Copy of Heme-Lymph E2 Myeloid Neoplasms PDF
Document Details
2017
Kathryn Thomas
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Summary
This document discusses various types of myeloid neoplasms, including acute myeloid leukemia (AML), acute promyelocytic leukemia (APL), and myelodysplastic syndromes (MDS). It covers epidemiology, cell types, genetics and mutations, histology, and miscellaneous aspects of each type. The document provides a detailed overview of different myeloid neoplasms, their characteristics, and potential prognostic factors.
Full Transcript
Type Epidemiology Cell Type Genetics or Mutations Histology Misc. Images Acute Myeloid Leukemia Adults...
Type Epidemiology Cell Type Genetics or Mutations Histology Misc. Images Acute Myeloid Leukemia Adults Myeloid precursors in t(8;21)(q22;q22) - RUNX1-RUNX1T1; Accumulation of myeloblasts or immature AML with t(8;21)(q22;q22) Children RUNX1-RUNX1T1 Large blasts, Auer rods, granules Poor prognostic factors: High initial WBC, AML with inv(16)(p13.1;q22) Adults Fusion of CBFB with MYH11 Myeloblasts, monoblasts, eosinophil precursors KIT mutation Acute Promyelocytic with Retinoic acid receptor-alpha - antagonzing Abnormal promyelocytes; Auer bodies ("faggot Decreased WBC, disseminated intravascular Adults t(15;17)(q22;a12), M3 differentiation cells") coagulation (DIC) Dimorphic RBCs, ringed sideroblasts, nuclear Sx related to cytopenias or defective platelet Myelodysplastic Syndromes budding, pseudo Pelger-Huet cells, toxic aggregation;
