Transdermal Delivery Systems PDF

- 1. Define percutaneous absorption 2. What transport process affects drug transport through the skin? What mathematical equation governs this? 3. Identify the following biological and physicochemical factors affecting drug absorption and how they may increase or decre...

- 1. Define percutaneous absorption 2. What transport process affects drug transport through the skin? What mathematical equation governs this? 3. Identify the following biological and physicochemical factors affecting drug absorption and how they may increase or decrease drug absorption. a. Skin hydration b. Drug concentration c. Lipid/aqueous solubility and partition coefficient d. Molecular size and shape of drug e. Surface area f. Contact time 4. What are the advantages of transdermal ointments, creams and gels over transdermal patches? What are the disadvantages? 5. Explain why EvaMist underwent safety review by the FDA 6. What two types of transdermal systems exist? a. What five layers may be included in a transdermal patch? Given an illustration of either patch type, be able to identify these layers. b. How is the manufacturing process different for the two types? 7. Explain what causes activation of the Synera™ lidocaine and tetracaine patch 8. List the advantages and disadvantages of TDDSs 9. TDDS with what type of components should be removed prior to MRI? Why? 10. What are the general clinical considerations in the use of TDDSs (e.g. shouldn\'t be placed at the belt line) 11. What alternative materials are used for *in vitro* percutaneous absorption studies? 12. Define the two types of physical absorption enhancers discussed in class. 13. List the advantages and disadvantages of IP, and what drugs are currently given by this method 14. What drug does IONSYS contain? What is it used for? 15. What is photodynamic therapy? What are its advantages and disadvantages? 16. What are Needle free injections? How are the drug molecules pushed into the skin?