Copy of Heme-Lymph E2 Lymphoid and Myeloid Neoplasms - Kathryn Thomas (2017) - Google Sheets.pdf

Type Epidemiology Cell Type Cell Markers Genetics or Mutations Histology Misc. Image...

Type Epidemiology Cell Type Cell Markers Genetics or Mutations Histology Misc. Image ETV6-RUN1 (TEL-AML1) - B-Cell Acute Lymphoblastic self-renewal; MLL-AFF1 (AF4) - Blast-like cells; frequent mitotic figures; "Starry Children Immature B Cells CD19, CD22, CD79a, PAX5 Pancytopenia, stormy onset of sx Leukemia/Lymphoblastic Lymphoma block hematopoietic cell sky" appearance differentiation and reduce cell death T-Cell Acute Lymphoblastic Teens and young men Immature T cells CD2, CD3, CD5, CD7 NOTCH1 - transcriptional activator Chornic Lymphocytic Leukemia/Small Adults B cells CD5, CD23; NEGATIVE FOR Deletions of 13q14.3 Small, clonal mature lymphocytes with "soccer ball" Progressive accumulation of incompetent MLL2; t(14;18)(q32;q21), Most common form of non-Hodgkin Follicles without normal architecture, arranged in Follicular Lymphoma Adults Germinal/follicular B cells CD10, Bcl2 in follicles overexpression of Bcl2 and prevents lymphoma in US; marrow involvement, nodules apoptosis anemia t(11;14)(q13;q32) - overexpression of CD5, CD20, cyclin D1; Resemble cells of mantle zone of lymph nodes; Mantle Cell Lymphoma Adults B cells cyclin D1, accelerated passage NEGATIVE FOR CD23 monotonous small lymphocytes through G1 Three types: MALT (most common, CD19, CD20, CD79a; secondary to persistent antigenic stimulation), Marginal Zone Lymphoma B memory cells NEGATIVE for CD5, CD10, API2-MALT1; activation of NF-kB Lymphoepithelial lesions, follicular pattern Nodal, Splenic; Stomach most common CD23 extranodal site, associated with H. pylori B Cell markers (CD19, CD20, BRAF - serine/threonine protein Tumor cells containing hair-like projections; CD79a, PAX5); CD11c, CD103; Circumferential threadlike extensions or round or Hairy Cell Leukemia Middle-aged men kinase, affects cell division, Massive splenomegaly with obliteration of NEGATIVE FOR CD5, CD10, indented nuclei differentiation, secretion white pulp; pancytopenia CD23 Bcl6 - transcription factor that represses transcription of target genes, promotes B-cell proliferation, Most common Non-Hodgkin lymphoma; Diffuse Large B Cell Lymphoma Adults B cells CD19, CD20, CD79a, Bcl6 Diffuse growth pattern with large cells hypermutation without inducing a heterogeneous p53/TP53-dependent apoptotic response; t(14;18)(Bcl2) Associated with HHV8 and HIV; no tumor Primary Effusion Lymphoma mass Burkitt's Leukemia - tumor cells in blood and diffuse marrow involvement; B cell Lymphoma with features intermediate Monomorphic cells with round nuclei; "starry sky" Burkitt Lymphoma Children and Adults B cells CD10, Ki-67 c-myc between Burkitt Lymphom and diffuse large appearance B-cell lymphoma - translocations involving c-myc and Bcl2 or Bcl6; Associated with HIV+ Fibrillary protein, non-branching fibrils in a Pale pink amorphous material; apple-green Amyloidosis beta-pleated sheet; detected with birefringence with Congo Red stain immunofixation Multiple Myeloma Middle-aged to elderly Less differentiated than plasma CD38, CD138; NEGATIVE FOR IgH translocation - t(4;14)(p16;q32), Perinuclear clearing, Mott cells, Russell bodies, Expresses antigens associated with Solitary Myeloma (Plasmacytoma) Plasma cell Similar to multiple myeloma Forms discrete mass Monoclonal Gammopathy of Older African Americans Monoclonal Ig in serum or urine without MYD88 - pyogenic bacterial Small B cells with plasmacytic differentiation; NO Waldenstrom macroglobulinemia with Lymphoplasmacytic Lymphoma B cells CD19, CD20, CD128 infections and Waldenstrom evidence of other B cell lymphoma; Russell bodies hyperviscosity symptoms; autoimmune macroglobulinemia and Dutcher bodies hemolysis Peripheral T-Cell and NK-Cell Most common Far East T cells and NK cells CD3,CD5, CD7 Associated with EBV or HTLV-1 Anaplastic Large-Cell Lymphoma `ALK (mutation also in inflammatory Younger men T cells and NK cells ALK, CD30, CD45 Horseshoe nuclei, "doughnut" ells (ALK Positive) myofibroblastic tumor CD3, CD4; NEGATIVE FOR Adult T-Cell Leukemia/Lymphoma Adult men T cells and NK cells Viral protein Tax activates NF-kB Cloverleaf/flower cells Caused by HTLV-1; hypercalcemia, infections CD30, ALK Associated with Rheumatoid Arthritis; Large Granular Lymphocytic Elderly T cells and NK cells CD3 if T cell, CD56 if NK cell STAT3 Large lymphocytes with azurophilic granules neutropenia, aplastic anemia, Leukemia thrombocytopenia Vascular damage and destruction, necrosis, Nasal Extranodal NK/T Cell cytotoic, associated with EBV; most common Asians and Native Americans T cells and NK cells Lymphoma location in upper aerodigestive tract; highly aggressive Hodgkin Reed-Sternberg cells - large will with Bimodal - age 15-35 and late life CD30, CD15; NEGATIVE FOR Classical Hodgkin Lymphoma Mostly B cells Self-activation of NF-kB bilobed nucleus, owl-eyed eosinophilic nucleioli; Assocaited with EBV (>54) CD45 background inflammatory cells Nodular Sclerosis Classical Hodgkin Only subtype without male CD30, CD15; NEGATIVE FOR Nodule growth pattern with broad collagen bands, Mostly B cells Most common Lymphoma predominant CD45 RS cells; Lacunar cells Mixed Cellularity Classical Hodgkin Developing countries without CD30, CD15; NEGATIVE FOR Scattered RS cells in inflammatory background Mostly B cells Associated with HIV Lymphoma bimodal distribution CD45 without sclerosing fibrosis Lymphocyte-Rich Classical Hodgkin CD30, CD15; NEGATIVE FOR Scattered RS cells in nodular without neutrophils Mostly B cells Lymphoma CD45 or eosinophils Lymphocyte-Depleted Classical CD30, CD15; NEGATIVE FOR Rich in RS cells or depleted in non-neoplastic Mostly B cells Hodgkin Lymphoma CD45 lymphocytes Nodular Lymphocyte-Predominant CD45, CD20; NEGATIVE FOR LP tumor cells (popcorn cells); Background Bimodal - children and age 30-40 Follicular B cells Hodgkin Lymphoma CD15, CD30 lymphocytes - B cells > T cells