Common Drug Toxicities PDF

Common drug toxicities. Toxicity Drug Agranulocytosis Clozapine Chloramphenicol C Aplastic Anemia NSAIDs N Benzene...

Common drug toxicities. Toxicity Drug Agranulocytosis Clozapine Chloramphenicol C Aplastic Anemia NSAIDs N Benzene B Atropine-like Side Effects Tricyclics Doxorubicin Cardiotoxicity rubicin Daunorubicin - Cartilage Damage in - Fluoroquinolones (Ciprofloxacin & Norfloxacin) children Cinchonism Quinidine Cough ACE Inhibitors Diabetes Insipidus Lithium Metronidazole Oo Disulfiram-like effect Sulfonylureas (1st generation) M Extrapyramidal Side Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine) Effects Fanconi's Syndrome Tetracycline Valproic Acid V Fatal Hepatotoxicity Halothane H (necrosis) Acetaminophen A Gingical Hyperplasia Phenytoin Gray Baby Syndrome Chloramphenicol a Cimetidine Azoles Spironolactone Gynecomastia Digitalis i Hemolytic Anemia in Sulfonamides G6PD-deficiency Isoniazid Aspirin AMMDacanayRPh©2020 Saint Louis University – Department of Pharmacy  Ibuprofen Primaquine Hepatitis Isoniazid Niacin Tamoxifen Hot Flashes, Flushing Ca++ Channel Blockers Barbiturates Phenytoin Induce CP450 Carbamazepine Rifampin Cimetidine Inhibit CP450 Ketoconazole Methicillin NSAIDs (except Aspirin) Interstitial Nephritis Furosemide Sulfonamides Nitroglycerin Industrial exposure ----> tolerance during week ----> loss of tolerance during Monday Disease weekend ----> headache, tach, dizziness upon re-exposure Orange Body Fluids Rifampin Heparin Osteoporosis Corticosteroids Positive Coombs' Test Methyldopa Bleomycin Pulmonary Fibrosis Amiodarone Red Man Syndrome Vancomycin Severe HTN with MAOIs Tyramine Procainamide SLE-like Syndrome Hydralazine Tardive Dyskinesia Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine) Aspirin Tinnitus Quinidine AMMDacanayRPh©2020 Saint Louis University – Department of Pharmacy