Immunology Mechanisms Overview

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Questions and Answers

Which immunoglobulin isotype does not switch its heavy chain to become another isotype?

  • IgA
  • IgM
  • IgE
  • IgD (correct)

What activation factor differentiates naive B cells into IgA-expressing B cells?

  • TGF-ß (correct)
  • IL-1
  • IL-2
  • IL-22

How does IgA protect itself from degradation in mucosal fluid?

  • Protected by other complement proteins
  • Indeed, all of these options
  • Gain additional hypermutation
  • Associated with poly-Ig protein (correct)

What mechanism do CD8+ T cells use to recognize virus-infected cells?

<p>Antigen peptide on class-I MHC (D)</p> Signup and view all the answers

What is the primary role of CD40 activation in antigen-presenting cells (APCs)?

<p>Full activation (D)</p> Signup and view all the answers

What process do B cells undergo to increase the affinity maturation of immunoglobulins?

<p>Hypersomatic mutation (D)</p> Signup and view all the answers

How do Tfh cells migrate toward follicular tissue to activate B cells?

<p>Chemokine gradients (C)</p> Signup and view all the answers

What is a key feature of IgE in the immune response?

<p>Binds to mast cells and basophils (A)</p> Signup and view all the answers

Which mechanism is primarily responsible for the switching of immunoglobulin heavy chains?

<p>Activation-induced deaminase (AID) (C)</p> Signup and view all the answers

What is the specific role of activation-induced deaminase (AID) during H-chain switching?

<p>Convert nucleotide C to U and cleavage (A)</p> Signup and view all the answers

Which immunoglobulin isotype is crucial for the elimination of helminths?

<p>IgE (B)</p> Signup and view all the answers

What role does CD8+ T cell play in increasing the number of antigen-specific clones compared to CD4+ T cells during infection?

<p>Sufficiently kill infected cells (D)</p> Signup and view all the answers

Which enzyme is responsible for removing nucleotides from VDJ recombinant in junctional diversity?

<p>Exonuclease (D)</p> Signup and view all the answers

What process do B cells undergo to enhance affinity maturation of immunoglobulin?

<p>Hypersomatic mutation (B)</p> Signup and view all the answers

Which immune component is responsible for neutralizing microbes and their toxins?

<p>Immunoglobulins (D)</p> Signup and view all the answers

Which receptor is involved in the expression of CD28 in T cell activation?

<p>CD40L (C)</p> Signup and view all the answers

What is the action mechanism of activation-induced deaminase (AID) in H-chain switching?

<p>Convert nucleotide C to U and cleavage (A)</p> Signup and view all the answers

What is the primary role of CD40 activation in antigen-presenting cells (APCs)?

<p>Full activation (D)</p> Signup and view all the answers

What is the role of ubiquitin in the class-MHC pathway?

<p>Tag and transport proteins to proteasome (B)</p> Signup and view all the answers

Which cytotoxic molecule is secreted by cytotoxic T lymphocytes to kill virus-infected cells?

<p>Granzyme (C)</p> Signup and view all the answers

Why can IgG survive longer compared to other immunoglobulin isotypes?

<p>Strong Fc domains (C)</p> Signup and view all the answers

Which enzyme plays a key role in immunoglobulin H-chain switching?

<p>Activation-induced deaminase (AID) (B)</p> Signup and view all the answers

During infection, why do antigen-specific clones of CD8+ T cells increase in number more than CD4+ T cells?

<p>Directly kill infected cells (A)</p> Signup and view all the answers

Which of the following describes the function of MHC molecules?

<p>Present antigen peptides to T cells (B)</p> Signup and view all the answers

How do neonates primarily protect themselves from infections?

<p>Acquire antibodies from maternal sources (A)</p> Signup and view all the answers

Which Ig isotype is produced through T-independent activation of B cells?

<p>IgM (B)</p> Signup and view all the answers

What factor must activate naive B cells to differentiate into IgA-expressing B cells?

<p>TGF-ß (D)</p> Signup and view all the answers

Which type of T helper cell is important in selecting specific Ig-producing B cells in the germinal center?

<p>Th2 cell (D)</p> Signup and view all the answers

What characteristic allows IgG to survive longer compared to other Ig isotypes?

<p>Undergoes affinity maturation (A)</p> Signup and view all the answers

What role do the complement proteins C3a and C5a play in the immune response?

<p>They promote inflammation (C)</p> Signup and view all the answers

Which cytotoxic molecule do cytotoxic T lymphocytes secrete to eliminate virus-infected cells?

<p>Granzyme B (B)</p> Signup and view all the answers

Which receptor complex is primarily involved in recognizing pathogen-associated molecular patterns?

<p>Toll-like receptor (C)</p> Signup and view all the answers

What is the primary function of the enzyme Ligas during VDJ recombination?

<p>Repair the broken DNA (A)</p> Signup and view all the answers

Which B cell subset is specifically involved in somatic hypermutation?

<p>Follicular B cells (D)</p> Signup and view all the answers

How do CD8+ T cells primarily differ in their effector function from CD4+ Th cells?

<p>Kill virus-infected cells (D)</p> Signup and view all the answers

What role does ubiquitin play in the class-MHC pathway?

<p>Tag and transport protein to proteasome (D)</p> Signup and view all the answers

What is the primary purpose of forming the membrane attack complex (MAC) during complement activation?

<p>Lysis of microbes (D)</p> Signup and view all the answers

What action mechanism is performed by activation-induced deaminase (AID) during heavy chain switching?

<p>Convert nucleotide C to U and cleavage (D)</p> Signup and view all the answers

Among the five immunoglobulin (Ig) isotypes, which one does NOT switch its heavy chain to become another Ig isotype?

<p>IgD (D)</p> Signup and view all the answers

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