Copy of Heme-Lymph E2 Myeloid Neoplasms - Kathryn Thomas (2017).pdf

Type Epidemiology Cell Type Genetics or Mutations Histology Misc. Images Acute Myeloid Leukemia Adults...

Type Epidemiology Cell Type Genetics or Mutations Histology Misc. Images Acute Myeloid Leukemia Adults Myeloid precursors in t(8;21)(q22;q22) - RUNX1-RUNX1T1; Accumulation of myeloblasts or immature AML with t(8;21)(q22;q22) Children RUNX1-RUNX1T1 Large blasts, Auer rods, granules Poor prognostic factors: High initial WBC, AML with inv(16)(p13.1;q22) Adults Fusion of CBFB with MYH11 Myeloblasts, monoblasts, eosinophil precursors KIT mutation Acute Promyelocytic with Retinoic acid receptor-alpha - antagonzing Abnormal promyelocytes; Auer bodies ("faggot Decreased WBC, disseminated intravascular Adults t(15;17)(q22;a12), M3 differentiation cells") coagulation (DIC) Dimorphic RBCs, ringed sideroblasts, nuclear Sx related to cytopenias or defective platelet Myelodysplastic Syndromes budding, pseudo Pelger-Huet cells, toxic aggregation;