Drugs Used in Mood Disorders Part 5 PDF

\#\#\# \*\*Slide 41: Monoamine Oxidase Inhibitors (MAOIs)\*\* 1\. \*\*What is the primary mechanism of action of MAOIs in the treatment of mood disorders?\*\* \- A. Inhibition of serotonin and norepinephrine reuptake \- B. Inhibition of the enzyme monoamine oxidase, preventing the breakdown of ne...

\#\#\# \*\*Slide 41: Monoamine Oxidase Inhibitors (MAOIs)\*\* 1\. \*\*What is the primary mechanism of action of MAOIs in the treatment of mood disorders?\*\* \- A. Inhibition of serotonin and norepinephrine reuptake \- B. Inhibition of the enzyme monoamine oxidase, preventing the breakdown of neurotransmitters \- C. Activation of dopamine receptors \- D. Inhibition of GABA receptors \*\*Answer:\*\* B. Inhibition of the enzyme monoamine oxidase, preventing the breakdown of neurotransmitters【62:0†source】 2\. \*\*Which type of food must be avoided while taking MAOIs due to the risk of hypertensive crisis?\*\* \- A. High-protein foods \- B. Tyramine-rich foods (e.g., cheese, red wine) \- C. Fatty foods \- D. Carbohydrate-rich foods \*\*Answer:\*\* B. Tyramine-rich foods (e.g., cheese, red wine)【62:0†source】 3\. \*\*Which isoform of monoamine oxidase is responsible for degrading serotonin, norepinephrine, and dopamine?\*\* \- A. MAO-B \- B. MAO-A \- C. COMT \- D. SERT \*\*Answer:\*\* B. MAO-A【62:0†source】 \-\-- \#\#\# \*\*Slide 42: MAOI Side Effects\*\* 1\. \*\*Which side effect is most commonly associated with MAOIs?\*\* \- A. Hypertension \- B. Orthostatic hypotension \- C. Hypercalcemia \- D. Bradycardia \*\*Answer:\*\* B. Orthostatic hypotension【62:0†source】 2\. \*\*MAOIs are associated with the highest rate of which of the following side effects?\*\* \- A. Sexual dysfunction \- B. Weight loss \- C. Constipation \- D. Hepatotoxicity \*\*Answer:\*\* A. Sexual dysfunction【62:0†source】 3\. \*\*Which of the following conditions is associated with discontinuation syndrome upon sudden cessation of MAOIs?\*\* \- A. Psychosis, excitement, and confusion \- B. Seizures and coma \- C. Hyperglycemia and tremors \- D. Bradycardia and hypotension \*\*Answer:\*\* A. Psychosis, excitement, and confusion【62:0†source】 \-\-- \#\#\# \*\*Slide 43: Bupropion (Wellbutrin)\*\* 1\. \*\*What is the primary mechanism of action of bupropion (Wellbutrin)?\*\* \- A. Selective serotonin reuptake inhibitor (SSRI) \- B. Norepinephrine and dopamine reuptake inhibitor \- C. Monoamine oxidase inhibitor (MAOI) \- D. GABA agonist \*\*Answer:\*\* B. Norepinephrine and dopamine reuptake inhibitor【62:0†source】 2\. \*\*In which patient population should bupropion be avoided due to the risk of seizures?\*\* \- A. Patients with a history of hypertension \- B. Patients with a history of seizure disorder \- C. Patients with schizophrenia \- D. Patients with bipolar disorder \*\*Answer:\*\* B. Patients with a history of seizure disorder【62:0†source】 3\. \*\*Which of the following is an advantage of bupropion compared to SSRIs?\*\* \- A. Lower risk of sexual side effects \- B. Greater sedative effects \- C. Faster onset of action \- D. Increased serotonin reuptake \*\*Answer:\*\* A. Lower risk of sexual side effects【62:0†source】 \-\-- \#\#\# \*\*Slide 44: Dextromethorphan/Bupropion ER (Auvelity)\*\* 1\. \*\*Dextromethorphan in Auvelity works as an antagonist of which receptor?