert nucleotide C to U and cleavage e. Non of them 19. In the junctional divesity of somatic recombination, an enzyme called..... will remove the nucleotides from VDJ recombinant. Select one: a. VDJ recombinase b. Ligase c. Exonuclease d. TdT (transferase) e. Protease 20. To increase affinity maturation of lg, B cells need to go through Select one: a. Hypersomatic mutation b. T-indepent activation c. Various signaling activation d. Activation of CD28 e. IL-2 autocrine 21. Which immune component has the function in neutralize microbe and its toxin? Select one: a. TCR complex b. Toll-like receptor c. Antibody d. Lectin receptor e. BCR complex 22. How neonate protect themselves from the infection? Select one: a. Activate its lymphocyte b. Able to resist with infection c. Produce large abs d. Aquiring abs from maternal e. Complete develop immunity Final- Immune senior 5  23. Which lg isotype will be produced by T-indepent activation of B cells? Select one: a. IgA b. IgM c. IgG1 d. IgE e. IgG2 24. Naive B cells will be differentiated to be IgA-expressing B cells, if they will be activated by Select one: a. IL-1 b. IL-2 c. IFNy d. IL-22 e. TGF-ß 25. Which Th cell play role in the selection of the specific-lg producing B cells in GC? Select one: a. Th1 cell b. Th2 cell C. Th cell d. Regulatory Th cell e. Th17 cell 26. How IgG can survive in longer period comparing to the other lg isotypes? Select one: a. Most abundent b. Affinity maturation c. Having most subset IgG d. Strong Fc domains e. Ingest via endosome & recycling back 27. What is the function of C3a and C5a in the complement activation? Select one: a. Induce phagocytosis b. Induce inflammatory C. Generate membrane attack complex Final- Immune senior 6  d. join in Ç3 convertase e. Join in C5 convertase 28. Which cytotoxic molecule secreted by cytotoxic T lymphocytes to kill virus-infected cells? Select one: a. IFN-a b. Lysosomal protease c. Antimicrobial peptides d. Membrane attack complex e. Granzyme 29. During VDJ recombination, there is an enzyme called Ligas that play critical role in Select one: a. Repair the broken DNA b. Remove nucleotide to VDJ sequence C. Add nucleotide to VDJ sequence d. Splicing RNA sequence e. Breaking sequence 30. Which B cell subset functions in somatic hypermutation? Select one: a. Follicular B cells b. B-1 cells c. zone B cells d. Hybridoma cells e. All of them 31. The effector mechanism of CD8+T cells is different from CD4+ Th cells because thev Select one: a. Activate APCs b. Kill virus-infected cells c. Promote tissue repair d. Down regulate other cells e. Recruit neutrophil migration 32. What is the role of ubiquitin in class- MHC pathway? Select one: Final- Immune senior 7  a. Exchange peptide b. Recycling peptide to membrane c. Direct degrade proteins d. Display antigen peptides e. Tag and transport protein to proteasome 33. What is the purpose of making membrane attack complex (MAC) in complement activation? Select one: a. Lysis microbe b. Degrade protein C. Activate ADCC d. Activate phagocyte e. Ingest microbe 34. What is the action mechanism of activation-induced deaminase (AID) in H-chain switching? Select one: a. Induce VDJ recombination b. Ligation C. RNA splicing d. Convert nucleotide C to U and cleavage e. None of them 35. Among the five lg isotypes, which one does NOT switch its H-chain to be another lg isotype? Select one: a. IgM b. IgD c. IgA d. IgD e. IgE Final- Immune senior 8