Drugs for Movement Disorders Part 2.docx

**Slide 19 - Dopamine Agonists (Pramipexole, Ropinirole)** 1. **What is the primary mechanism of action for pramipexole?** - A\) D2 and D3 receptor agonist - B\) Dopamine reuptake inhibitor - C\) MAO-B inhibitor - D\) COMT inhibitor\ **Answer**: A) D2 and D3 rec...

**Slide 19 - Dopamine Agonists (Pramipexole, Ropinirole)** 1. **What is the primary mechanism of action for pramipexole?** - A\) D2 and D3 receptor agonist - B\) Dopamine reuptake inhibitor - C\) MAO-B inhibitor - D\) COMT inhibitor\ **Answer**: A) D2 and D3 receptor agonist 2. **Which dopamine agonist is more selective for D2 receptors?** - A\) Pramipexole - B\) Ropinirole - C\) Bromocriptine - D\) Pergolide\ **Answer**: B) Ropinirole 3. **What is a possible side effect of dopamine agonists like pramipexole and ropinirole?** - A\) Hyperactivity - B\) Sleep attacks - C\) Tachycardia - D\) Increased blood pressure\ **Answer**: B) Sleep attacks **Slide 20 - Dopamine Agonists (Rotigotine)** 4. **What is the route of administration for rotigotine?** - A\) Oral - B\) Transdermal patch - C\) Intravenous - D\) Subcutaneous injection\ **Answer**: B) Transdermal patch 5. **Which of the following is NOT a side effect of rotigotine?** - A\) Postural hypotension - B\) Hallucinations - C\) Diarrhea - D\) Peripheral edema\ **Answer**: C) Diarrhea 6. **What is a unique feature of rotigotine compared to other dopamine agonists?** - A\) Provides continuous dopaminergic stimulation - B\) Requires renal dose adjustment - C\) Administered via inhalation - D\) Primarily affects serotonin receptors\ **Answer**: A) Provides continuous dopaminergic stimulation **Slide 21 - MAO-B Inhibitors** 7. **Which enzyme is inhibited by MAO-B inhibitors like selegiline and rasagiline?** - A\) COMT - B\) Dopamine decarboxylase - C\) Monoamine oxidase-B - D\) GABA transaminase\ **Answer**: C) Monoamine oxidase-B 8. **What is a side effect commonly associated with selegiline?** - A\) Hypertension - B\) Nausea - C\) Peripheral neuropathy - D\) Muscle weakness\ **Answer**: B) Nausea 9. **At high doses, selegiline may lose selectivity and inhibit which enzyme?** - A\) COMT - B\) Monoamine oxidase-A - C\) Dopamine decarboxylase - D\) Acetylcholinesterase\ **Answer**: B) Monoamine oxidase-A **Slide 22 - Rasagiline and Safinamide** 10. **Which MAO-B inhibitor is known for having neuroprotective properties?** - A\) Selegiline - B\) Rasagiline - C\) Safinamide - D\) Entacapone\ **Answer**: B) Rasagiline 11. **Safinamide is a reversible inhibitor of which enzyme?** - A\) COMT - B\) Monoamine oxidase-B - C\) Monoamine oxidase-A - D\) Dopamine decarboxylase\ **Answer**: B) Monoamine oxidase-B 12. **Which drug is more potent: rasagiline or selegiline?** - A\) Selegiline - B\) Rasagiline - C\) Both are equally potent - D\) Neither is potent\ **Answer**: B) Rasagiline **Slide 23 - MAO-B Inhibitors** 1. **Which enzyme do MAO-B inhibitors specifically target?** - A\) Serotonin - B\) Dopamine - C\) Epinephrine - D\) Acetylcholine\ **Answer**: B) Dopamine 2. **Which of the following MAO-B inhibitors is considered more potent and has neuroprotective effects?** - A\) Selegiline - B\) Rasagiline - C\) Tolcapone - D\) Entacapone\ **Answer**: B) Rasagiline 3. **What is a common side effect of MAO-B inhibitors used for Parkinson's disease?** - A\) Hypertension - B\) Hallucinations - C\) Myocardial infarction - D\) Renal failure\ **Answer**: B) Hallucinations **Slide 24 - COMT Inhibitors** 4. **What is the role of COMT inhibitors in Parkinson\'s treatment?** - A\) Increase dopamine synthesis - B\) Prevent peripheral breakdown of levodopa - C\) Stimulate dopamine receptors - D\) Reduce acetylcholine release\ **Answer**: B) Prevent peripheral breakdown of levodopa 5. **Which COMT inhibitor is associated with hepatotoxicity, limiting its use?** - A\) Entacapone - B\) Tolcapone - C\) Selegiline - D\) Rasagiline\ **Answer**: B) Tolcapone 6. **What is a potential harmless side effect of COMT inhibitors like Entacapone?** - A\) Red-colored urine - B\) Headache - C\) Nausea - D\) Bradycardia\ **Answer**: A) Red-colored urine **Slide 25 - Adenosine Antagonists** 7. **What is the mechanism of action for the drug Istradefylline?** - A\) Blocks NMDA receptors - B\) Antagonizes adenosine A2A receptors in the basal ganglia - C\) Inhibits dopamine reuptake - D\) Stimulates serotonin release\ **Answer**: B) Antagonizes adenosine A2A receptors in the basal ganglia 8. **Istradefylline is primarily used as an adjunct treatment for which Parkinson's symptom?** - A\) Bradykinesia - B\) Tremor - C\) \"Off\" episodes - D\) Dyskinesia\ **Answer**: C) \"Off\" episodes 9. **Which enzyme metabolizes Istradefylline, necessitating caution with cytochrome P450 inducers?** - A\) CYP3A4 - B\) CYP2C19 - C\) CYP1A2 - D\) CYP2D6\ **Answer**: A) CYP3A4