\*\* \- A. GABA-A receptor \- B. NMDA receptor \- C. Dopamine receptor \- D. Alpha-1 receptor \*\*Answer:\*\* B. NMDA receptor【62:0†source】 2\. \*\*Which drug is combined with dextromethorphan in Auvelity to enhance its antidepressant effects?\*\* \- A. Fluoxetine \- B. Bupropion \- C. Venlafaxine \- D. Mirtazapine \*\*Answer:\*\* B. Bupropion【62:0†source】 3\. \*\*What serious adverse reaction can occur when combining dextromethorphan with other serotonergic medications?\*\* \- A. Hypertensive crisis \- B. Serotonin syndrome \- C. Hypercalcemia \- D. Bradycardia \*\*Answer:\*\* B. Serotonin syndrome【62:0†source】 \-\-- \#\#\# \*\*Slide 45: Trazodone (Desyrel)\*\* 1\. \*\*What is the primary use of trazodone at low doses (25-150 mg)?\*\* \- A. Antidepressant \- B. Insomnia treatment \- C. Antipsychotic \- D. Weight loss \*\*Answer:\*\* B. Insomnia treatment【62:0†source】 2\. \*\*Which receptor blockade is responsible for trazodone's sedative effects?\*\* \- A. NMDA receptor \- B. Histamine H1 receptor \- C. GABA receptor \- D. Dopamine D2 receptor \*\*Answer:\*\* B. Histamine H1 receptor【62:0†source】 3\. \*\*What is a rare but serious side effect of trazodone?\*\* \- A. Serotonin syndrome \- B. Priapism \- C. Agranulocytosis \- D. Hepatitis \*\*Answer:\*\* B. Priapism【62:0†source】 \-\-- \#\#\# \*\*Slide 46: Nefazodone\*\* 1\. \*\*What receptor does nefazodone block that contributes to its antidepressant effects?\*\* \- A. 5-HT2A receptor \- B. Dopamine D2 receptor \- C. NMDA receptor \- D. Beta-1 receptor \*\*Answer:\*\* A. 5-HT2A receptor【62:0†source】 2\. \*\*Nefazodone is chemically related to which of the following antidepressants?\*\* \- A. Trazodone \- B. Mirtazapine \- C. Bupropion \- D. Venlafaxine \*\*Answer:\*\* A. Trazodone【62:0†source】 3\. \*\*Why is nefazodone no longer commonly prescribed?\*\* \- A. Risk of hepatotoxicity \- B. Risk of seizures \- C. High rate of weight gain \- D. Increased risk of serotonin syndrome \*\*Answer:\*\* A. Risk of hepatotoxicity【62:0†source】 \-\-- \#\#\# \*\*Slide 47: Mirtazapine (Remeron)\*\* 1\. \*\*What is the mechanism of action of mirtazapine?\*\* \- A. Alpha-2 receptor antagonist \- B. Dopamine D2 receptor antagonist \- C. GABA receptor agonist \- D. NMDA receptor antagonist \*\*Answer:\*\* A. Alpha-2 receptor antagonist【62:0†source】 2\. \*\*Which of the following is a common side effect of mirtazapine?\*\* \- A. Weight gain \- B. Hypertension \- C. Tachycardia \- D. Nausea \*\*Answer:\*\* A. Weight gain【62:0†source】 3\. \*\*Mirtazapine is less likely to cause which of the following side effects compared to SSRIs?\*\* \- A. Sexual dysfunction \- B. Weight gain \- C. Sedation \- D. Dry mouth \*\*Answer:\*\* A. Sexual dysfunction【62:0†source】 \-\-- \#\#\# \*\*Slide 48: Vortioxetine (Trintellix)\*\* 1\. \*\*Which of the following receptors does vortioxetine partially agonize?\*\* \- A. 5-HT1A \- B. NMDA \- C. Alpha-2 adrenergic \- D. Dopamine D2 \*\*Answer:\*\* A. 5-HT1A【62:0†source】 2\. \*\*Which of the following is a common side effect of vortioxetine?\*\* \- A. Diarrhea \- B. Headache \- C. Tachycardia \- D. Weight loss \*\*Answer:\*\* B. Headache【62:0†source】 3\. \*\*Vortioxetine primarily inhibits which transporter in the treatment of depression?\*\* \- A. SERT (Serotonin transporter) \- B. DAT (Dopamine transporter) \- C. NET (Norepinephrine transporter) \- D. GAT (GABA transporter) \*\*Answer:\*\* A. SERT (Serotonin transporter)【62:0†source】