crhons-vs-ulcerative-colitis.pdf

Inflammatory bowel disease By Dr. Haitham Nabeel Your Date Here Your Footer Here  Crohn disease Vs Ulcerative colitis Your Date Here Your Footer Here Epidemiology Crohn disease...

Inflammatory bowel disease By Dr. Haitham Nabeel Your Date Here Your Footer Here  Crohn disease Vs Ulcerative colitis Your Date Here Your Footer Here Epidemiology Crohn disease Ulcerative colitis Less common More common Increasing incidence Stable incidence Slightly more common in females M=F From childhood onwards From puberty onwards Your Date Here Your Footer Here 3 Etiology Crohn disease Ulcerative colitis Stronger role of genetics than UC Weaker genetic role than CD Associated with NOD2 mutation NOD2 mutation is rare Smoking increases the risk More common in non-/ex-smokers Appendicectomy protects Your Date Here Your Footer Here 4 Sites of distribution Crohn disease Ulcerative colitis Your Date Here Your Footer Here 5 Symptoms Crohn disease Ulcerative colitis Watery nonbloody diarrhea Bloody diarrhea with mucus Slight increase in stool frequency Marked increase in stool frequency Right lower quadrant pain Left lower quadrant pain Constitutional symptoms are common Constitutional symptoms are non common Your Date Here Your Footer Here 6 Diagnostics Endoscopy Crohn disease Ulcerative colitis Discontinuous Continuous Linear ulcers Reddened mucosa Cobblestone appearance Bleeding on contact Strictures Superficial ulcers Your Date Here Your Footer Here 7 Diagnostics Endoscopy Crohn disease Ulcerative colitis Your Date Here Your Footer Here 8 Diagnostics histology Crohn disease Ulcerative colitis Patchy inflammation Continuous inflammation All layers of bowel wall affected Limited to mucosa Deep ulcers Superficial ulcers Non-caseating granuloma Crypt abscesses Your Date Here Your Footer Here 9 Diagnostics histology Crohn disease Ulcerative colitis Your Date Here Your Footer Here 10 Diagnostics Imaging Crohn disease Ulcerative colitis Stricture (string sign) Loss of colonic haustra (Lead pipe sign) Abscesses Fistulas Your Date Here Your Footer Here 11 Diagnostics Imaging Crohn disease Ulcerative colitis Your Date Here Your Footer Here 12 Complications Crohn disease Ulcerative colitis Fistulas, stricture & abscesses are more common Fistulas, stricture & abscesses are more common Lower risk of colorectal cancer Higher risk of colorectal cancer Skin, joint and eye complications are more common Hepatic complication are more common Your Date Here Your Footer Here 13 Management Crohn disease Ulcerative colitis Steroids for acute attack 5-ASA for acute attacks and steroids if no response to 5-ASA Thiopurines for maintenance 5-ASA for maintenance Surgery is non-curative Surgery is curative Your Date Here Your Footer Here 14 THANK YOU! Do you have any questions?