Exam 3 PQ_2 PDF

Lecture 19 1. What regions of the recombinant antibody are human derived? Variable regions Constant regions Both variable and constant regions 2. Which of the following is a possible mechanism of action of Rituxan®? B lymphocyte activation Neutralization Complement activation(IgG can activat...

Lecture 19 1. What regions of the recombinant antibody are human derived? Variable regions Constant regions Both variable and constant regions 2. Which of the following is a possible mechanism of action of Rituxan®? B lymphocyte activation Neutralization Complement activation(IgG can activate complement.) Mast cell degranulation All of the above 3. When Fab fragments are used as antidotes for drug toxicity, the function of the fragments is to ____________. opsonize the drug neutralize the drug(There is no Fc region to impart an antibody effector function!) lyse the drug promote phagocytic clearance of the drug all of the above are functions of Fab fragments used as drugs 4. Trifunctional antibodies used as immunotherapeutic agents are antibodies have two different Fab regions, allowing these antibodies to bind to two different antigens. Correct answer: True False 5. The source or origin of which of the following monoclonal antibodies is 100% human? Alemtuzumab Golimumab(Monoclonal antibodies that have a "u" in front of "mab" are 100% human.) Infliximab Tositumomab Etaracizumab 6. You are performing an ELISA assay to determine if a patient has Covid-19. The primary antibody is a monoclonal targeting the spike protein and was purified from rabbits. What antibody would you select as a secondary antibody? Anti-rabbit conjugated to horse radish peroxidase No answer text provided. No answer text provided. No answer text provided. 7. Hemlibra is a bispecific antibody without Fc function. What is notable about this class of antibody-based therapy? Bispecific antibodies are engineered to have two different antigen binding sites No answer text provided. No answer text provided. No answer text provided.