Dementia Drugs Part 3.docx

\#\#\# Slide 14 - Reversible Cholinesterase Inhibitors 1\. \*\*What is the primary mechanism of action of reversible cholinesterase inhibitors in Alzheimer's disease?\*\* \- A) Inhibiting dopamine reuptake \- B) Preventing the breakdown of acetylcholine in the synapse \- C) Enhancing GABA transm...

\#\#\# Slide 14 - Reversible Cholinesterase Inhibitors 1\. \*\*What is the primary mechanism of action of reversible cholinesterase inhibitors in Alzheimer's disease?\*\* \- A) Inhibiting dopamine reuptake \- B) Preventing the breakdown of acetylcholine in the synapse \- C) Enhancing GABA transmission \- D) Blocking NMDA receptors \*\*Answer\*\*: B) Preventing the breakdown of acetylcholine in the synapse 2\. \*\*Which reversible cholinesterase inhibitor was removed from the market due to hepatotoxicity?\*\* \- A) Donepezil \- B) Galantamine \- C) Rivastigmine \- D) Tacrine \*\*Answer\*\*: D) Tacrine 3\. \*\*What benefit does rivastigmine provide in treating Alzheimer's disease?\*\* \- A) Enhances dopamine release \- B) Delays cognitive impairment for at least 6 months \- C) Increases serotonin levels \- D) Reduces NMDA receptor activity \*\*Answer\*\*: B) Delays cognitive impairment for at least 6 months \#\#\# Slide 15 - Efficacy of Cholinesterase Inhibitors 4\. \*\*What is considered a significant change in the ADAS-Cog score when assessing Alzheimer\'s disease?\*\* \- A) A change of 1 point out of 100 \- B) A change of 4 points out of 70 \- C) A change of 10 points out of 50 \- D) A change of 5 points out of 30 \*\*Answer\*\*: B) A change of 4 points out of 70 5\. \*\*How do cholinesterase inhibitors affect the MMSE (Mini-Mental State Exam) score?\*\* \- A) Improve MMSE by 3 points \- B) Improve MMSE by 1 point \- C) Decrease MMSE by 2 points \- D) Have no impact on MMSE score \*\*Answer\*\*: B) Improve MMSE by 1 point 6\. \*\*What test is used to evaluate cognitive areas such as attention, orientation, and language in moderate to severe dementia?\*\* \- A) ADAS-Cog \- B) CIBIC \- C) MMSE \- D) SIB \*\*Answer\*\*: D) SIB \#\#\# Slide 16 - Cholinesterase Inhibitors and Side Effects 7\. \*\*What is a significant side effect associated with cholinesterase inhibitors?\*\* \- A) Tachycardia \- B) Bradycardia \- C) Hypertension \- D) Weight gain \*\*Answer\*\*: B) Bradycardia 8\. \*\*Which class of drugs can inhibit the beneficial effects of cholinesterase inhibitors in Alzheimer's patients?\*\* \- A) Dopamine agonists \- B) Anticholinergic drugs \- C) SSRIs \- D) MAO inhibitors \*\*Answer\*\*: B) Anticholinergic drugs 9\. \*\*Cholinesterase inhibitors can interact with which cytochrome P450 enzyme system?\*\* \- A) CYP3A4 \- B) CYP2D6 \- C) CYP1A2 \- D) CYP2C9 \*\*Answer\*\*: A) CYP3A4 \#\#\# Slide 17 - NMDA Blockers 10\. \*\*Memantine, used in Alzheimer's treatment, works by blocking which receptor?\*\* \- A) Dopamine \- B) NMDA \- C) Serotonin \- D) Acetylcholine \*\*Answer\*\*: B) NMDA 11\. \*\*Memantine is most beneficial in which stage of Alzheimer's disease?\*\* \- A) Early-stage \- B) Asymptomatic \- C) Moderate to severe \- D) Preclinical \*\*Answer\*\*: C) Moderate to severe 12\. \*\*What is a common side effect of NMDA blockers like memantine?\*\* \- A) Weight gain \- B) Dizziness \- C) Increased appetite \- D) Hyperactivity \*\*Answer\*\*: B) Dizziness \#\#\# Slide 18 - Clinical Tips 13\. \*\*In which situation should Alzheimer's medications be tapered off?\*\* \- A) Patient shows rapid improvement in cognitive function \- B) End of life care or side effects \- C) At the beginning of treatment \- D) When the patient has trouble swallowing food \*\*Answer\*\*: B) End of life care or side effects 14\. \*\*What is a reason to stop Alzheimer's medication in a patient?\*\* \- A) Significant improvement within 3 months \- B) Severe side effects or MMSE \< 10 \- C) Elevated serum creatinine levels \- D) Lack of side effects \*\*Answer\*\*: B) Severe side effects or MMSE \< 10 15\. \*\*If Alzheimer's medications show no desired effects after how many months should they be tapered off?\*\* \- A) 1 month \- B) 6 months \- C) 3 to 6 months \- D) 12 months \*\*Answer\*\*: C) 3 to 6 months